Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-beta 1.

abstract：:Numerous studies have reported that long noncoding RNA (lncRNA) dysregulation is involved in the progression of many malignant tumors, including glioma. The lncRNA ZNFX1 antisense RNA 1 (ZFAS1) plays an oncogenic role in various malignant tumors, such as gastric cancer and hepatocellular carcinoma. However, the underl...

journal_title：Journal of cellular physiology

authors： Li X,Luo Y,Liu L,Cui S,Chen W,Zeng A,Shi Y,Luo L

更新日期：2020-03-01 00:00:00

abstract：:The p53 protein directly regulates the expression of the WAF1 (wild-type p53-activated fragment 1) protein which is a cyclin-dependent kinase inhibitor (CDK1). DNA damaging agents such as ionizing or UV radiation, and some chemical agents induce WAF1 in wild-type p53 containing cells, thereby halting cell cycle progre...

journal_title：Journal of cellular physiology

authors： Shiohara M,Akashi M,Gombart AF,Yang R,Koeffler HP

更新日期：1996-03-01 00:00:00

abstract：:Chronic hyperglycemia and activation of receptor for advanced glycation end products (RAGE) are known risk factors for microvascular disease development in diabetic retinopathy. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin (TRX), plays a causative role in diabetes and its...

journal_title：Journal of cellular physiology

authors： Perrone L,Devi TS,Hosoya K,Terasaki T,Singh LP

更新日期：2009-10-01 00:00:00

abstract：:The cellular basis of the membrane-limited state of glucose utilization and the mechanism of the endogenous regulation of hexose uptake in dense monolayers of C6 glioma cells were investigated. In an earlier study, it was shown that at high rates of glucose transport and phosphorylation combined with the inhibition of...

journal_title：Journal of cellular physiology

authors： Lange K,Brandt U,Keller K,Zimmermann B

更新日期：1989-07-01 00:00:00

abstract：:Increased neovascularization is commonly observed in hemorrhagic plaques and associated with rupture of atherosclerotic lesions. This study aims to investigate whether hemin accumulated at the site of hematoma promotes neovascularization through affecting the growth and function of endothelial progenitor cells (EPCs) ...

journal_title：Journal of cellular physiology

authors： Wang JY,Lee YT,Chang PF,Chau LY

更新日期：2009-06-01 00:00:00

abstract：:Tyrosine hydroxylase (TH), catalyzing the conversion of tyrosine into l-DOPA, is the rate-limiting enzyme in dopamine synthesis. Defects in insulin action contribute to alterations of TH expression and/or activity in the brain and insulin increases TH levels in 1-methyl-4-phenylpyridinium (MPP+)-treated neuronal cells...

journal_title：Journal of cellular physiology

authors： Fiory F,Mirra P,Nigro C,Pignalosa FC,Zatterale F,Ulianich L,Prevete N,Formisano P,Beguinot F,Miele C

更新日期：2019-07-01 00:00:00

abstract：:Glucose deprivation, a pathophysiological cell condition, causes up-regulation of GRP78 and induction of etoposide resistance in human cancer cells. The induction of drug resistance can be partly explained by the fact that GRP78 can block activation of caspase-7 induced by treatment with etoposide. Therefore, downregu...

journal_title：Journal of cellular physiology

authors： Hwang JH,Kim JY,Cha MR,Ryoo IJ,Choo SJ,Cho SM,Tsukumo Y,Tomida A,Shin-Ya K,Hwang YI,Yoo ID,Park HR

更新日期：2008-04-01 00:00:00

abstract：:Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. M...

journal_title：Journal of cellular physiology

authors： Vandenburgh HH,Shansky J,Karlisch P,Solerssi RL

更新日期：1993-04-01 00:00:00

abstract：:Activated hepatic stellate cells promote hepatocellular carcinoma (HCC) progression. Hepatic stellate cells play a key role in retinoid metabolism, and activation of stellate cells increases retinoic acid (RA) in the liver. However, the role of RA in HCC proliferation remains unclear. We aimed to analyse the mechanism...

journal_title：Journal of cellular physiology

authors： Lin HH,Peng YJ,Tsai MJ,Wu YY,Tsai TN,Huang HH,Shih YL,Chang WK,Hsieh TY

更新日期：2020-02-01 00:00:00

abstract：:The interaction of basic FGF (bFGF) with heparin, heparan sulfate and related sugars can potentiate or antagonize bFGF activity, depending on the size of the saccharide used. Oligosaccharides based on heparin structures, as small as six sugar residues, have been demonstrated to bind to bFGF and block its activity, whi...

journal_title：Journal of cellular physiology

authors： Foxall C,Wei Z,Schaefer ME,Casabonne M,Fugedi P,Peto C,Castellot JJ Jr,Brandley BK

