Reduced sensitivity of lymphocyte beta-adrenergic receptors in migraine.

Abstract:

:Cyclic AMP (CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin-induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta-adrenergic receptor sensitivity. An alteration in lymphocyte beta-adrenergic receptor may reflect similar changes in central beta-adrenergic function and may be used as a probe to evaluate its activity.

journal_name

Headache

journal_title

Headache

authors

Kuritzky A,Bennet E,Hering R,Ebstein R

doi

10.1111/j.1526-4610.1993.hed33040198.x

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

198-200

issue

4

eissn

0017-8748

issn

1526-4610

journal_volume

33

pub_type

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