Abstract:
:Tolerance to the analgesic effects of morphine results in part from the development of a compensatory response in neurons that express the opioid receptor or of neural circuits in which those neurons participate. According to this formulation, withdrawal of morphine results in an overshoot of several neuronal properties because of the unopposed action of the compensatory response system. To identify the population of spinal cord neurons that underlies this state, we monitored expression of Fos-like immunoreactivity, after naltrexone-precipitated abstinence in normal and morphine-tolerant rats. After daily (five days) implantation of morphine or placebo pellets, the rats received an injection of saline or naltrexone and behavior was monitored for 1 h. The rats were then killed, their spinal cords removed and 50-microns transverse sections of the lumbar cord were immunostained with a rabbit polyclonal antiserum directed against Fos. Naltrexone injection in the placebo group did not increase spinal cord Fos expression. Naltrexone-precipitated abstinence resulted in an increase in Fos expression at all levels of the spinal cord; the greatest increase and densest staining was in laminae I through VI. Importantly, when withdrawal was precipitated in anesthetized rats, we recorded a significant reduction in Fos expression, particularly in laminae III through VI, but there was persistent expression in the superficial dorsal horn, particularly in lamina I. These results suggest that spinal cord nociresponsive neurons are sensitized during the development of tolerance. This sensitization is unmasked by the administration of naltrexone and is manifested by fos induction in laminae I/II in awake or anesthetized withdrawing animals. The underlying mechanisms of tolerance development may be similar to those that underlie injury-induced central sensitization and hyperalgesia.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Rohde DS,Detweiler DJ,Basbaum AIdoi
10.1016/0306-4522(95)00529-3subject
Has Abstractpub_date
1996-05-01 00:00:00pages
233-42issue
1eissn
0306-4522issn
1873-7544pii
0306452295005293journal_volume
72pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::Amyloid beta peptide (Aβ) is implicated in the development of pathological reactions associated with Alzheimer's disease (AD), such as oxidative stress, neuro-inflammation and death of brain cells. Current pharmacological approaches to treat AD are not able to control the deposition of Aβ and suppression of Aβ-induced...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.03.058
更新日期:2019-06-01 00:00:00
abstract::Evidence suggests the hypothalamic-pituitary-adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to cause glucocorticoid (GC) resistance. In the present study, we aimed to investi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.04.033
更新日期:2020-06-15 00:00:00
abstract::In humans, bromocriptine (BRO) is used as a treatment for many disorders, such as prolactinomas, even during pregnancy and lactation. Previously we demonstrated that maternal BRO treatment at the end of lactation programs offspring for obesity and several endocrine dysfunctions. Here, we studied the long-term effects ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.03.046
更新日期:2016-06-14 00:00:00
abstract::The loss of dopamine neurons combined or not with the subsequent administration of L-DOPA in patients with Parkinson's disease or in experimental models of the disease results in altered GABAergic signaling throughout the basal ganglia, including the striatum and the substantia nigra, pars reticulata. However, the mol...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.12.001
更新日期:2007-03-16 00:00:00
abstract::The cerebellum receives input from visual cortical areas via a relay in the pontine nuclei. We have compared the location in the pontine nuclei of terminal fields of fibres from visual areas 18 and 20, and the posteromedial lateral suprasylvian visual area. Due to individual variations in the precise location of termi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90335-7
更新日期:1989-01-01 00:00:00
abstract::Depression is a chronic disease that affects nearly twice as many women as men, and symptoms can differ by sex. Preclinical models disproportionately use male subjects and test a single behavioral endpoint immediately at the cessation of stress. We conducted variable stress in male and female mice for 6, 28, and 56 da...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.12.034
更新日期:2021-02-01 00:00:00
abstract::Current models of basal ganglia disorders suggest that choreoathetosis is the end result of reduced GABAergic inhibition of the motor thalamus. Graft-derived release of GABA from intrastriatal striatal grafts has also been reported. In the present work, cell suspension grafts from embryonic day 14-15 rat striatal prim...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00181-h
更新日期:1995-10-01 00:00:00
abstract::The amyloid beta precursor protein can exist as both a membrane-bound and a secreted protein, with the former having the potential to generate the amyloid beta peptide present in the neuritic plaques which are characteristic of Alzheimer's disease. In this study, we have used a clone of the AtT20 mouse pituitary cell ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00361-3
更新日期:1999-04-01 00:00:00
abstract::The contributions of several Ca(2+)-dependent processes to neurotoxicity were examined in primary cultures of rat cortical neurons. The Ca2+ ionophore ionomycin induced a rapid loss of axonal morphology and concomitant release of inositol phosphates that preceded morphological alterations of neuronal cell bodies, chol...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00070-0
更新日期:1998-10-01 00:00:00
abstract::The alpha- and beta-stereoisomers of kainate correspond sterically to the L- and D-isomers of glutamate. Alpha-Kainate is a potent excitant at a specific membrane receptor site (kainate receptor). Beta-Kainate has been proposed as a functional N-methyl-D-aspartate antagonist in vivo. Because of the structural similari...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(87)90020-0
更新日期:1987-01-01 00:00:00
abstract::Previous research has demonstrated antidepressant-like effects in rodents upon intracerebral inhibition of histone deacetylases (HDACs). Such effects have been reported for local HDAC inhibition in the nucleus accumbens, hippocampus, and amygdala. However, the effect of HDAC inhibition within the medial prefrontal cor...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.04.030
更新日期:2015-07-09 00:00:00
