Relationship of natural incidence and radiosensitivity for bone cancer in dogs.

Abstract:

:A comparison of the risk coefficients for 239Pu- or 226Ra-induced bone cancer in two canine breeds, one with a relatively low (beagle) and the other with a very high (St. Bernard) natural incidence, indicated only slightly higher risk in the giant breed. The differences in risk for skeletal malignancy in 239Pu and 226Ra dogs were nonsignificant (p > 0.05). Likewise, the values of the 239Pu:226Ra "toxicity ratios" for these respective breeds, using bone cancer as the endpoint, were not significantly different at the 0.05 level. The anatomical distribution of the radiation-induced bone tumors tended to be a function of both the bone mass and the skeletal distribution of the radionuclide, not the site of predilection for naturally occurring bone neoplasia. Although the etiology of the higher natural incidence of bone cancer in the St. Bernard was not determined, several possible factors, including a higher osteoblastic activity level in the St. Bernards, are presented. These data suggest that making extrapolations of radiation-induced bone cancer risk from animals to humans is valid.

journal_name

Health Phys

journal_title

Health physics

authors

Taylor GN,Lloyd RD,Mays CW,Miller SC,Jee WS,Mori S,Shabestari L,Li XJ

doi

10.1097/00004032-199710000-00014

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

679-83

issue

4

eissn

0017-9078

issn

1538-5159

journal_volume

73

pub_type

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