Abstract:
PURPOSE:We have devised, implemented, and tested a technique for creating a comprehensive probabilistic atlas of the human cerebral cortex, based on high-dimensional fluid transformations. The goal of the atlas is to detect and quantify subtle and distributed patterns of deviation from normal cortical anatomy, in a 3D brain image from any given subject. METHOD:Given a 3D MR image of a new subject, a high-resolution surface representation of the cerebral cortex is automatically extracted. The algorithm then calculates a set of high-dimensional volumetric maps, fluidly deforming this surface into structural correspondence with other cortical surfaces, selected one by one from an anatomic image database. The family of volumetric warps so constructed encodes statistical properties of local anatomical variation across the cortical surface. Additional strategies are developed to fluidly deform the sulcal patterns of different subjects into structural correspondence. A probability space of random transformations, based on the theory of anisotropic Gaussian random fields, is then used to encode information on complex variations in gyral and sulcal topography from one individual to another. A complete system of 256(2) probability density functions is computed to reflect the observed variability in stereotaxic space of the points whose correspondences are found by the warping algorithm. Confidence limits in stereotaxic space are determined for cortical surface points in the new subject's brain. RESULTS:Color-coded probability maps are generated, which highlight and quantify regional patterns of deformity in the anatomy of new subjects. These maps indicate locally the probability of each anatomic point being as unusually situated, given the distributions of corresponding points in the scans of normal subjects. 3D MRI volumes are analyzed, from subjects with clinically determined Alzheimer disease and age-matched normal subjects. CONCLUSION:Applications of the random fluid-based probabilistic atlas include the transfer of multisubject 3D functional, vascular, and histologic maps onto a single anatomic template, the mapping of 3D atlases onto the scans of new subjects, and the rapid detection, quantification, and mapping of local shape changes in 3D medical images in disease and during normal or abnormal growth and development.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Thompson PM,MacDonald D,Mega MS,Holmes CJ,Evans AC,Toga AWdoi
10.1097/00004728-199707000-00008subject
Has Abstractpub_date
1997-07-01 00:00:00pages
567-81issue
4eissn
0363-8715issn
1532-3145journal_volume
21pub_type
杂志文章abstract:OBJECTIVE:We describe a manual segmentation and image fusion method to assess the relationship between liver tumors and the radiofrequency ablation zone depicted on cross-sectional imaging. CONCLUSIONS:Manual fusion of segmented images of hepatic tumors from a preprocedural scan with the ablation zone depicted on the ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181c4f797
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:The Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Trial phase III is a multicenter, randomized clinical trial in the management and treatment of subjects with small intracerebral hemorrhage and large intraventricular hemorrhage. Accurate localization, segmentation, and quantific...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/RCT.0b013e318245c1fa
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to explore the response to neoadjuvant chemotherapy (NAC) in nonconcentric shrinkage pattern of breast cancer (BC) patients using H-magnetic resonance spectroscopy. METHODS:Twenty-five BC patients were the study cohort. All patients received AT-based regimen as first-line treatment....
