Abstract：
:We examined the distribution of drugs in a 49-year-old brain-dead man. Our objective was to determine the possibility of diagnosing how and at what point the patient became brain dead. The presence of mepivacaine, pentazocine, lidocaine and thiamylal in various tissues, including seven regions of the brain were confirmed, using gas chromatography/mass spectrometry. Tissue-to-blood concentration ratios of mepivacaine, pentazocine and lidocaine in the brain were higher than these ratios in other tissues, while ratios of thiamylal were lower. Therefore, cerebral blood flow was likely to have ceased between the administration of the former drugs and that of the latter drug, in agreement with clinical records. Among seven regions of the brain, the ratios of the former three drugs were high in occipital and parietal lobes, and were low in the cerebellum and medulla oblongata. On the other hand, the ratios of the latter drug were high in the cerebellum and the medulla oblongata. Therefore, cerebral blood flow presumably ceased first in occipital and parietal lobes, and last in the cerebellum and the medulla oblongata. Based on these results, assessment of concentrations of drugs in human tissues, including various regions of brain is useful to determine the time and progression of brain death.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Jitsufuchi N,Kudo K,Imamura T,Kimura K,Ikeda Ndoi
10.1016/s0379-0738(97)00155-2subject
Has Abstractpub_date
1997-11-10 00:00:00pages
103-9issue
1-2eissn
0379-0738issn
1872-6283pii
S0379-0738(97)00155-2journal_volume
90pub_type
杂志文章abstract：:Seventeen Y-chromosomal short tandem repeats (STRs), DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, GATA-H4, DYS448, DYS456, DYS458, DYS635 were typed in DNA samples from the Kalmyk population (n=99). The population is characterized by a high proportion of duplicated DYS19 ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.11.013
更新日期：2007-12-20 00:00:00
abstract：:The interpretation of vehicle paint traces in forensic casework hinges on a number of factors including the type of paint, colour, number of layers, and background information. Vehicle colour surveys are an important source of information for the forensic paint examiner when interpreting the level of significance of a...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.12.010
更新日期：2015-03-01 00:00:00
abstract：:Population genetic data for the 15 STRs included in the AmpFlSTR Identifiler kit were obtained from a sample of 168 unrelated individuals of the ethnic group of Polish Tatars residing in the Northeastern Poland. Significant differences revealed in relation to the autochthonous Poles by using R x C test as well as F(ST...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.07.009
更新日期：2005-05-10 00:00:00
abstract：:Frontal sinuses of Japanese skulls were radiographically examined from the view point of identifying individuals. The system of classification of sinus was proposed, basing on the area size, the bilateral asymmetry, the superiority of side, the outline of upper borders, the partial septa and the supraorbital cells. Fr...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(87)90041-7
更新日期：1987-08-01 00:00:00
abstract：:Pubic hair is often analyzed as an alternative to scalp hair to prove previous drug use. However, urine is a potential source of external contamination. In the present study, the concentrations of methamphetamine (MA) and amphetamine (AP) in both scalp and pubic hair from illegal MA users were compared. Furthermore, i...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.06.009
更新日期：2011-03-20 00:00:00
abstract：:Foreign body aspiration is frequently encountered in young children, in the majority of cases it will not lead to an adverse outcome. However, in case of coin battery ingestion more serious adverse outcomes, including death, have been reported. We present a case with fatal outcome due to exsanguination, of a 2-year-ol...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.02.001
更新日期：2010-05-20 00:00:00
abstract：:The present study was made on an experimental animal model of a death from anaphylaxis, in which postmortem changes in levels of histamine and 1-methylhistamine, in whole blood were measured. Instead of the usual immunological method administering compound 48/80, a degranulating agent of mast cell and the effect close...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90233-o
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:Internationally, urine on-site testing has been used for detecting drivers under the influence of drugs (DUID) but more and more countries, such as Belgium, are switching to oral fluid screening. OBJECTIVE:To compare the previous (published in 1999) and current (published 2009) enforcement procedures of DUI...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.01.034
更新日期：2015-04-01 00:00:00
abstract：:The importance of temperature data in minimum postmortem interval (minPMI) estimations in criminal investigations is well known. To maximise the accuracy of minPMI estimations, it is imperative to investigate the different components involved in temperature modelling, such as the duration of temperature data logger pl...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.110028
更新日期：2020-01-01 00:00:00
abstract：:In cases of disputed parentage the biostatistical information is contained in the frequencies X and Y (as defined by Essen-M oller ); X denotes the hypothesis "paternity", Y the hypothesis "non-paternity". Essen-M oller proposed a probability of paternity which includes both values: W = X/(X + Y) (where X + Y becomes ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(84)90010-0
更新日期：1984-05-01 00:00:00
abstract：:Driving while intoxicated (DWI) legislation requires proving the critical breath alcohol concentration (BrAC) at the time of driving. With time delayed analysis, retrograde extrapolation is occasionally employed but has several uncertainties associated with it. The present study attempts to address whether subjects ac...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(92)90013-m
更新日期：1992-12-01 00:00:00
abstract：:In cases of criminal thallium poisoning, forensic investigation is required to identify the amount and time of thallium exposure. Usually, blood and urine thallium levels are respectively used as biomarkers. Additionally, hair has the unique potential to reveal retrospective information. Although several studies have ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2018.08.019
更新日期：2018-10-01 00:00:00
abstract：:The growth of five variables of the tibia (diaphyseal length, diaphyseal length plus distal epiphysis, condylo-malleolar length, sagittal diameter of the proximal epiphysis, maximum breadth of the distal epiphysis) were analysed using polynomial regression in order to evaluate their significance and capacity for age a...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.07.038
