The impact of cocaine and heroin on the placental transfer of methadone.

Abstract:

BACKGROUND:Methadone is the therapeutic agent of choice for the treatment of opiate addiction in pregnancy. The co-consumption (heroin, cocaine) which may influence the effects of methadone is frequent. Therefore, the impact of cocaine and heroin on the placental transfer of methadone and the placental tissue was investigated under in vitro conditions. METHODS:Placentae (n = 24) were ex-vivo perfused with medium (m) (control, n = 6), m plus methadone (n = 6), m plus methadone and cocaine (n = 6) or m plus methadone and heroin (n = 6). Placental functionality parameters like antipyrine permeability, glucose consumption, lactate production, hormone production (hCG and leptin), microparticles release and the expression of P-glycoprotein were analysed. RESULTS:Methadone accumulated in placental tissue. Methadone alone decreased the transfer of antipyrine from 0.60 +/- 0.07 to 0.50 +/- 0.06 (fetal/maternal ratio, mean +/- SD, P < 0.01), whereas the combination with cocaine or heroin increased it (0.56 +/- 0.08 to 0.68 +/- 0.13, P = 0.03 and 0.58 +/- 0.21 to 0.71 +/- 0.24; P = 0.18). Microparticles (MPs) released from syncytiotrophoblast into maternal circuit increased by 30% after cocaine or heroin (P < 0.05) and the expression of P-glycoprotein in the tissue increased by >or= 49% after any drug (P < 0.05). All other measured parameters did not show any significant effect when methadone was combined with cocaine or heroine. CONCLUSION:The combination of cocaine or heroin with methadone increase antipyrine permeability. Changes of MPs resemble findings seen in oxidative stress of syncytiotrophoblast.

journal_name

Reprod Biol Endocrinol

authors

Malek A,Obrist C,Wenzinger S,von Mandach U

doi

10.1186/1477-7827-7-61

subject

Has Abstract

pub_date

2009-06-11 00:00:00

pages

61

issn

1477-7827

pii

1477-7827-7-61

journal_volume

7

pub_type

杂志文章
  • The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst.

    abstract:BACKGROUND:The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst. METHODS:This observational cohort study included a total of 3091 patients undergoing their first frozen-thawed ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-019-0545-0

    authors: Bu Z,Yang X,Song L,Kang B,Sun Y

    更新日期:2019-11-25 00:00:00

  • Increased NO bioavailability in aging male rats by genistein and exercise training: using 4, 5-diaminofluorescein diacetate.

    abstract:BACKGROUND:Several kinds of anti-oxidants have drawn a lot of intention for their benefits on vascular protection. In addition, it has been demonstrated that exercise training could improve endothelial function by up-regulating endothelial nitric oxide synthase (eNOS) protein. Therefore, the present study aims to inves...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-7-93

    authors: Eksakulkla S,Suksom D,Siriviriyakul P,Patumraj S

    更新日期:2009-09-07 00:00:00

  • Expression of costimulatory molecules in the bovine corpus luteum.

    abstract:BACKGROUND:Bovine luteal parenchymal cells express class II major histocompatibility complex (MHC) molecules and stimulate class II MHC-dependent activation of T cells in vitro. The ability of a class II MHC-expressing cell type to elicit a response from T cells in vivo is also dependent on expression of costimulatory ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-5-5

    authors: Cannon MJ,Davis JS,Pate JL

    更新日期:2007-01-31 00:00:00

  • Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats.

    abstract:BACKGROUND:Endocannabinoids (ECs) are important contributors to implantation and decidualization and are suppressed in early pregnancy. Elevated levels of anandamide (AEA), the endogenous ligand for the CB1 and CB2 receptors (R), interfere with receptivity of the blastocyst. Ang-(1-7) is down-regulated in the implantat...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-13-5

    authors: Brosnihan KB,Pulgar VM,Gallagher PE,Neves LA,Yamaleyeva LM

    更新日期:2015-01-17 00:00:00

  • A retrospective study on IVF outcome in euthyroid patients with anti-thyroid antibodies: effects of levothyroxine, acetyl-salicylic acid and prednisolone adjuvant treatments.

    abstract:BACKGROUND:Anti-thyroid antibodies (ATA), even if not associated with thyroid dysfunction, are suspected to cause poorer outcome of in vitro fertilization (IVF). METHODS:We retrospectively analyzed: (a) the prevalence of ATA in euthyroid infertile women, (b) IVF outcome in euthyroid, ATA+ patients, and (c) the effect ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-7-137

    authors: Revelli A,Casano S,Piane LD,Grassi G,Gennarelli G,Guidetti D,Massobrio M

