9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.

abstract：:Intestinal CD103(-) dendritic cells (DCs) are pathogenic for colitis. Unveiling molecular mechanisms that render these cells proinflammatory is important for the design of specific immunotherapies. In this report, we demonstrated that mesenteric lymph node CD103(-) DCs express, among other proinflammatory cytokines, h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kourepini E,Aggelakopoulou M,Alissafi T,Paschalidis N,Simoes DC,Panoutsakopoulou V

更新日期：2014-03-04 00:00:00

abstract：:Ventricular fibrillation is the leading cause of sudden cardiac death. In fibrillation, fragmented electrical waves meander erratically through the heart muscle, creating disordered and ineffective contraction. Theoretical and computer studies, as well as recent experimental evidence, have suggested that fibrillation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garfinkel A,Kim YH,Voroshilovsky O,Qu Z,Kil JR,Lee MH,Karagueuzian HS,Weiss JN,Chen PS

更新日期：2000-05-23 00:00:00

abstract：:Intracellular granules in several types of leukocytes contain preformed proteins whose secretions contribute to immune and inflammatory functions of leukocytes, including eosinophils, cells notably associated with asthma, allergic inflammation, and helminthic infections. Cytokines and chemokines typically elicit extra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neves JS,Perez SA,Spencer LA,Melo RC,Reynolds L,Ghiran I,Mahmudi-Azer S,Odemuyiwa SO,Dvorak AM,Moqbel R,Weller PF

更新日期：2008-11-25 00:00:00

abstract：:The brain disturbances that place a person at risk for developing depression are unknown. We imaged the brains of 131 individuals, ages 6 to 54 years, who were biological descendants (children or grandchildren) of individuals identified as having either moderate to severe, recurrent, and functionally debilitating depr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson BS,Warner V,Bansal R,Zhu H,Hao X,Liu J,Durkin K,Adams PB,Wickramaratne P,Weissman MM

更新日期：2009-04-14 00:00:00

abstract：:Spleen cells derived from a rabbit hyperimmunized with a Type III pneumococcal vaccine were exposed to simian virus 40 in vitro. After 114 days, transformed cells growing on the surface of one culture dish were observed and a cell line was established. The transformed cells had a morphology characteristic of cells tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins JJ,Black PH,Strosberg AD,Haber E,Bloch KJ

更新日期：1974-02-01 00:00:00

abstract：:We report here the biologically active conformation of acetylcholine when bound to the high-affinity state of the receptor from Torpedo californica. The acetylcholine conformation was determined in the free and bound states by proton NMR two-dimensional nuclear Overhauser effects. In agreement with x-ray crystallograp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Behling RW,Yamane T,Navon G,Jelinski LW

更新日期：1988-09-01 00:00:00

abstract：:The nucleotide sequence of intracellular 26S mRNA of Sindbis virus has been determined by direct sequence analysis of the cDNA made to this RNA with reverse transcriptase. From this, the amino acid sequences of the encoded virus structural proteins, which include a basic capsid protein and two integral membrane glycop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice CM,Strauss JH

更新日期：1981-04-01 00:00:00

abstract：:Because of increased numbers of recorded pertussis cases in the United States, this study sought to understand the role of nonmedical vaccine exemptions and waning immunity may have had on the resurgence of pertussis in the United States at the community level. We used geospatial scan statistics, SaTScan, version 9.4,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aloe C,Kulldorff M,Bloom BR

更新日期：2017-07-03 00:00:00

abstract：:Acetylcholine is the main neurotransmitter at the mammalian neuromuscular junction (NMJ) where nicotinic acetylcholine receptors mediate the signaling between nerve terminals and muscle fibers. We show that under glutamatergic transmission, rat NMJ switches from cholinergic type synapse to glutamatergic synapse. Conne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brunelli G,Spano P,Barlati S,Guarneri B,Barbon A,Bresciani R,Pizzi M

