Abstract：
:Effects of redox reagents on excitatory and inhibitory synaptic responses as well as on the bidrectional plasticity of alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor-mediated synaptic responses were studied in CA1 pyramidal neurons in rat hippocampal slices. The oxidizing agent 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB, 200 microM) did not affect AMPA, GABAA or GABAB receptor-mediated synaptic responses or the activation of presynaptic metabotropic receptors. However, DTNB irreversibly decreased (by approximately 50%) currents evoked by focal application of NMDA. DTNB also decreased the NMDA component of the EPSC. The reversal potential of NMDA currents and the Mg2+ block were not modified. In the presence of physiological concentrations of Mg2+ (1.3 mM), DTNB did not affect the NMDA receptor-dependent induction of long-term potentiation (LTP) or long-term depression (LTD) expressed by AMPA receptors. In contrast, DTNB fully prevented LTP and LTD induced and expressed by NMDA receptors. Plasticity of NMDA receptor-mediated synaptic responses could be reinstated by the reducing agent tris-(2-carboxyethyl) phosphine (TCEP, 200 microM). These results suggest that persistent, bidirectional changes in synaptic currents mediated by NMDA receptors cannot be evoked when these receptors are in an oxidized state, whereas NMDA-dependent LTP and LTD are still expressed by AMPA receptors. Our observations raise the possibility of developing therapeutic agents that would prevent persistent excitotoxic enhancement of NMDA receptor-mediated events without blocking longterm modifications of AMPA receptor-mediated synaptic responses, thought to underlie memory processes.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Bernard CL,Hirsch JC,Khazipov R,Ben-Ari Y,Gozlan Hdoi
10.1007/BF02450332subject
Has Abstractpub_date
1997-02-01 00:00:00pages
343-52issue
2eissn
0014-4819issn
1432-1106journal_volume
113pub_type
杂志文章abstract：:A magnetic stimulus applied to the human scalp over the motor cortex causes a short latency contraction of contralateral limb muscles. This is presumed to result from the indirect excitation of corticospinal neurons with monosynaptic connections to motoneurons. The excitability of these cortical neurons can be estimat...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247369
更新日期：1989-01-01 00:00:00
abstract：:Quantitative autoradiography was used to examine central binding sites for L-[3H]glutamate in amygdaloid-kindled rats since receptors for excitatory amino acids have been implicated in epileptiform activity and seizure behaviors. In tissue from rats killed five days after two kindled seizures, the ipsilateral hippocam...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231751
更新日期：1991-01-01 00:00:00
abstract：:Eye and head movements in the horizontal, frontal and sagittal planes were recorded in the rabbit with a newly developed technique using dual scleral search coils in a rotating magnetic field. The compensatory eye movements elicited by passive sinusoidal oscillation deteriorated for frequencies below 0.1 Hz in the hor...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236282
更新日期：1984-01-01 00:00:00
abstract：:Eight 10-year-old children manifesting movement co-ordination problems (MCP), as assessed by the Movement Assessment Battery for Children (MABC), and a matched control group of eight children of a similar age without such problems, were required to carry out a laboratory ball-catching task. The task was constrained in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1193-7
更新日期：2002-11-01 00:00:00
abstract：:Directional preferences have previously been demonstrated during horizontal arm movements. These preferences were characterized by a tendency to exploit interaction torques for movement production at the shoulder or elbow, indicating that the preferred directions depend on biomechanical, and not on visual perception-b...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3766-z
更新日期：2014-02-01 00:00:00
abstract：:The neuronal responsiveness to three-dimensional (3D) motion in cat posteromedial lateral suprasylvian (PMLS) cortex was studied using a computer-controlled, stereoscopic 3D graphic display capable of reproducing the major visual cues for natural 3D motion, including motion disparity, size, texture, and shading change...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050509
更新日期：1998-09-01 00:00:00
abstract：:In the present article, we summarize the recent progress on investigating the mechanism of corticofugal modulation on the auditory thalamus of mammals excluding the bat as it has a specialized auditory system. The article comprises: (1) a review of the anatomy and physiology of the auditory thalamus, and a discussion ...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-003-1680-5
更新日期：2003-12-01 00:00:00
abstract：:The aim of this study was to investigate, in healthy subjects, the modulation of amplitude and phase precision of the auditory steady-state response (ASSR) to 40 Hz stimulation in two resting conditions varying in the level of arousal. Previously, ASSR measures have shown to be affected by the level of arousal, but th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1111-0
更新日期：2007-10-01 00:00:00
abstract：:In order to examine the stability and patterning of speech movement sequences, movements of the lip were recorded as subjects produced a phrase at normal, fast, and slow rates. Three methods of analysis were employed. First, a new index of spatiotemporal stability was derived by summing the standard deviations compute...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00231983
更新日期：1995-01-01 00:00:00
abstract：:In the original publication of the article, Fig. 3 is incorrect. ...
