Activation and inactivation of human protein C by plasmin.

abstract：:The clinical impact of in-stent thrombosis is high because it is associated with high mortality and 20 % of the patients suffer a recurrent event within the two following years. The aim of this study was to characterise the morphologic and proteomic profile of in-stent thrombi (IST) in comparison to thrombi developed ...

journal_title：Thrombosis and haemostasis

authors： Cubedo J,Blasco A,Padro T,Ramaiola I,Juan-Babot O,Goicolea J,Fernández-Díaz JA,Oteo JF,Badimon L

更新日期：2017-08-30 00:00:00

abstract：:Platelet-leukocyte interactions are recognised to have pro-inflammatory effects, which may be important in the pathophysiology of ischaemic heart disease. Clopidogrel and the novel intravenous antithrombotic agent AR-C69931MX act at the level of the platelet P2Y12 receptor, which is known to amplify platelet activatio...

journal_title：Thrombosis and haemostasis

authors： Storey RF,Judge HM,Wilcox RG,Heptinstall S

更新日期：2002-09-01 00:00:00

abstract：:The ability of cellular fibronectin, found in the vessel wall in a fibrillar conformation, to regulate platelet functions and trigger thrombus formation remains largely unknown. In this study, we evaluated how parietal cellular fibronectin can modulate platelet responses under flow conditions. A fibrillar network was ...

journal_title：Thrombosis and haemostasis

authors： Maurer E,Schaff M,Receveur N,Bourdon C,Mercier L,Nieswandt B,Dubois C,Jandrot-Perrus M,Goetz JG,Lanza F,Gachet C,Mangin PH

更新日期：2015-11-25 00:00:00

abstract：:Compared to second generation, the use of third generation oral contraceptives has been associated with an increased risk of venous thrombosis especially in women with the factor V Leiden mutation. To find an explanation for these risk differences we investigated the effects of desogestrel- and levonorgestrel-containi...

journal_title：Thrombosis and haemostasis

authors： Kemmeren JM,Algra A,Meijers JC,Bouma BN,Grobbee DE

更新日期：2002-02-01 00:00:00

abstract：:The tail bleeding time (BT) in rats definitely varies according to the method applied. Of the various variables that may influence BT, we have evaluated the position (horizontal or vertical) of the tail, the environment (air or saline), the temperature (4 degrees, 23 degrees or 37 degrees C) and the type of anaesthesi...

journal_title：Thrombosis and haemostasis

authors： Dejana E,Villa S,de Gaetano G

更新日期：1982-08-24 00:00:00

abstract：:The release of microvesicles ('platelet microparticles', PMPs) by activated platelets has been shown to be an integral part of the thrombotic process. PMPs are believed to mediate many biological processes as they possess various platelet membrane proteins and bioactive lipids. Of note, there is a growing body of evid...

journal_title：Thrombosis and haemostasis

authors： Tan KT,Lip GY

更新日期：2005-09-01 00:00:00

abstract：:Platelet activation may contribute to the increased risk of thrombotic complications in patients with antiphospholipid antibodies (aPL). The increased urinary excretion of 11-dehydro-thromboxane B2 (11-DH-TXB2) reported in patients with lupus anticoagulant (LA) and/or anticardiolipin antibodies (aCL) reflects in vivo ...

journal_title：Thrombosis and haemostasis

authors： Forastiero R,Martinuzzo M,Carreras LO,Maclouf J

更新日期：1998-01-01 00:00:00

abstract：:Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in targe...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Ibrahim S,Lowe G,Moia M,Turpie AG,Roberts C,van den Besselaar AM,van der Meer FJ,Tripodi A,Palareti G,Shiach C,Bryan S,Samama M,Burgess-Wilson M,Heagerty A,Maccallum P,Wright D,Jespersen J,European

更新日期：2009-03-01 00:00:00

abstract：:We investigated the protective effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against two kinds of experimental disseminated intravascular coagulation (DIC) in rats. Endotoxin-induced experimental DIC was induced by a 4-h sustained infusion of endotoxin at a dose of 100 m...

journal_title：Thrombosis and haemostasis

authors： Yamazaki M,Asakura H,Aoshima K,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Ikeda T,Matsuda T

更新日期：1994-09-01 00:00:00

abstract：:This study was performed to assess the prevalence of deep vein thrombosis (DVT) in consecutive obstetric patients with clinical symptoms of DVT, using impedance plethysmography (IPG) as the diagnostic method and to establish the safety of withholding anticoagulant therapy in patients with a repeatedly normal IPG. In a...

journal_title：Thrombosis and haemostasis

authors： de Boer K,Büller HR,ten Cate JW,Levi M

更新日期：1992-01-23 00:00:00

abstract：:We studied the effect of purified immunoglobulins (Ig) from 21 patients with antiphospholipid antibodies (aPL) on factor Va degradation by activated protein C (aPC) on cultured human umbilical vein endothelial cells (HUVEC). Sera from patients were tested on an ELISA aPL assay to determine the isotype with aPL activit...

journal_title：Thrombosis and haemostasis

authors： Borrell M,Sala N,de Castellarnau C,Lopez S,Gari M,Fontcuberta J

更新日期：1992-09-07 00:00:00

abstract：:An experimental model incorporating cultured endothelial cells (EC) was used to study the "factor VIII bypassing" activity of prothrombin complex concentrates (PCC), a property exploited in the treatment of hemophiliacs with alloantibodies to factor VIII. Two PCC preparations were ineffective as stimuli of tissue fact...