更新日期：2005-06-14 00:00:00

abstract：:Polarization of optical fields is a crucial degree of freedom in the all-optical analogue of electromagnetically induced transparency (EIT). However, the physical origins of EIT and polarization-induced phenomena have not been well distinguished, which can lead to confusion in associated applications such as slow ligh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Jiang X,Sweeney WR,Hsu CW,Liu Y,Zhao G,Peng B,Zhang M,Jiang L,Stone AD,Yang L

更新日期：2021-01-19 00:00:00

abstract：:Selection of mammalian cells in progressively increasing concentrations of methotrexate results in selective amplification of DNA sequences coding for dihydrofolate reductase (tetrahydrofolate dehydrogenase, 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3). In some cell variants the amplified genes are stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman RJ,Brown PC,Schimke RT

更新日期：1979-11-01 00:00:00

abstract：:Among the earliest and most important stages during tumorigenesis is the activation of the angiogenic process, an event that is termed the "switch to the angiogenic phenotype." We have developed an in vivo system that can reliably recapitulate the stages in tumor development that represent this transition. Using this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang J,Shing Y,Wiederschain D,Yan L,Butterfield C,Jackson G,Harper J,Tamvakopoulos G,Moses MA

更新日期：2000-04-11 00:00:00

abstract：:The multifunctional Creb-binding protein (CBP) protein plays a pivotal role in many critical cellular processes. Here we demonstrate that the bromodomain of CBP binds to histone H3 acetylated on lysine 56 (K56Ac) with higher affinity than to its other monoacetylated binding partners. We show that autoacetylation of CB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das C,Roy S,Namjoshi S,Malarkey CS,Jones DN,Kutateladze TG,Churchill ME,Tyler JK

更新日期：2014-03-25 00:00:00

abstract：:Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechanisms underlying circ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuber AM,Centeno G,Pradervand S,Nikolaeva S,Maquelin L,Cardinaux L,Bonny O,Firsov D

更新日期：2009-09-22 00:00:00

abstract：:For decades, scientists have debated whether supercooled liquids stop flowing below a glass transition temperature [Formula: see text] or whether motion continues to slow gradually down to zero temperature. Answering this question is challenging because human time scales set a limit on the largest measurable viscosity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jadhao V,Robbins MO

更新日期：2017-07-25 00:00:00

abstract：:The ability of lysosomes to move within the cytoplasm is important for many cellular functions. This ability is particularly critical in neurons, which comprise vast, highly differentiated domains such as the axon and dendrites. The mechanisms that control lysosome movement in these domains, however, remain poorly und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS

更新日期：2017-04-04 00:00:00

abstract：:The somatostatin receptor subtype 2 (sst2) behaves as a tumor suppressor when expressed and stimulated by its ligand somatostatin in pancreatic cancer. We reveal a mechanism underlying oncosuppressive action of sst2, whereby this inhibitory receptor upregulates the expression of the secreted angioinhibitory factor thr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laklai H,Laval S,Dumartin L,Rochaix P,Hagedorn M,Bikfalvi A,Le Guellec S,Delisle MB,Schally AV,Susini C,Pyronnet S,Bousquet C

更新日期：2009-10-20 00:00:00

abstract：:Emergence of antiestrogen-resistant cells in MCF-7 cells during suppression of estrogen signaling is a widely accepted model of acquired breast cancer resistance to endocrine therapy. To obtain insight into the genomic basis of endocrine therapy resistance, we characterized MCF-7 monoclonal sublines that survived 21-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coser KR,Wittner BS,Rosenthal NF,Collins SC,Melas A,Smith SL,Mahoney CJ,Shioda K,Isselbacher KJ,Ramaswamy S,Shioda T

更新日期：2009-08-25 00:00:00

abstract：:Studies of phage lambda in vivo have indicated that its own recombination enzymes, beta protein and lambda exonuclease, are capable of catalyzing two dissimilar pathways of homologous recombination that are widely distributed in nature: single-strand annealing and strand invasion. The former is an enzymatic splicing o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rybalchenko N,Golub EI,Bi B,Radding CM