    更新日期:2009-11-27 00:00:00

  • A pilot trial of large versus small diameter needles for oocyte retrieval.

    abstract:BACKGROUND:This study was designed to determine whether small diameter needles for oocyte retrieval alter oocyte yields in patients undergoing IVF in comparison to standard large diameter needles. METHODS:We conducted a prospective pilot study of 21 consecutive favorable prognosis patients. In each patient one ovary w...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1477-7827-11-22

    authors: Kushnir VA,Kim A,Gleicher N,Barad DH

    更新日期:2013-03-20 00:00:00

  • Tissue- and hormone-dependent progesterone receptor distribution in the rat uterus.

    abstract:BACKGROUND:Estradiol (E2) and progesterone (P) are well known regulators of progesterone receptor (PR) expression in the rat uterus. However, it is not known which receptor subtypes are involved. Little knowledge exist about possible differences in PR regulation through ERalpha or ERbeta, and whether the PR subtypes ar...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-4-47

    authors: Sahlin L,Masironi B,Akerberg S,Eriksson H

    更新日期:2006-09-11 00:00:00

  • Dopamine receptor repertoire of human granulosa cells.

    abstract:BACKGROUND:High levels of dopamine (DA) were described in human ovary and recently evidence for DA receptors in granulosa and luteal cells has been provided, as well. However, neither the full repertoire of ovarian receptors for DA, nor their specific role, is established. Human granulosa cells (GCs) derived from women...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-5-40

    authors: Rey-Ares V,Lazarov N,Berg D,Berg U,Kunz L,Mayerhofer A

    更新日期:2007-10-25 00:00:00

  • Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome.

    abstract:BACKGROUND:Claudin-4 (CLDN4) is one of several proteins that act as molecular mediators of embryo implantation. Recently, we examined immunolabeling of leukemia inhibitory factor (LIF) in the endometrial tissue of 52 IVF patients, and found that LIF staining intensity was strongly correlated with successful pregnancy i...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-7-30

    authors: Serafini PC,Silva ID,Smith GD,Motta EL,Rocha AM,Baracat EC

    更新日期:2009-04-19 00:00:00

  • Is interleukin-18 associated with polycystic ovary syndrome?

    abstract:BACKGROUND:Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation. METHODS:To investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin re...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-9-7

    authors: Yang Y,Qiao J,Li R,Li MZ

    更新日期:2011-01-18 00:00:00

  • NLRP7 contributes to in vitro decidualization of endometrial stromal cells.

    abstract:BACKGROUND:Nucleotide-binding oligomerization domain (NACHT), leucine rich repeat (LRR) and pyrin domain (PYD) 7 containing protein, NLRP7, is a member of the NLR family which serves as innate immune sensors. Mutations and genetic variants of NLRP7 have been found in women with infertility associated conditions, such a...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-017-0286-x

    authors: Huang JY,Yu PH,Li YC,Kuo PL

    更新日期:2017-08-15 00:00:00

  • Membrane-initiated actions of estradiol (E2) in the regulation of LH secretion in ovariectomized (OVX) ewes.

    abstract:BACKGROUND:We demonstrated that E2 conjugated to BSA (E2BSA) induces a rapid membrane-initiated inhibition of LH secretion followed hours later by a slight increase in LH secretion. Whether these actions of E2BSA are restricted to the pituitary gland and whether the membrane-initiated pathway of E2BSA contributes to th...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-8-40

    authors: Arreguin-Arevalo JA,Ashley RL,Wagenmaker ER,Oakley AE,Karsch FJ,Nett TM

    更新日期:2010-05-10 00:00:00

  • Profiling of relaxin and its receptor proteins in boar reproductive tissues and spermatozoa.

    abstract:BACKGROUND:Relaxin levels in seminal plasma have been associated with positive effects on sperm motility and quality, and thus having potential roles in male fertility. However, the origin of seminal relaxin, within the male reproductive tract, and the moment of its release in the vicinity of spermatozoa remain unclear...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-015-0043-y

    authors: Feugang JM,Greene JM,Sanchez-Rodríguez HL,Stokes JV,Crenshaw MA,Willard ST,Ryan PL

    更新日期:2015-05-20 00:00:00

  • The association between leukocytes and sperm quality is concentration dependent.