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000647
更新日期:2018-01-01 00:00:00
abstract::We evaluated the feasibility of angiographic computed tomography (ACT) for diagnostic imaging in a patient with degenerative lumbar spine disease. ACT provides a volume data set out of a rotational acquisition with a c-arm-mounted flat-panel detector. Using this technique, radiographic myelography and myelographic com...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000228152.73528.54
更新日期:2006-09-01 00:00:00
abstract::Urachal carcinoma arises in the clinically silent extraperitoneal space between the bladder apex and the umbilicus. Computed tomography was used to correctly diagnose and stage urachal cancer in two patients. In one case a mass was localized to the bladder wall and immediate juxtavesical region; in the other case an a...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-198811000-00014
更新日期:1988-11-01 00:00:00
abstract::Aeration of the middle turbinate, termed "concha bullosa," is a common anatomical variant of intranasal anatomy. Of 320 patients evaluated for sinus disease with coronal CT, 34% had concha bullosa on at least one side. The overall incidence of inflammatory disease in the ostiomeatal complex in these symptomatic patien...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198809010-00012
更新日期:1988-09-01 00:00:00
abstract:PURPOSE:The goals of this work were to evaluate the practical utility of MRI to quantify myocardial mass in patients with hypertrophic cardiomyopathy (HCM), define the differences in myocardial mass measurements obtained with three-dimensional and geometric MR methods in patients with normal left ventricular morphology...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199907000-00018
更新日期:1999-07-01 00:00:00
abstract::The inhalation of small quantities of carbon-11 labeled carbon monoxide results in a useful red cell label to identify vascular structures in the body and quantitate red cell concentration in tissues. Transverse section images are obtained using PC-II, the Massachusetts General Hospital (MGH) Positron Camera. Attenuat...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-197811000-00001
更新日期:1978-11-01 00:00:00
abstract:PURPOSE:Recently, a new specific organ dose adaption and reduction protocol, or SODAR tool (X-CARE, Siemens Healthcare), which reduces dose to the anterior aspect of the body of patients, was installed on our computed tomographic scanner. The purpose of this pilot project was to evaluate image quality and dose distribu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318251ec61
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To describe the thin-section computed tomography (CT) findings of Sjogren syndrome accompanying pulmonary amyloidosis and lymphoproliferative disease and to compare these with histopathologic findings. SUBJECTS AND METHODS:The thin-section CT findings of 5 women (age range: 42-59 years, mean age=50 years) wi...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200411000-00008
更新日期:2004-11-01 00:00:00
abstract::A new technique is described that utilises a novel magnetic resonance pulse sequence to produce a quantitative index both for ventricular and, for the first time, extraventricular intracranial CSF volumes. The pulse sequence is a combination of a null-point inversion recovery sequence with an extended spin-echo read (...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198609000-00015
更新日期:1986-09-01 00:00:00
abstract::Thirty patients with suspected or known chronic aortic dissection were imaged with magnetic resonance (MR), CT, and angiography. Five of these patients had previously undergone surgical repair of the ascending aorta for a type A dissection. Magnetic resonance demonstrated an intimal flap and a double lumen in 25 cases...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198711000-00009
更新日期:1987-11-01 00:00:00
abstract::Primary cardiac lymphomas, defined as those involving only the heart and pericardium, are extremely rare tumors. These tumors are commonly fatal and until recently were rarely diagnosed antemortem. We describe the CT and MR findings in a case of primary lymphoma of the heart currently responding to chemotherapy. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199311000-00025
更新日期:1993-11-01 00:00:00
abstract::To evaluate the ability of gradient echo MR to define the vacuum phenomena, 14 cadaveric lumbar spines were imaged by spin echo and gradient echo MR, CT, and plain radiography following injection of varying amounts of air into the intervertebral disks. Gradient echo MR was more sensitive than spin echo MR or plain rad...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199103000-00008
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) on T2-weighted magnetic resonance imaging of liver parenchyma. METHODS:Forty-six patients with suspected hepatic tumors (group 1) underwent breath-hold T2-weighted fast spin echo imaging before and after 4 minu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181bc961b
更新日期:2010-03-01 00:00:00
abstract::Perineural spread along the nasociliary branch of the ophthalmic nerve has not been previously described, to our knowledge. One case of cutaneous squamous carcinoma at the medial canthus and another of melanoma of the nasal ala, with nasociliary nerve perineural spread, are illustrated here. Whereas magnetic resonance...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31827cd39e
更新日期:2013-03-01 00:00:00
