Pulmonary Nodule Volumetry at Different Low Computed Tomography Radiation Dose Levels With Hybrid and Model-Based Iterative Reconstruction: A Within Patient Analysis.

Abstract:

OBJECTIVE:The aim of the study was to determine the effects of dose reduction and iterative reconstruction (IR) on pulmonary nodule volumetry. METHODS:In this prospective study, 25 patients scheduled for follow-up of pulmonary nodules were included. Computed tomography acquisitions were acquired at 4 dose levels with a median of 2.1, 1.2, 0.8, and 0.6 mSv. Data were reconstructed with filtered back projection (FBP), hybrid IR, and model-based IR. Volumetry was performed using semiautomatic software. RESULTS:At the highest dose level, more than 91% (34/37) of the nodules could be segmented, and at the lowest dose level, this was more than 83%. Thirty-three nodules were included for further analysis. Filtered back projection and hybrid IR did not lead to significant differences, whereas model-based IR resulted in lower volume measurements with a maximum difference of -11% compared with FBP at routine dose. CONCLUSIONS:Pulmonary nodule volumetry can be accurately performed at a submillisievert dose with both FBP and hybrid IR.

journal_name

J Comput Assist Tomogr

authors

den Harder AM,Willemink MJ,van Hamersvelt RW,Vonken EP,Schilham AM,Lammers JW,Luijk B,Budde RP,Leiner T,de Jong PA

doi

10.1097/RCT.0000000000000408

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

578-83

issue

4

eissn

0363-8715

issn

1532-3145

journal_volume

40

pub_type

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