Flunarizine plasma concentrations and side effects in migraine patients.

abstract：BACKGROUND:Recent studies have found a strong relationship between tobacco smoking and headache pain. It remains unclear whether smoking behavior leads to headache or visa versa, mainly due to the cross-sectional nature of the majority of this research. OBJECTIVE:To help clarify the direction of the relation between s...

journal_title：Headache

authors： Waldie KE,McGee R,Reeder AI,Poulton R

更新日期：2008-04-01 00:00:00

abstract：:This study examined the pharmacokinetics of 300 mg of tiaprofenic acid, a NSAID belonging to the 2-arylpropionic class, as a single oral dose, in 10 migraine patients during and out of migraine attacks. Plasma concentration of tiaprofenic acid was determined by HPLC analysis. Drug absorption appeared to be the same du...

journal_title：Headache

authors： Pini LA,Bertolotti M,Bergonzini G,Casalgrandi L,Giroldi L,Sternieri E

更新日期：1990-10-01 00:00:00

abstract：:This review considers current debate surrounding refractory migraine and poses the question, why do some patients fail to improve with currently available therapies? ...

journal_title：Headache

authors： Dodick DW

更新日期：2008-06-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a ubiquitous neuropeptide found at the very centers of the migraine process, both centrally and peripherally. It has been under careful study for approximately 25 years. Several CGRP-receptor antagonists are being evaluated for acute treatment of episodic migraine. Three monoc...

journal_title：Headache

authors： Bigal ME,Walter S,Rapoport AM

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between hyposerotonin and cranial microvascular responses to nitric oxide (NO). BACKGROUND:Although the mechanism underlying NO supersensitivity in migraine is still unclear, an alteration of the serotonin system is a possible explanation. METHODS:Wistar rats were divided int...

journal_title：Headache

authors： Srikiatkhachorn A,Anuntasethakul T,Maneesri S,Phansuwan-Pujito P,Patumraj S,Kasantikul V

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVES:To describe the occurrence of cerebral venous thrombosis in a 40-year-old man whose cerebral event was induced by a poor golf swing, to review the literature on possible mechanisms producing venous thrombosis, and to compare this case with the literature. BACKGROUND:Headache is the most frequent symptom in ...

journal_title：Headache

authors： Saneto RP,Samples S,Kinkel RP

更新日期：2000-07-01 00:00:00

abstract：:It has been suggested that magnesium (Mg) may play a role in the pathogenesis of headaches. Serum and intracellular measurements of Mg in headache patients have produced inconsistent results. The recent development of an ion-selective electrode for Mg2+ allowed precise measurement of serum ionized magnesium (IMg2+) in...

journal_title：Headache

authors： Mauskop A,Altura BT,Cracco RQ,Altura BM

更新日期：1993-03-01 00:00:00

abstract：:Patients with temporomandibular disorders frequently suffer from headache. The purpose of this study was to develop a simple screening exam which would allow the physician to identify headache patients with coexisting temporomandibular disorders. Twenty-eight migraine and 27 tension headache patients were identified b...

journal_title：Headache

authors： Schiffman E,Haley D,Baker C,Lindgren B

更新日期：1995-03-01 00:00:00

abstract：:Consumption of monosodium glutamate has long been considered to precipitate headaches in susceptible patients. In this study the direct effects of glutamate and its metabolite, glutamine, on arterial contractility were examined using rings of rabbit aorta. In a high concentration glutamate caused significant concentra...

journal_title：Headache

authors： Merritt JE,Williams PB

更新日期：1990-09-01 00:00:00

abstract：:The author reports the use of pregabalin in a patient with glossopharyngeal neuralgia. The patient achieved complete pain relief and tolerated the medication. This is the first published report of the use of this medicine for glossopharyngeal neuralgia. ...

journal_title：Headache

authors： Kitchener JM

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:To report a case of petrous apicitis that manifested as chronic migraine without aura and to discuss the pathophysiological mechanisms behind this presentation. BACKGROUND:Petrous apicitis is a rare complication of acute otitis media with varied clinical presentations that stem from the close proximity of th...

journal_title：Headache

authors： Mancini AJ,Glassman RD,Chang YM,Burstein R,Ashina S

更新日期：2019-11-01 00:00:00

abstract：:We report the case of a 60-year-old woman in whom migraine with typical aura heralded the presence of an occipital lobe tumor. Her headache was characterized by recurrent episodes of visual aura confined to the left visual field followed by right hemicranial throbbing headaches accompanied by nausea, photophobia, and ...

journal_title：Headache

authors： Verma A,Rosenfeld V,Forteza A,Sharma KR

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Recent research has shown that affective changes associated with the menstrual cycle may follow diverse patterns, including a classic premenstrual syndrome pattern, as well as the mirror opposite pattern, referred to as a mid-cycle pattern. OBJECTIVE:Test for the presence of a mid-cycle pattern of headaches...

journal_title：Headache

authors： Kiesner J,Martin VT

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of coumarin therapy on migraine attack frequency. BACKGROUND:Sporadic case reports and clinical studies have described beneficial effects of coumarin therapy on migraine severity. DESIGN AND METHODS:A retrospective follow-up study based on a prescription database covering a populat...

journal_title：Headache

authors： Rahimtoola H,Egberts AC,Buurma H,Tijssen CC,Leufkens HG

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Migraine is a highly disabling disease affecting a significant proportion of the Australian population. The methylenetetrahydrofolate reductase (MTHFR) C677T variant has been associated with increased levels of homocysteine and risk of migraine with aura (MA). Folic acid (FA), vitamin B6 , and B12 supplement...

journal_title：Headache

authors： Menon S,Lea RA,Ingle S,Sutherland M,Wee S,Haupt LM,Palmer M,Griffiths LR