journal_title：Experimental brain research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00221-020-05838-3
更新日期：2020-09-01 00:00:00
abstract：:The aim of the present study was to further investigate the contribution of primary muscle spindle feedback to proprioception and higher brain functions, such as movement trajectory recognition. For this purpose, complex illusory movements were evoked in subjects by applying patterns of muscle tendon vibration mimicki...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0325-2
更新日期：2006-06-01 00:00:00
abstract：:Percutaneous electrical stimulation of the motor point of the first dorsal interosseous muscle (FDI) was used to produce a non-painful contraction of the FDI muscle that caused index finger abduction movement but no radiating cutaneous paraesthesias or sharp sensations localized to joints. Pairs of stimuli separated b...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-2353-3
更新日期：2005-10-01 00:00:00
abstract：:The present study aimed at determining whether the observation of two functionally compatible artefacts, that is which potentially concur in achieving a specific function, automatically activates a motor programme of interaction between the two objects. To this purpose, an interference paradigm was used during which a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3047-2
更新日期：2012-05-01 00:00:00
abstract：:Quantitative studies were made of the distribution of labeled intracortical axons after focal injections of horseradish peroxidase (HRP) into mouse barrel cortex, in vitro. The pattern of labeled fibers was compared to that of labeled cell bodies with respect to the barrel map in layer IV. We analyzed 4 cortices with ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231244
更新日期：1990-01-01 00:00:00
abstract：:Previous findings have suggested that visuomotor programming can make use of learned size information in experimental paradigms where movement kinematics are quite consistent from trial to trial. The present experiment was designed to test whether or not this conclusion could be generalized to a different manipulation...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00221-002-1250-2
更新日期：2002-12-01 00:00:00
abstract：:Pax genes are important modulators of CNS development. Pax7 and Pax6 polarise the neural tube and regionalise the brain. Pax7 is pivotal in specifying the superior colliculus/tectum, an important centre for integration of visuomotor responses and a target for Pax6+ retinal ganglion cell axons during retinocollicular m...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0735-9
更新日期：2007-04-01 00:00:00
abstract：:Precise left-hand movements take longer than right-hand movements (for right-handers). To quantify how left-hand movements are affected by task difficulty and phase of movement control, we manipulated the difficulty of repetitive speeded aiming movements while participants used the left or right hand. We observed left...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3110-z
更新日期：2012-07-01 00:00:00
abstract：:The aim of this research was to analyse the development of postural reactions to approaching (AOF) and receding (ROF) ground rectilinear optical flows. Optical flows were shaped by a pattern of circular spots of light projected on the ground surface by a texture flow generator. The geometrical structure of the project...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1930-1
更新日期：2004-11-01 00:00:00
abstract：:The primary vagal axons and terminals in the lateral descending trigeminal complex (dlv-DLV complex) in crotaline snakes were studied following HRP injections into the vagal nerve. Labeled fibers and terminals were found in the marginal neuropil, which was made up entirely of unmyelinated fibers, i.e., C fibers. The g...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238160
更新日期：1984-01-01 00:00:00
abstract：:Recent anatomical and physiological studies have suggested that parts of the cingulate cortex are involved in the control of movement. These areas have been collectively termed the cingulate motor area (CMA). Currently almost nothing is known, however, about how neurons in the CMA actually participate in the control o...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210100807
更新日期：2001-09-01 00:00:00
abstract：:We studied visuomotor processing in the middle (MS) and lateral suprasylvian (LS) cortices of the alert cat by making single cell recordings while the cat was working in a behavioral task requiring visual fixation and visually guided eye movements. We found responses with three different components: visual sensory, sa...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02259125
更新日期：1992-01-01 00:00:00
abstract：:The cerebral representation of space depends on the integration of many different sensory inputs. The vestibular system provides one such input and its dysfunction can cause profound spatial disorientation. Using positron emission tomography (PET), we measured regional cerebral perfusion with various vestibular stimul...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00241421
更新日期：1994-01-01 00:00:00
abstract：:Although postural control requires the integration of different sensory cues, little is known about the role of attentional artifacts on the individual's ability to properly respond to postural challenges. This study investigated the effects of concomitant tasks (cognitive and postural) on the relationship between vis...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4762-x
更新日期：2016-12-01 00:00:00
abstract：:In sensory saltation, first reported by Geldard and Sherrick (Science 178:178-179, 1972), a stimulus is displaced towards a second one following closely in time and space as a function of the delay between the stimuli. The distance between stimulus locations is restricted by the extension of sensory fields in the prim...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0190-z
更新日期：2006-03-01 00:00:00
abstract：:The development of the ability to integrate postural adjustments into the gait initiation process was investigated in children, using both kinematic and electromyographic (EMG) analysis. Subjects included children of 1 year of age (1-4 months' walking experience), 2-3 years of age (9-17 months' walking experience), 4-...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1044-6
更新日期：2002-06-01 00:00:00
abstract：:Delay eyeblink conditioning was examined in patients with genetically-defined heredoataxias and age-matched control subjects. 24 patients with spinocerebellar ataxia type 6 (SCA6), type 3 (SCA3), and Friedreich's ataxia (FRDA) participated. SCA6 affects primarily the cerebellum, whereas extracerebellar involvement is ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2181-x
更新日期：2005-04-01 00:00:00
abstract：:Micturition in the decerebrate cat is characterized by a coordinated bladder contraction and a simultaneous decrease in external urethral sphincter (EUS) efferent activity. Without the suppression of EUS activity, voiding is significantly impaired, resulting in a state sometimes referred to as bladder-sphincter dyssyn...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050345
更新日期：1998-04-01 00:00:00
abstract：:The firing of neurons from layers II and III of medial entorhinal cortex (MEC) was examined in relation to the hippocampal theta rhythm in urethane anesthetized and walking rats. 1) MEC neurons showed a significant phase relation to the hippocampal theta rhythm in both walking and urethane anesthetized rats, suggestin...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229252
更新日期：1992-01-01 00:00:00
abstract：:Adult-like fine control of cyclical motor patterns found in locomotion develops into adolescence. Single-leg hopping in place is one such motor pattern where children have demonstrated a reduced capacity to control horizontal motion and match metronome cues. These developmental differences might arise from immature in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05548-5
更新日期：2019-07-01 00:00:00
abstract：:We use a vibrotactile-delayed match-to-sample paradigm to evaluate the effects of interference on working memory. One of the suggested mechanisms through which interference affects performance in working memory is feature overwriting: Short-term representations are maintained in a finite set of feature units (such as ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2501-2
更新日期：2011-02-01 00:00:00