abstract::The difference in visual object recognition by males and females suggests a sex-specific function in the medial prefrontal cortex (mPFC). In the present study, we performed an in vivo microdialysis study in three groups of rats (males, diestrous females, and proestrous females) to examine the potential sex difference ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.12.039
更新日期:2009-03-03 00:00:00
abstract::Necker cube is one of the ambiguous figures that is physically a static image but can be alternately perceived in two different perspectives. A great deal of debate exists regarding ambiguous figures that induce spontaneous switching between rival percepts. To investigate the time course of neural processes underlying...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.04.015
更新日期:2014-06-20 00:00:00
abstract::Perceptual integration of sensory input from our two nostrils has received little attention in comparison to lateralized inputs for vision and hearing. Here, we investigated whether a binary odor mixture of eugenol and l-carvone (smells of cloves and caraway) would be perceived differently if presented as a mixture in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.10.079
更新日期:2014-01-31 00:00:00
abstract::A dysfunction of noradrenergic mechanisms originating in the locus coeruleus has been hypothesised to be the critical factor underlying the evolution of central neurodegenerative diseases [Colpaert FC (1994) Noradrenergic mechanism Parkinson's disease: a theory. In: Noradrenergic mechanisms in Parkinson's disease (Bri...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00757-1
更新日期:2003-01-01 00:00:00
abstract::Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of (3)H₂O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly fas...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.06.022
更新日期:2013-09-17 00:00:00
abstract::The paraventricular nucleus of the hypothalamus is increasingly being viewed as an important site for cardiovascular integration because of its connections to regions in the brain and spinal cord which are known to be important in cardiovascular control. Like the vasomotor neurons of the rostral ventrolateral medulla,...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00255-3
更新日期:1999-01-01 00:00:00
abstract::Synaptic vesicle recycling is a critical feature of neuronal communication as it ensures a constant supply of releasable transmitter at the nerve terminal. Physiological studies predict that vesicle recycling is rapid and recent studies with fluorescent dyes have confirmed that the entire process may occur in less tha...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/s0306-4522(97)00453-3
更新日期:1998-04-01 00:00:00
abstract::Mice provide a highly valuable resource for investigating learning and memory processes; however, many of the established tasks for evaluating learning and memory were developed for rats. Behaviors of mice in these tasks appear to be driven by different motivational factors, and as a result, they often do not perform ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.12.029
更新日期:2010-03-10 00:00:00
abstract::In vivo voltammetry was used to study the effects of basolateral amygdala dopamine depletion on stress-induced dopamine release in the nucleus accumbens and medial prefrontal cortex. Male Long-Evans rats received bilateral microinjections of 6-hydroxydopamine or vehicle into the basolateral amygdala. Changes in dopami...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00553-5
更新日期:2003-01-01 00:00:00
abstract::Progestins mediate the onset and duration of lordosis, the mating posture of female rodents, through actions in the hypothalamus and ventral tegmental area. In the hypothalamus, progesterone has traditional, "genomic" actions via intracellular progestin receptors. In the ventral tegmental area, 3alpha-hydroxy-5alpha-p...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2005.06.015
更新日期:2006-01-01 00:00:00
abstract::Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vome...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(96)00096-6
更新日期:1996-09-01 00:00:00
abstract::The orexinergic neurons of the lateral hypothalamus (LH) are critical for wakefulness [McCarley RW (2007) Neurobiology of REM and NREM sleep. Sleep Med 8:302-330]. Recent evidence suggests that adenosine (AD), a homeostatic sleep factor, may act via A1 receptor (A1R) to control orexinergic activity and regulate sleep-...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.01.017
更新日期:2008-06-02 00:00:00
abstract::Acute and chronic exposure to psychostimulants results in altered function of G-protein-coupled receptors in the forebrain. It is believed that neuroadaptations in G-protein signaling contribute to behavioral sensitivity to psychostimulants that persists over a prolonged drug-free period. Proteins termed activators of...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.03.013
更新日期:2010-06-16 00:00:00
abstract::Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P. Recently, axonal transport of opiate receptors was found to increase in rat sciatic nerves in the model of Freund's adjuvant-induc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00106-s
更新日期:1995-09-01 00:00:00
abstract::Food restriction has been shown to be beneficial for a number of brain processes. In the current study, we characterized the impact of food restriction on hippocampal damage 70 days following ischemia. We assessed memory and cognitive flexibility of ad libitum fed (AL) and food-restricted (FR) animals using complex de...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.05.062
更新日期:2008-09-22 00:00:00
abstract::The sixth lumbar and first sacral spinal cord segments in the rat contain parasympathetic preganglionic neurons which innervate the pelvic viscera. There have been few studies, however, which have specifically considered the distribution of putative peptide neurotransmitters in these cord segments. The present paper d...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90175-1
更新日期:1984-07-01 00:00:00
abstract::Rats received bilateral lesions of the nucleus basalis magnocellularis by infusion of ibotenic acid. Fourteen days later, osmotic minipumps releasing human recombinant nerve growth factor (0.3 micrograms/day) were implanted subcutaneously. Starting one month after the lesion, spatial learning of the animals was tested...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90342-y
更新日期:1992-01-01 00:00:00
abstract::We describe two distinct mechanisms for the enhancement of plasma extravasation in the knee joint of the rat. One is activated by bradykinin and is neurogenic; the other is activated by platelet-activating factor and is non-neurogenic. Bradykinin-induced synovial plasma extravasation is known to be dependent on the sy...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90422-c
更新日期:1993-02-01 00:00:00
abstract::Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.02.007
更新日期:2020-04-01 00:00:00