Abstract:
:Cyclic AMP (CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin-induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta-adrenergic receptor sensitivity. An alteration in lymphocyte beta-adrenergic receptor may reflect similar changes in central beta-adrenergic function and may be used as a probe to evaluate its activity.
journal_name
Headachejournal_title
Headacheauthors
Kuritzky A,Bennet E,Hering R,Ebstein Rdoi
10.1111/j.1526-4610.1993.hed33040198.xsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
198-200issue
4eissn
0017-8748issn
1526-4610journal_volume
33pub_type
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