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Despite the expanding therapeutic armamentarium, many people with episodic migraine (EM) have unmet acute treatment needs. OBJECTIVE:To determine the relative frequency of prespecified types of "unmet treatment needs" in persons with EM in a US population-based sample. METHODS:Eligible participants complet...

journal_title：Headache

authors： Lipton RB,Buse DC,Serrano D,Holland S,Reed ML

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To establish if criteria for the diagnosis of migraine change with age and to document the influence of age on the full spectrum of migraine features. Also to define the clinical spectrum and provide a prognostic profile of migraine stratified by age. BACKGROUND:Few studies have formally analyzed migraine ch...

journal_title：Headache

authors： Kelman L

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:To look at the smoking history of migraine patients and to determine if a history of cigarette smoking is associated with the development of cranial autonomic symptoms with migraine headaches. BACKGROUND:It has recently been noted that a significant number of migraine patients may develop autonomic symptoms ...

journal_title：Headache

authors： Rozen TD

更新日期：2011-01-01 00:00:00

abstract：:Discrimination toward people living with migraine and other headache disorders is widespread and socially accepted. Stigma toward these diseases is both a manifestation of these discriminatory attitudes and a sustainer of them. For those living with migraine and headache disorders, stigma limits the full expression of...

journal_title：Headache

authors： Shapiro RE

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:In a randomized controlled trial extending over 6 months, we evaluated the effectiveness of acupuncture versus flunarizine in the prophylactic treatment of migraine without aura. METHODS:One hundred sixty women with migraines were randomly assigned to acupuncture treatment (group A, n = 80) or to an oral th...

journal_title：Headache

authors： Allais G,De Lorenzo C,Quirico PE,Airola G,Tolardo G,Mana O,Benedetto C

更新日期：2002-10-01 00:00:00

abstract：:Seventy-six patients with vascular (migraine or mixed migraine and tension) headache (HA) participated in a controlled evaluation of a minimal-therapist-contact, largely home-based, treatment program which combined relaxation (R) training with thermal biofeedback (TBF). One group received TBF + R administered in 3 off...

journal_title：Headache

authors： Blanchard EB,Appelbaum KA,Nicholson NL,Radnitz CL,Morrill B,Michultka D,Kirsch C,Hillhouse J,Dentinger MP

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To identify and investigate any dysfunction of neuromuscular transmission in episodic cluster headache. BACKGROUND:Abnormal neuromuscular transmission has been shown in migraine with aura and in migraine without aura by using single fiber electromyography. Especially for migraine with aura, a genetic cause h...

journal_title：Headache

authors： Ertas M,Baslo MB

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Fast relief of migraine pain, associated symptoms, and migraine-related disability are priorities in the acute treatment of migraine. Efforts to improve the pharmacokinetic profiles of acute migraine treatments with the aim of providing faster relief include the development of non-oral routes of administrati...

journal_title：Headache

authors： Lipton RB,McGinley JS,Shulman KJ,Wirth RJ,Buse DC

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Though symptomatic medication overuse is believed to play a major role in progression from episodic to chronic or transformed migraine (TM), population-based longitudinal data on these agents are limited. OBJECTIVES:To assess the role of specific classes of acute medications in the development of TM in epis...

journal_title：Headache

authors： Bigal ME,Serrano D,Buse D,Scher A,Stewart WF,Lipton RB

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of ubrogepant on patient-reported functional disability, satisfaction with study medication, and global impression of change. BACKGROUND:Ubrogepant is a small-molecule, oral calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine. In 2 phase ...

journal_title：Headache

authors： Dodick DW,Lipton RB,Ailani J,Halker Singh RB,Shewale AR,Zhao S,Trugman JM,Yu SY,Viswanathan HN

更新日期：2020-04-01 00:00:00

abstract：:Ischemic colitis has not been reported in association with naratriptan therapy. We describe the occurrence of ischemic colitis in a patient who was treated with abortive doses of naratriptan for migraine and was also taking long-term oral contraceptives. Concurrent use of naratriptan and oral contraceptives should pro...

journal_title：Headache

authors： Charles JA,Pullicino PM,Stoopack PM,Shroff Y

更新日期：2005-04-01 00:00:00

abstract：:Forty-six migraineurs and 69 age- and sex-matched controls referred for MRI scans of the brain were evaluated for the incidence of intracranial pathology. Axial long TR/short TE and long TR/long TE and sagittal short TR/short TE scans were performed in all patients. Enhancement with Gd-DTPA was performed in all contro...

journal_title：Headache

authors： Robbins L,Friedman H

更新日期：1992-11-01 00:00:00

abstract：:The responses in cervicogenic headache to four different agents have been studied. Nitroglycerin was given sublingually to 27 patients. Eighteen patients got more than 20% increase of their headache. Of those with any headache increase at all, 12 got bilateral and 12 unilateral pain. The typical late cluster headache ...

journal_title：Headache

authors： Bovim G,Sjaastad O

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans. BACKGROUND:The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HT...

journal_title：Headache

authors： Kim WK,Kim HS,Kim WJ,Lee KY,Park H,Kim CH,Kim SJ,Choi YC

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To compare, using a within-woman analysis, the severity, duration, and relapse of menstrual vs nonmenstrual episodes of migraine during treatment with usual migraine therapy. BACKGROUND:Studies comparing the clinical characteristics of menstrual and nonmenstrual migraine attacks have yielded conflicting resu...

journal_title：Headache

authors： MacGregor EA,Victor TW,Hu X,Xiang Q,Puenpatom RA,Chen W,Campbell JC

更新日期：2010-04-01 00:00:00