    abstract:BACKGROUND:To evaluate the association between leukocytes (polymorphonuclear granulocytes -PMNL) and semen parameters at different leukocyte concentrations. METHODS:This was a retrospective clinical study at a university hospital andrology clinic. Semen samples from infertile men were analyzed for sperm morphology and...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-8-12

    authors: Lackner JE,Agarwal A,Mahfouz R,du Plessis SS,Schatzl G

    更新日期:2010-02-05 00:00:00

  • A prepartum diet supplemented with oilseeds high in oleic or linoleic acid reduced GnRH-induced LH release in dairy cows during second week postpartum.

    abstract:BACKGROUND:The objective was to determine the effect of prepartum diets supplemented with rolled canola seed (high in oleic acid) or sunflower seed (high in linoleic acid) on luteinizing hormone (LH) pulsatility and gonadotropin releasing hormone (GnRH)-induced LH release during early postpartum. METHODS:Thirty-one pr...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-015-0060-x

    authors: Salehi R,Colazo MG,Oba M,Ambrose DJ

    更新日期:2015-07-03 00:00:00

  • A proteomic analysis of the endometrium in obese and overweight women with recurrent miscarriage: preliminary evidence for an endometrial defect.

    abstract:BACKGROUND:Overweight and obese women have been shown to have an increased risk of recurrent miscarriage as well as other adverse reproductive outcomes, but it is yet unclear whether this is due to an effect on the endometrium, embryo or both. The current study employs proteomic analysis to examine for a potential endo...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-12-75

    authors: Metwally M,Preece R,Thomas J,Ledger W,Li TC

    更新日期:2014-08-05 00:00:00

  • MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma.

    abstract:BACKGROUND:Human uterine leiomyoma (fibroids; LYO) are the most common benign neoplasms in reproductive-aged women. Dysregulated extracellular matrix and irregular LYO reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression are thought to be mediated by aberrant microRNA (miR) expression. The relat...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-016-0180-y

    authors: Guan Y,Guo L,Zukerberg L,Rueda BR,Styer AK

    更新日期:2016-08-17 00:00:00

  • Vitrification preserves chromatin integrity, bioenergy potential and oxidative parameters in mouse embryos.

    abstract:BACKGROUND:The aim of this study was to evaluate the effects of vitrification on morpho-functional parameters (blastomere/chromatin integrity and bioenergy/oxidative potential) of mouse preimplantation embryos. METHODS:In vivo produced mouse (4/16-cell, morulae and blastocyst-stage) embryos were randomly divided into ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-11-27

    authors: Martino NA,Dell'aquila ME,Cardone RA,Somoskoi B,Lacalandra GM,Cseh S

    更新日期:2013-04-03 00:00:00

  • Non-esterified fatty acids in the ovary: friends or foes?

    abstract::A majority of common metabolic diseases can result in excessive lipolysis, leading to elevated levels of non-esterified fatty acids (NEFAs) in the body fluids. In females, increased NEFA levels in the follicular fluid markedly alter the functions of intrafollicular cells such as granulosa cells (GCs) and oocytes. Ther...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,评审

    doi:10.1186/s12958-020-00617-9

    authors: Baddela VS,Sharma A,Vanselow J

    更新日期:2020-06-06 00:00:00

  • The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome.

    abstract:BACKGROUND:To evaluate the relationship between endometrial thickness on day of human chorionic gonadotrophin administration (hCG) and pregnancy outcome in a large number of consecutive in vitro fertilization and embryo transfer (IVF-ET) cycles. METHODS:A retrospective cohort study including all patients who had IVF-E...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-6-37

    authors: Al-Ghamdi A,Coskun S,Al-Hassan S,Al-Rejjal R,Awartani K

    更新日期:2008-09-02 00:00:00

  • The physiology of follicle selection.

    abstract::During the follicular phase of the primate menstrual cycle, a single follicle usually matures to the preovulatory stage and releases its oocyte for fertilization and the potential establishment of pregnancy. In assisted reproductive technology procedures, it is desirable to override the natural process of follicle sel...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,评审

    doi:10.1186/1477-7827-2-31

    authors: Zeleznik AJ

    更新日期:2004-06-16 00:00:00

  • Global gene expression in granulosa cells of growing, plateau and atretic dominant follicles in cattle.

