Abstract:
OBJECTIVE:The aim of this study was to explore the response to neoadjuvant chemotherapy (NAC) in nonconcentric shrinkage pattern of breast cancer (BC) patients using H-magnetic resonance spectroscopy. METHODS:Twenty-five BC patients were the study cohort. All patients received AT-based regimen as first-line treatment. Tumor response to chemotherapy was evaluated after the second and fourth cycles using magnetic resonance imaging and magnetic resonance spectroscopy. Final histopathology following surgery after 4 to 8 cycles of NAC served as a reference. Changes in total choline integral* (tCho) and tumor size in response versus nonresponse groups were compared using the 2-way Mann-Whitney nonparametric test. Receiver operating characteristic (ROC) analyses were undertaken, and the area under the ROC curve compared among them. RESULTS:H-magnetic resonance spectroscopy revealed a negative tCho integral* in 6 cases at the first follow-up and 14 cases at the second follow-up. Based on pathology (Miller-Payne system), there were 16 cases of response, and 9 cases of nonresponse. The tCho integral* was significantly different between the response and nonresponse groups at the second follow-up (P = 0.027). The tumor size changes were not significantly different in the response and nonresponse groups at the second follow-up study (P > 0.05). The comparison of ROC curves among the change in tCho integral* and tumor size at baseline and both follow-ups revealed the maximum area under the ROC curve of the change in tCho integral* to be 0.747 at the second follow-up, sensitivity to be 93.75%, and positive predictive value to be 78.9%. CONCLUSIONS:In nonconcentric shrinkage pattern after NAC of BC, when tumor size is difficult to reflect the response, tCho integral* reduction may be a predictive marker.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Zhou J,Qiao PG,Zhang HT,Li GJ,Jiang ZFdoi
10.1097/RCT.0000000000000647subject
Has Abstractpub_date
2018-01-01 00:00:00pages
12-18issue
1eissn
0363-8715issn
1532-3145journal_volume
42pub_type
杂志文章abstract::Segmentation of vertebral bones in computed tomographic data is important as a first stage of image-based radiological tasks. However, it is a challenging problem to segment an affected spine correctly. In this study, we propose a new method of segmentation of thoracic and lumbar vertebral bodies from thin-slice compu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181b12242
更新日期:2010-01-01 00:00:00
abstract::A case of an unusually large cystic renal cell carcinoma demonstrated on plain film, CT, and magnetic resonance (MR) is presented. Though the origin of huge abdominal tumors can be difficult to determine, the CT and MR findings were able to correctly diagnose the mass as a malignant cystic kidney tumor. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198911000-00026
更新日期:1989-11-01 00:00:00
abstract::Seven cases of Poland syndrome were investigated with CT and/or MR to assess the extent of the muscle abnormalities of the shoulder girdle. In all cases the absence of the sternocostal head of the pectoralis major was clearly shown, as were any associated abnormalities of the pectoralis minor, serratus anterior, and l...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199205000-00019
更新日期:1992-05-01 00:00:00
abstract::This is a comparison of the ability of two quantitative magnetic resonance (MR) indices: (a) the second echo signal drop (SESD) (a simplified index of T2 relaxation times that we have developed); and (b) the previously described lesion/liver signal intensity ratio (LLR) to provide histologic diagnosis in hepatic lesio...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::The design of a high resolution positron emission tomograph is described. The scanner has four rings of detectors with an inside diameter of 38 cm and produces seven simultaneous slices, including three cross-slices. Each ring contains 128 bismuth germanate scintillation detectors with dimensions of 8.25 x 20 x 35 mm;...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198002000-00002
更新日期:1980-02-01 00:00:00
abstract::A case of Ebstein anomaly in a 2-day-old newborn is presented. The complementary roles of two-dimensional Doppler echocardiography and magnetic resonance imaging in managing this cardiac malformation are emphasized. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199009000-00032
更新日期:1990-09-01 00:00:00