abstract::The objective of this study was to assess the efficacy of MR mammography (MRM) in evaluating breast cancer extent in women with fatty or dense breasts, and its contribution to the therapeutic approach. The authors reviewed 97 carcinomas detected in 93 women (both symptomatic and from screening) that were classified in...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000191684.51215.9c
更新日期:2006-01-01 00:00:00
abstract::MR imaging is useful in differentiating and characterizing renal masses. A careful evaluation of the signal characteristics and morphology of a renal mass combined with the ancillary imaging findings and patient history should assist the radiologist in making the proper diagnosis or recommending the appropriate treatm...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/01.rct.0000135278.89314.60
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:Advances in computed tomography technology may permit the evaluation of coronary disease, aortic dissection, and pulmonary embolism with a single contrast bolus and breath hold. We sought to determine whether 64-slice computed tomography angiography (CTA) allows for simultaneous visualization of the coronary...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31817c12b1
更新日期:2009-03-01 00:00:00
abstract::Twenty-five patients with surgically and histologically proven squamous cell carcinoma of the palatine tonsil were studied with computed tomography (CT) using a high dose intravenous contrast enhancement technique. With this technique, CT demonstrated the primary carcinoma within the palatine fossa as well as its cont...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198312000-00007
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:Sequential computed tomography (CT) technique remains the most common protocol for CT evaluation of the head despite nearly universal adoption of continuous technique for all other body parts. This may be attributable to the belief by radiologists that this technique is superior to helical scanning uniquely f...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000289
更新日期:2015-11-01 00:00:00
abstract::We report a unique case of early-phase Takayasu arteritis in which the vessels demonstrated accumulation of [18F]fluorodeoxyglucose (FDG) on PET scanning. This observation suggests the possible use of FDG-PET for the diagnosis of vasculitis. Early diagnosis of Takayasu arteritis may permit early treatment and possibly...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199901000-00004
更新日期:1999-01-01 00:00:00
abstract::A headholder system is described for use in the correlation of images obtained with positron computed tomography (PCT) and other neuroradiological imaging modalities. Methods are described for defining brain anatomy from PCT images by the use of projection schemes from tomographic data. Cross-correlation of images bet...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198208000-00043
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare chest digital tomosynthesis (DTS) and multidetector computed tomography (MDCT) for the detection of pulmonary ground-glass opacity (GGO) nodules and estimation of radiation dose using an anthropomorphic chest phantom and simulated nodules. MATERIALS AND METHODS:A male...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318266aa71
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:The authors compared multislice CT angiography and selective angiography for the assessment of coronary artery disease. METHODS:In 28 patients, the presence and degree of coronary artery stenoses were determined in coronary segments prepared with beta-blocker for good image quality with multislice CT. RESU...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200209000-00015
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Cardiac strain represents an imaging biomarker of contractile dysfunction. PURPOSE:The purpose of this study was to investigate the diagnostic value of cardiac strain obtained by feature-tracking cardiac magnetic resonance (MR) in acute myocarditis. MATERIALS AND METHODS:Cardiac MR examinations of 46 patie...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000001062
更新日期:2020-07-01 00:00:00
abstract::Effects of inaccurate attenuation correction on quantitation in positron emission computed tomography were investigated by both computer simulation and theoretical analysis, followed by experimental verification with phantom measurements. It was found that, due to the finite width of detector responses, compensation o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::The magnetic resonance appearance of three lesions of focal nodular hyperplasia observed in two patients is reviewed. All three lesions demonstrated isointensity with the liver on the short repetition time (TR) and echo time (TE) spin echo images. One lesion also showed a central area of low signal intensity that path...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198707000-00019
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine the effects of dose reduction and iterative reconstruction (IR) on pulmonary nodule volumetry. METHODS:In this prospective study, 25 patients scheduled for follow-up of pulmonary nodules were included. Computed tomography acquisitions were acquired at 4 dose levels with ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000408
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the interobserver variability of right-to-left ventricular (RV/LV) diameter ratios on computed tomographic pulmonary angiographies at reduced tube potential. METHODS:Consecutive computed tomographic pulmonary angiographies performed at 80 kVp for subjects weighing less than 80 kg...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3182994f37
更新日期:2013-09-01 00:00:00