Disruption of the immunopeptidergic network in dietary migraine.

Abstract:

:This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.

journal_name

Headache

journal_title

Headache

authors

Martelletti P,Stirparo G,Rinaldi C,Frati L,Giacovazzo M

doi

10.1111/j.1526-4610.1993.hed3310524.x

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

524-7

issue

10

eissn

0017-8748

issn

1526-4610

journal_volume

33

pub_type

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