abstract::We studied four patients with adrenocorticotropic hormone (ACTH)-independent hypercortisolism due to bilateral massive enlargement of the adrenal glands. The combined weight of the adrenal glands ranged from 69 to 149 g and the adrenal cortex was replaced in three of four patients by multiple nodules ranging from micr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-199109000-00009
更新日期:1991-09-01 00:00:00
abstract::Dural venous thrombosis can have a rapidly progressive fatal course if unrecognized; its clinical picture is often confusing. Numerous CT, magnetic resonance (MR), and angiographic findings have been described to help recognize this entity. We present a case of dilated transcerebral medullary veins as a sign of superi...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198711000-00028
更新日期:1987-11-01 00:00:00
abstract::We reviewed the CT of 20 patients with peripheral lung malignancies in which CT appearance suggested chest wall invasion on the basis of extension of mass around ribs into fat or muscle of the chest wall, or definite bone destruction. We correlated these findings with other radiographic studies and surgical and autops...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198703000-00019
更新日期:1987-03-01 00:00:00
abstract::Masses arising in the adrenal gland may be simulated on computed tomography (CT) by a number of anatomical structures and variations, and by certain pathological conditions in adjacent organs. These adrenal pseudotumors include the following: fluid-filled gastric fundus, prominent splenic lobulations, upper pole renal...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198204000-00009
更新日期:1982-04-01 00:00:00
abstract:OBJECTIVES:This study aimed to assess if dual-energy computed tomography (DECT) quantitative analysis and radiomics can differentiate normal liver, hepatic steatosis, and cirrhosis. MATERIALS AND METHODS:Our retrospective study included 75 adult patients (mean age, 54 ± 16 years) who underwent contrast-enhanced, dual-...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000989
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To present a novel magnetic resonance (MR) method of analysis of cerebrospinal fluid (CSF) flow dynamics. METHODS:Fifty-one subjects were explored with phase-contrast cine MR imaging. There were 36 volunteers, 9 patients with normal pressure hydrocephalus (NPH), and 6 patients with asymptomatic ventricular d...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200403000-00015
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:To assess intraobserver and interobserver variability in cardiac computed tomographic measurements of global biventricular function, left ventricular (LV) regional wall motion, systolic wall thickening, and first pass perfusion in 3 patient cohorts at very low, low to intermediate, and intermediate to high c...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31817c4259
更新日期:2009-03-01 00:00:00
abstract::Coronary artery disease is currently the largest killer in the western world, and is estimated to become the leading cause of death worldwide by the year 2020. The question therefore is whether magnetic resonance imaging currently has a place in the already extremely well equipped armamentarium of cardiac testing. Alt...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-199911001-00019
更新日期:1999-11-01 00:00:00
abstract::Serial computed tomography (CT) demonstrated complete resolution of severe periventricular hypodensity occurring in a child after receiving prophylaxis for acute lymphocytic leukemia. The resolution of this encephalopathy suggests that early changes of subacute necrotizing leukoencephalopathy are reversible and CT is ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-197809000-00023
更新日期:1978-09-01 00:00:00
abstract::Fallopian tube carcinoma is an unusual gynecologic malignancy that is rarely diagnosed preoperatively. We report a case of fallopian tube carcinoma occurring in a patient who had undergone a hysterectomy many years previously, in whom findings on computed tomography and ultrasound were highly suggestive of the diagnos...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-200305000-00011
更新日期:2003-05-01 00:00:00
abstract::The diagnosis of scleral perforation of the globe following ocular trauma is often obvious on physical examination, but occult perforations occur frequently. In addition to locating intraorbital foreign bodies and associated facial bone fractures, computed tomography of the orbit can suggest an occult scleral rupture....