更新日期：2012-01-10 00:00:00
abstract：:We have identified a new compound in capsules marketed as plant feeders available from internet suppliers. It is apparent from internet forums that these so-called plant feeders are being used as recreational drugs. The material is identified as being 3'-fluoromethcathinone. The compound in the capsule was identified ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.11.013
更新日期：2009-03-10 00:00:00
abstract：:The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensa...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.03.034
更新日期：2016-06-01 00:00:00
abstract：:The aim of this study was to characterize the concentrations of total and specific IgE as well as mast cell-derived tryptase in postmortem serum from femoral blood and evaluate the usefulness of their determination for diagnostic purposes in cases of fatal asthma attacks. 36 autopsy cases were retrospectively selected...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.11.001
更新日期：2016-12-01 00:00:00
abstract：:Urine morphine levels after the consumption of poppy seeds were measured in two separate trials. Maximum levels of approximately 18 micrograms/ml were found using RIA, EMIT-ST and GC methodologies. Positive immunoassay results were seen up to 60 h post-ingestion. Several different lots of seeds from various sources we...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(85)90173-2
更新日期：1985-02-01 00:00:00
abstract：:Histological findings of the temporal bone in 23 autopsy cases of various asphyxial fatalities were studied. The temporal bones of 12 cases who died of tumors including mammary cancer, gastric cancer, myxoma of heart and craniopharyngioma, the bones of 3 cases of heart attack and the bones of 17 cases who died of vari...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90243-r
更新日期：1990-02-01 00:00:00
abstract：:Organised criminality is a great concern for national/international security. The demonstration of complex crimes is increasingly dependant on knowledge distributed within law-enforcement agencies and scientific disciplines. This separation of knowledge creates difficulties in reconstructing and prosecuting such crime...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.06.032
更新日期：2007-04-11 00:00:00
abstract：:The survival of the tiger (Panthera tigris) is seriously threatened by poaching to provide raw materials for traditional Chinese medicines (TCMs). Most highly prized are the tiger's bones, which are used in combination with other animal and plant derivatives in pills and plasters for the treatment of rheumatism and ot...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(02)00045-2
更新日期：2002-04-18 00:00:00
abstract：:Identification in forensic anthropology and the definition of a biological profile in bioarchaeology are essential to each of those fields and use the same methodologies. Sex, age, stature and ancestry can be conclusive or dispensable, depending on the field. The Fordisc(®) 3.0 computer program was developed to aid in...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.03.011
更新日期：2011-05-20 00:00:00
abstract：:An accurate and precise estimate of stature can be very useful in the analysis of human remains in forensic cases. A problem with many stature estimation methods is that an unknown individual must first be assigned to a specific group before a method can be applied. Group membership has been defined by sex, age, year ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.12.011
更新日期：2016-02-01 00:00:00
abstract：:An extensive literature review and new post-irradiation experimental results are presented of genotyping blood stains and hair, and physical examinations of latent fingerprints, hairs, and fibers. Results indicate that successful development of nuclear short tandem repeat (STR) and mitochondrial DNA sequence profiles ...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2018.01.012
更新日期：2018-03-01 00:00:00
abstract：:Forensic assessment of skeletal material includes age estimation of unknown individuals. When dealing with extremely fragmented human remains that lack macro-features used in age estimation, histological assessment of the skeletal elements can be employed. Historically, microscopic methods for age assessment used by f...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110335
更新日期：2020-08-01 00:00:00
abstract：:One hundred and seventy nine cases of acute poisoning constituting 1.1% of all admissions to the medical unit over 3 years were analysed. Eighty-three per cent of the patients were under 30 years of age and 72% were males. The common agents were: OP insecticides in 51%, kerosene oil in 12%, rat poison in 8% and drugs ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(88)90221-6
更新日期：1988-01-01 00:00:00
abstract：:Several studies have shown variability in osteometric measurements of the skull between populations. Therefore, each population should have specific standards to optimize the accuracy of identification. The aim of this study was to evaluate the sexual dimorphism in metric relations between anatomical points of the sku...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.109916
更新日期：2019-09-01 00:00:00
abstract：:The mass spectrum of the drug of abuse 2,5-dimethoxyamphetamine (2,5-DMA) is characterized by an imine fragment base peak at m/z 44 and additional fragments at m/z 151/152 for the dimethoxybenzyl cation and radical cation, respectively. Five positional ring isomers of dimethoxyamphetamines (DMA) have an isomeric relat...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.08.010
更新日期：2009-11-20 00:00:00
abstract：:A previously identified difficulty with the development of latent fingerprints on low-density polyethylene (LDPE) by vacuum metal deposition (VMD) is that excess gold deposition prevents effective zinc deposition and so inhibits latent print development [1]. The investigation of a means to correct for excess gold depo...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(01)00507-2
更新日期：2001-11-15 00:00:00
abstract：:A team of Finnish forensic experts performed investigations of alleged mass graves in Kosovo under the mandate of the European Union (EU). Human skeletal remains from two locations were examined. The remains contained three almost complete skeletons, and individual bones and bone fragments, part of which were burned. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(01)00395-4
更新日期：2001-10-01 00:00:00
abstract：:In rabbits, intracerebrally applied erythrocytes can move with the cerebrospinal fluid along connecting pathways between the subarachnoid space and the cervical lymph nodes. This study compares the time dependency for the degradation of intracerebrally injected erythrocytes in the brain as well as in the cervical lymp...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(83)90089-0
更新日期：1983-01-01 00:00:00
