Abstract:
:This study was designed to elucidate the hemodynamic and energetic changes of testicles in experimental varicocele. Partial ligation of the left renal vein was performed in 10 Sprague-Dawley rats to induce dilatation of the internal spermatic vein, and sham operation was performed in the other 10 age-matched Sprague-Dawley rats used as controls. Blood pressure and rectal temperature were maintained at a constant level. Testicular blood flow was detected by laser Doppler flowmeter on the day before surgery and 4 weeks after surgery, respectively. Concentrations of various adenine nucleotides were determined by high-performance liquid chromatography (HPLC). We found a significant decrease from 10.2 +/- 1.5 to 7.4 +/- 1.8 mlLD/min/100 g (p < 0.005) in testicular blood flow after inducing varicocele in the rats. The energy charge of adenine nucleotides of the varicocele-bearing rats was 0.62 +/- 0.07 which was significantly lower than the 0.73 +/- 0.02 of the control group (p < 0.005). These observations have, thus, led us to propose the hypothesis that impaired spermatogenesis may result from defective energy metabolism in the varicocele-bearing testicles of rats.
journal_name
Eur Uroljournal_title
European urologyauthors
Hsu HS,Chang LS,Chen MT,Wei YHdoi
10.1159/000475250subject
Has Abstractpub_date
1994-01-01 00:00:00pages
71-5issue
1eissn
0302-2838issn
1873-7560journal_volume
25pub_type
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