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198310000-00022
更新日期:1983-10-01 00:00:00
abstract:PURPOSE:The purpose of this work was to determine the sensitivity of hepatic digital subtraction arteriography (DSA) for the detection of hepatocellular carcinoma (HCC) and dysplastic nodules (DNs) when compared with pathological findings from whole liver explants. METHOD:Twenty-one patients 30-72 years old (mean 54 y...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200007000-00022
更新日期:2000-07-01 00:00:00
abstract::The primitive trigeminal artery is the most common of the persistent carotid-basilar anastomoses with an angiographic incidence of 0.6%. Fifteen cases of aneurysms of a persistent primitive trigeminal artery have been reported in the literature. A 16th patient is presented in whom an incidental trigeminal artery aneur...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-198809010-00022
更新日期:1988-09-01 00:00:00
abstract:PURPOSE:To assess radiation dose reduction and image quality for weight-based chest computed tomographic (CT) examination results reconstructed using adaptive statistical iterative reconstruction (ASIR) technique. MATERIALS AND METHODS:With local ethical committee approval, weight-adjusted chest CT examinations were p...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181b26c67
更新日期:2010-01-01 00:00:00
abstract::Hepatocellular carcinoma and cholangiocarcinoma are the most common primary liver malignancies in adults (comprising >85%); however, liver is also host to some unusual primary malignant tumors. Some of these tumors show distinct demographic, clinicopathologic, and imaging features. Imaging features of these uncommon p...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0000000000000382
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to demonstrate the feasibility of whole-body diffusion tensor imaging (DTI) as a promising tool for research applications, for instance, for investigation of systemic muscle diseases. MATERIALS AND METHODS:Twelve healthy volunteers (mean age, 26.6 years; range, 20-39 years) underwen...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000324
更新日期:2016-01-01 00:00:00
abstract::Computed tomography has had an increasing role in the evaluation of patients after blunt trauma. Important findings in thoracic trauma include acute traumatic aortic injury, pneumothorax, hemothorax, pulmonary contusions and lacerations, mediastinal hematoma, and diaphragmatic rupture. The solid abdominal viscera may ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/01.rct.0000120858.80935.59
更新日期:2004-07-01 00:00:00
abstract::We present a case of a clinically suspected cerebral infarction that was diagnosed as a seizure focus on pulsed arterial spin labeling. The finding of hyperperfusion with perfusion imaging significantly impacted clinical management of the patient. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31814cf81f
更新日期:2008-03-01 00:00:00
abstract::Computed tomography (CT) has been performed in 21 patients with primary hyperparathyroidism (HPT) in an attempt to localize preoperatively the parathyroid tumors. Eighteen of these patients also had ultrasound examinations. The CT examinations included the neck and mediastinum and were performed before and after contr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198206000-00016
更新日期:1982-06-01 00:00:00
abstract::The magnetic resonance (MR) cine display of flexion and extension (F/E) manoeuvres in the cervical spine has proved useful in the evaluation of cord compression due to bone and joint instability, spondylosis, and multiple tumours. It has advantages over X-ray F/E and CT myelography in that it is noninvasive and produc...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198811000-00008
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVES:Our aim was to evaluate the diagnostic accuracy of 256-slice, high-pitch mode multidetector computed tomography (MDCT) for coronary artery bypass graft (CABG) patency. METHODS:Eighty-eight patients underwent 256-slice MDCT angiography to evaluate their graft patency after CABG surgery using a prospectively ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3182a58a8c
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:MRI offers many opportunities for noninvasive in vivo measurement of structure-function relationships in the human brain. Although automated methods are now available for whole-brain measurements, an efficient and valid automatic method for volume estimation of subregions such as the frontal or temporal lobes...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199601000-00018
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to assess the objective and subjective qualities of the contrast-enhanced 4-dimensional dual-energy computed tomography using adaptive statistical iterative reconstruction (ASiR) and ASiR-V. METHODS:The virtual monochromatic images at 60 keV were reconstructed using filtered ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000942
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Dynamic MRI was used to analyze patterns of contrast enhancement in muscle layers in the normal uterine body and to evaluate the depth of myometrial invasion by endometrial carcinoma. MATERIALS AND METHODS:Dynamic MRI was performed in 18 normal volunteers and 22 patients with endometrial carcinoma. Eight of ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199401000-00017
更新日期:1994-01-01 00:00:00