更新日期：1996-09-01 00:00:00

abstract：:Low-power laser irradiation (LPLI) has been shown to exert promotive effects on cell survival and proliferation through activation of various signaling pathways. Estrogen receptors (ERs, ERα, and ERβ) are ligand-activated transcription factors, which regulate target gene expression, promote cell proliferation, and res...

journal_title：Journal of cellular physiology

authors： Huang L,Tang Y,Xing D

更新日期：2013-05-01 00:00:00

abstract：:Osteoporosis (OP) is a metabolic disease caused by multiple factors, which is characterized by a reduction of bone mass per unit volume and destruction of bone microstructure. Aberrant osteoclast function is the main cause of OP, therefore, regulating the differentiation and function of osteoclast is one of the treatm...

journal_title：Journal of cellular physiology

authors： Xiao Y,Li K,Wang Z,Fu F,Shao S,Song F,Zhao J,Chen W,Liu Q,Xu J

更新日期：2019-08-01 00:00:00

abstract：:Intramedullary stabilization is frequently used to treat long bone fractures. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable deg...

journal_title：Journal of cellular physiology

authors： Li D,Yu K,Xiao T,Dai Y,Liu L,Li H,Jiang D,Xiong L

更新日期：2019-11-01 00:00:00

abstract：:Silibinin is the primary active compound in silymarin. It has been demonstrated to exert anti-carcinogenic effects and hepato-protective effects. However, the effects of silibinin on the maturation and immunostimulatory activities exhibited by dendritic cells (DCs) remain, for the most part, unknown. In this study, we...

journal_title：Journal of cellular physiology

authors： Lee JS,Kim SG,Kim HK,Lee TH,Jeong YI,Lee CM,Yoon MS,Na YJ,Suh DS,Park NC,Choi IH,Kim GY,Choi YH,Chung HY,Park YM

更新日期：2007-02-01 00:00:00

abstract：:Conditions have been established under which the antizyme of ornithine decarboxylase (E.C. 4.1.1.17, L-ornithine carboxy-lyase, ODC) a non-competitive protein inhibitor of ODC, can be detected in cells in response to as little as 10(-7) M putrescine. The maintenance of intracellular antizyme activity depends upon the ...

journal_title：Journal of cellular physiology

authors： Heller JS,Canellakis ES

更新日期：1981-05-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2), a member of transforming growth factor-beta superfamily, plays a crucial role in migration and metastasis of human cancer cells. Integrins are the major adhesive molecules in mammalian cells. Here we found that BMP-2 directed the migration and increased cell surface and mRNA expre...

journal_title：Journal of cellular physiology

authors： Fong YC,Li TM,Wu CM,Hsu SF,Kao ST,Chen RJ,Lin CC,Liu SC,Wu CL,Tang CH

更新日期：2008-12-01 00:00:00

abstract：:Interleukin (IL)-8 is released both in visceral adipose tissue and in contracting skeletal muscles. In this study, we examined cellular pathways associated with muscle hypertrophy, chosen on the basis of microRNA profiling, in differentiating rat primary skeletal muscle cells (RSkMC) treated with IL-8 (1 ng/ml) for 11...

journal_title：Journal of cellular physiology

authors： Milewska M,Domoradzki T,Majewska A,Błaszczyk M,Gajewska M,Hulanicka M,Ciecierska A,Grzelkowska-Kowalczyk K

更新日期：2019-11-01 00:00:00

abstract：:Normal human keratinocytes (NHK) were cultured in serum-free medium, containing low (0.1 mM) or high (2 mM) calcium, to obtain proliferating and differentiating cultures, respectively. Proteoglycan (PG) synthesis of proliferating and differentiating NHK was investigated. Cultures were labeled with 35S-sulfate, and the...

journal_title：Journal of cellular physiology

authors： Rahemtulla F,Moorer CM,Wille JJ Jr

更新日期：1989-07-01 00:00:00

abstract：:Withangulatin A is a newly identified in vitro topoisomerase II inhibitor isolated from the Chinese antitumor herb Physalis angulata. In vivo, it was found to be cytotoxic, capable of suppressing general protein synthesis and of inducing the synthesis of a small set of proteins including those generated by heat-shock ...

journal_title：Journal of cellular physiology

authors： Lee WC,Lin KY,Chen CM,Chen ZT,Liu HJ,Lai YK

更新日期：1991-10-01 00:00:00

abstract：:Neuropathic pain (NP) may cause serious brain diseases, but the genes associated with the metabolic pathway and transcript factors of NP remain unclear. This study is aimed to identify the therapy target genes for NP and to investigate the metabolic pathways and transcript factors associated with NP. The differentiall...