    abstract:BACKGROUND:The physiological state of the dominant follicle is important as it may be linked to the competence of the oocyte within. The objective of this study was to analyze, by transcriptomic analysis, the changes occurring in granulosa cells from dominant follicles at different phases of follicular growth. METHODS...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-015-0010-7

    authors: Girard A,Dufort I,Douville G,Sirard MA

    更新日期:2015-03-08 00:00:00

  • Parental genetic material and oxygen concentration affect hatch dynamics of mouse embryo in vitro.

    abstract:BACKGROUND:Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive researches, how internal and external factors affecting embryo hatch are still largely unclear. METHODS:The...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-018-0356-8

    authors: Zhan S,Cao S,Du H,Sun Y,Li L,Ding C,Zheng H,Huang J

    更新日期:2018-04-21 00:00:00

  • Circulating levels and subcutaneous adipose tissue gene expression of pigment epithelium-derived factor in polycystic ovary syndrome and normal women: a case control study.

    abstract:BACKGROUND:Polycystic ovary syndrome (PCOS) has been recognized as a metabolic disorder, manifested by abdominal obesity, insulin resistance, dyslipidemia and hypertension. Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor family, is a pleiotropic protein known for its antiangiogenic, ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-11-77

    authors: Lecke SB,Morsch D,Spritzer PM

    更新日期:2013-08-14 00:00:00

  • Factors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia.

    abstract:BACKGROUND:Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilati...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-015-0136-7

    authors: Inoue O,Hamatani T,Susumu N,Yamagami W,Ogawa S,Takemoto T,Hirasawa A,Banno K,Kuji N,Tanaka M,Aoki D

    更新日期:2016-01-15 00:00:00

  • Anti-Müllerian hormone serum level and other markers associated with pregnancy outcome in oocyte donation.

    abstract:BACKGROUND:Oocyte donation is a medical technique used principally for woman with ovarian failure. Optimizing donor recruitment is essential to obtain the best results with this technique. Understanding how donor parameters influence outcome for the recipients is fundamental. The aim of this study was to determine whet...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-016-0138-0

    authors: Delesalle AS,Robin G,Thomas-Desrousseaux P,Dewailly D,Catteau-Jonard S

    更新日期:2016-01-19 00:00:00

  • Effects of p-nonylphenol and resveratrol on body and organ weight and in vivo fertility of outbred CD-1 mice.

    abstract::The aim of this study was to analyse the multigenerational effects of para-nonylphenol (NP) and resveratrol (RES) on the body weight, organ weight and reproductive fitness of outbred CD-1 mice. The data indicate that in male mice, NP had an effect on the weight of selected reproductive organs and the kidneys in the pa...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-1-30

    authors: Kyselova V,Peknicova J,Buckiova D,Boubelik M

    更新日期:2003-03-24 00:00:00

  • Luteal and placental function in the bitch: spatio-temporal changes in prolactin receptor (PRLr) expression at dioestrus, pregnancy and normal and induced parturition.

    abstract:BACKGROUND:Endocrine mechanisms governing canine reproductive function remain still obscure. Progesterone (P4) of luteal origin is required for maintenance of pregnancy. Corpora lutea (CL) are gonadotrop-independent during the first third of dioestrus; afterwards prolactin (PRL) is the primary luteotropic factor. Inter...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-9-109

    authors: Kowalewski MP,Michel E,Gram A,Boos A,Guscetti F,Hoffmann B,Aslan S,Reichler I

    更新日期:2011-08-03 00:00:00

  • Expression and regulation of ATF6α in the mouse uterus during embryo implantation.

    abstract:BACKGROUND:ATF6α, one of the sensor proteins in the stress signaling pathway of the endoplasmic reticulum, is located in the membrane of the endoplasmic reticulum. To date, the physiological function of ATF6α in the process of embryo implantation has not been reported. METHODS:In this study, the expression pattern of ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-016-0199-0

    authors: Xiong Y,Li W,Lin P,Wang L,Wang N,Chen F,Li X,Wang A,Jin Y

    更新日期:2016-10-07 00:00:00

  • Spatiotemporal patterns of macrophage migration inhibitory factor (Mif) expression in the mouse placenta.

    abstract:BACKGROUND:Macrophage migration inhibitory factor (MIF) has special pro-inflammatory roles, affecting the functions of macrophages and lymphocytes and counter-regulating the effects of glucocorticoids on the immune response. The conspicuous expression of MIF during human implantation and early embryonic development als...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-8-95

    authors: Faria MR,Hoshida MS,Ferro EA,Ietta F,Paulesu L,Bevilacqua E

    更新日期:2010-08-04 00:00:00