更新日期：2004-12-07 00:00:00

abstract：:Superhydrophobic surfaces display water contact angles greater than 150 degrees in conjunction with low contact angle hysteresis. Microscopic pockets of air trapped beneath the water droplets placed on these surfaces lead to a composite solid-liquid-air interface in thermodynamic equilibrium. Previous experimental and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuteja A,Choi W,Mabry JM,McKinley GH,Cohen RE

更新日期：2008-11-25 00:00:00

abstract：:Protein Hal is a human gamma4 heavy-chain disease protein whose molecular weight is reduced from 55,000 to 25,000 in 6 M guanidine due to the lack of disulfide bonds between heavy chains. Studies of aminoacid sequence indicate that it contains a gap of about 240 residues, starting 10 residues from the N-terminal end a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frangione B,Lee L,Haber E,Bloch KJ

更新日期：1973-04-01 00:00:00

abstract：:We have attempted to model human metastatic disease by implanting human target organs into the immunodeficient C.B-17 scid/scid (severe combined immunodeficiency; SCID) mouse, creating SCID-hu mice. Preferential metastasis to implants of human fetal lung and human fetal bone marrow occurred after i.v. injection of hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shtivelman E,Namikawa R

更新日期：1995-05-09 00:00:00

abstract：:Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin presumably in pathological conditions, such as inflammation. Therefore, we have assessed the relative inhibitory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell JA,Akarasereenont P,Thiemermann C,Flower RJ,Vane JR

更新日期：1993-12-15 00:00:00

abstract：:T cells that have been immunized to express optimal levels of contact hypersensitivity upon adoptive transfer to normal animals can be inhibited from doing so by incubating them with an antigen-specific T suppressor factor. This factor is composed of at least two subunits which come from cells expressing different Ly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ptak W,Rosenstein RW,Gershon RK

更新日期：1982-04-01 00:00:00

abstract：:Specific rearrangement of internal chromosomal regions occurs during development of the somatic macronucleus in Tetrahymena thermophila and results in elimination of germ-line (micronuclear) DNA sequences. The timing and mechanism of genome rearrangement within one particular 9.3-kilobase region, which contains three ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austerberry CF,Allis CD,Yao MC

更新日期：1984-12-01 00:00:00

abstract：:Current structural genomics projects are yielding structures for proteins whose functions are unknown. Accordingly, there is a pressing requirement for computational methods for function prediction. Here we present PHUNCTIONER, an automatic method for structure-based function prediction using automatically extracted f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pazos F,Sternberg MJ

更新日期：2004-10-12 00:00:00

abstract：:The product(s) of the Myxococcus xanthus spoC locus is required for two multicellular activities in fruiting body development, rippling and sporulation. Ripples, which are formed early in development, are spatially separated ridges of cells that move synchronously. Myxospores are heat-resistant resting cells that are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimkets LJ,Gill RE,Kaiser D

更新日期：1983-03-01 00:00:00

abstract：:Chromosome 14 was transferred into tumorigenic nasopharyngeal carcinoma and esophageal carcinoma cell lines by a microcell-mediated chromosome transfer approach. Functional complementation of defects present in the cancer cells suppressed tumor formation. A candidate tumor-suppressor gene, cysteine-rich intestinal pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AK,Ko JM,Lung HL,Chan KW,Stanbridge EJ,Zabarovsky E,Tokino T,Kashima L,Suzuki T,Kwong DL,Chua D,Tsao SW,Lung ML

更新日期：2011-05-17 00:00:00

abstract：:Small RNAs (sRNAs) are hypothesized to contribute to hybrid vigor because they maintain genome integrity, contribute to genetic diversity, and control gene expression. We used Illumina sequencing to assess how sRNA populations vary between two maize inbred lines (B73 and Mo17) and their hybrid. We sampled sRNAs from t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber WT,Zhang W,Win H,Varala KK,Dorweiler JE,Hudson ME,Moose SP

更新日期：2012-06-26 00:00:00

abstract：:Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molecular biology to address the major limitations of standard ChIP-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dainese R,Gardeux V,Llimos G,Alpern D,Jiang JY,Meireles-Filho ACA,Deplancke B

更新日期：2020-06-16 00:00:00