journal_title：Journal of cellular physiology

authors： Yan XT,Xu Y,Cheng XL,He XH,Wang Y,Zheng WZ,Zhao Y,Chen H,Wang YL

更新日期：2019-05-01 00:00:00

abstract：:Several studies have shown that interleukin-4 (IL-4) down-regulates synthesis of prostaglandin E2 (PGE2). We evaluated the mechanisms for this suppression in human alveolar macrophages (HAMs). Normal HAMs were obtained from healthy nonsmoking volunteers. The cells either remained unstimulated, or were exposed to 10 mi...

journal_title：Journal of cellular physiology

authors： Yano T,Hopkins HA,Hempel SL,Monick M,Hunninghake GW

更新日期：1995-10-01 00:00:00

abstract：:Heart failure is a major cause of death throughout the world. Hyperthyroidism has been shown to induce cardiac hypertrophy, which is a contributing factor to heart failure. However, the mechanism underling effect of thyroid hormone is not completely clear. The present study investigates the role of peroxisome prolifer...

journal_title：Journal of cellular physiology

authors： Xu W,Hou D,Jiang X,Lu Z,Guo T,Liu Y,Wang D,Zen K,Yu B,Zhang CY

更新日期：2012-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) have spurred considerable interest in numerous tumors. We aimed to investigate the clinical, prognostic, and diagnostic roles of circRNAs in human lung cancer. We systematically searched PubMed, Web of Science, EMBASE, Scopus, CBM, and the Cochrane Library databases up to July 24, 2018. Eligib...

journal_title：Journal of cellular physiology

authors： Huang X,Zhang W,Shao Z

更新日期：2019-08-01 00:00:00

abstract：:Mouse epidermal cells can be grown as a proliferating monolayer in medium containing 0.02-0.1 mM calcium. Terminal differentiation of these cells with formation of cornified cells and cell death is induced by elevating calcium in the medium to greater than 0.1 mM. A variety of agents were studied as potential modifier...

journal_title：Journal of cellular physiology

authors： Hennings H,Holbrook KA,Yuspa SH

更新日期：1983-09-01 00:00:00

abstract：:Autophagy is a crucial cellular homeostatic process and an important part of the host defense system. Dysfunction in autophagy enhances tissue susceptibility to infection and multiple diseases. However, the role of nucleotide oligomerization domain 1 (NOD1) in autophagy in bovine hepatocytes is not well known. Therefo...

journal_title：Journal of cellular physiology

authors： Roy AC,Chang G,Roy S,Ma N,Gao Q,Shen X

更新日期：2020-12-24 00:00:00

abstract：:The ultimate destiny of a cell to undergo division, differentiation, survival, and death results from an intricate balance between multiple regulators including oncogenes, tumor suppressor genes, and cell cycle associated proteins. Deregulation of the cell cycle machinery switches the phenotype from a normal cell to a...

journal_title：Journal of cellular physiology

authors： Tonini T,Hillson C,Claudio PP

更新日期：2002-08-01 00:00:00

abstract：:Serum stimulation of quiescent 3T3 cells returns the cells to a proliferative state. Changes in Ca content, transport and distribution during the transition through G1 and S phase have been investigated following serum stimulation of these cells. 45 Ca exchange data indicate at least two kinetically defined cellular c...

journal_title：Journal of cellular physiology

authors： Tupper JT,Del Rosso M,Hazelton B,Zorgniotti F

更新日期：1978-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ coactivator-1 deficient (Pgc-1β-/- ) murine hearts model the increased, age-dependent, ventricular arrhythmic risks attributed to clinical conditions associated with mitochondrial energetic dysfunction. These were accompanied by compromised action potential (AP) upstroke ra...

journal_title：Journal of cellular physiology

authors： Ahmad S,Valli H,Smyth R,Jiang AY,Jeevaratnam K,Matthews HR,Huang CL

更新日期：2019-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a newly identified class of small regulatory non-coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating many protein-coding genes and spec...

journal_title：Journal of cellular physiology

authors： Chen D,Farwell MA,Zhang B

更新日期：2010-11-01 00:00:00

abstract：:Prostate cancer (PCa) is the second leading cause of death among American men. Increasing evidence has shown that long noncoding RNAs (lncRNAs) play important roles in tumorigenesis of PCa. In this study, we explored the biological functions of small nucleolar RNA host gene 12 (SNHG12) and investigated the interaction...

journal_title：Journal of cellular physiology

authors： Cheng G,Song Z,Liu Y,Xiao H,Ruan H,Cao Q,Wang K,Xiao W,Xiong Z,Liu D,Chen K,Zhang X

更新日期：2020-02-01 00:00:00