Abstract:
:Spleen cells derived from a rabbit hyperimmunized with a Type III pneumococcal vaccine were exposed to simian virus 40 in vitro. After 114 days, transformed cells growing on the surface of one culture dish were observed and a cell line was established. The transformed cells had a morphology characteristic of cells transformed by simian virus 40, contained the simian virus 40-specific T antigen, and yielded infectious simian virus 40 upon cultivation with indicator cells in the presence of Sendai fusion factor. Transformed cells incorporated labeled amino acid into protein with the antigenic properties of rabbit immunoglobulin G.
journal_name
Proc Natl Acad Sci U S Aauthors
Collins JJ,Black PH,Strosberg AD,Haber E,Bloch KJdoi
10.1073/pnas.71.2.260subject
Has Abstractpub_date
1974-02-01 00:00:00pages
260-2issue
2eissn
0027-8424issn
1091-6490journal_volume
71pub_type
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