journal_title：Thrombosis and haemostasis

authors： Teitel JM

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND: There have been no prior nationwide reports on the prevalence of hypertrophic cardiomyopathy (HCM) among patients suffering from atrial fibrillation (AF). It is also unclear how much stroke risk is attributable to HCM compared with other stroke risks in patients with AF. This study assessed the prevalence o...

journal_title：Thrombosis and haemostasis

authors： Jung H,Yang PS,Sung JH,Jang E,Yu HT,Kim TH,Uhm JS,Kim JY,Pak HN,Lee MH,Lip GYH,Joung B

更新日期：2019-02-01 00:00:00

abstract：:A complex of heparin and a quaternary ammonium compound dissolved in an organic solvent was investigated for its potential ability to prevent clotting on the surface of plastic catheters. Despite the complexing of heparin to ammonium, anticoagulant activity remained on in vitro testing. Both the heparin complex and it...

journal_title：Thrombosis and haemostasis

authors： Evans RW,Pasmantier MW,Coleman M,Wagner FS,Flair RC

更新日期：1979-05-25 00:00:00

abstract：:Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism. NOMAC/E2 is a new monophasic OC that combines nomegestrol acetate (NOMAC), a highly selective progestogen, with 17β-estradiol (E2). The study objective was to co...

journal_title：Thrombosis and haemostasis

authors： Gaussem P,Alhenc-Gelas M,Thomas JL,Bachelot-Loza C,Remones V,Ali FD,Aiach M,Scarabin PY

更新日期：2011-03-01 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:The structural determinants of lipopolysaccharide required for the induction of tissue factor in human umbilical vein endothelial cells were studied. Intact lipid A was essential for the induction of tissue factor whereas the incomplete lipid A precursors lipid IVA and lipid X, as well as monophosphoryl lipid A and ac...

journal_title：Thrombosis and haemostasis

authors： Moldow CF,Bach RR,Staskus K,Rick PD

更新日期：1993-10-18 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:Twenty-nine of 54 uremic patients had low levels of protein C measured as anticoagulant activity, contrasting with normal levels measured as amidolytic activity or antigenic concentration. We demonstrate that this discrepancy is due to the presence of a soluble plasma inhibitor that interferes specifically with the an...

journal_title：Thrombosis and haemostasis

authors： Faioni EM,Franchi F,Krachmalnicoff A,Valsecchi C,Viganò GL,Remuzzi G,Mannucci PM

更新日期：1991-10-01 00:00:00

abstract：:Tissue factor (TF) plays a pivotal role in thrombus formation and atherogenesis in acute coronary syndrome. Tissue factor pathway inhibitor (TFPI) is a specific physiological inhibitor of TF/FVIIa complex that regulates TF-induced coagulation. Adiponectin (Adp) is an adipocyte-specific adipocytokine with anti-atheroge...

journal_title：Thrombosis and haemostasis

authors： Chen YJ,Zhang LQ,Wang GP,Zeng H,Lü B,Shen XL,Jiang ZP,Chen FP

更新日期：2008-08-01 00:00:00

abstract：:The Bernard-Soulier syndrome (BSS) is characterized by thrombocytopenia with giant platelets, a prolonged bleeding time with defective platelet adhesion to the subendothelium related to a defect in platelet membrane glycoprotein Ib (GPIb) and a decreased prothrombin consumption. The mechanism of the latter abnormality...

journal_title：Thrombosis and haemostasis

authors： Bellucci S,Girma JP,Lozano M,Meyer D,Caen JP

更新日期：1997-02-01 00:00:00

abstract：:It has previously been reported that EGF enhances uPA but not tPA in the A431 squamous carcinoma cell line. To determine whether the absence of tPA modulation by EGF reflected steady levels or the action of an anti-activator, we assayed tPA, PAI-1 and tPA/PAI-1 complexes by zymography and immunological assays. Under c...

journal_title：Thrombosis and haemostasis

authors： George F,Pourreau-Schneider N,Arnoux D,Boutière B,Berthois Y,Martin PM,Sampol J

更新日期：1990-11-30 00:00:00

abstract：:Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM...

journal_title：Thrombosis and haemostasis

authors： Sobczak AIS,Phoenix FA,Pitt SJ,Ajjan RA,Stewart AJ

更新日期：2020-02-01 00:00:00

abstract：:Heparin therapy was monitored with the activated partial thromboplastin time (APTT) and with chromogenic substrate assays (factor Xa and factor IIa inhibition) in 100 plasma samples from 47 patients. Heparin concentrations were classified as being below, within or above a defined therapeutic range (TR; 0.2-0.55 units ...

journal_title：Thrombosis and haemostasis

authors： Fey MF,Lang M,Furlan M,Beck EA

更新日期：1987-10-28 00:00:00

abstract：:Primary immune thrombocytopaenia (ITP) is the most common haemorrhagic disease. Although most patients respond initially to mainstream therapies, such as corticosteroids, immunosuppressants or rituximab, a large proportion of patients fail to respond or relapse. These treatments only affect B lymphocytes or short-live...

journal_title：Thrombosis and haemostasis

authors： Li G,Wang S,Li N,Liu Y,Feng Q,Zuo X,Li X,Hou Y,Shao L,Ma C,Gao C,Hou M,Peng J

更新日期：2018-10-01 00:00:00

abstract：:Platelets are critically involved in atherosclerosis and acute thrombosis. The platelet phenotype shows a wide variability documented by the inherited difference of platelet reactivity, platelet volume and count and function of platelet surface receptors. Several candidate genes have been put into focus and investigat...

journal_title：Thrombosis and haemostasis

authors： Geisler T,Schaeffeler E,Gawaz M,Schwab M

更新日期：2013-11-01 00:00:00

abstract：:Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

journal_title：Thrombosis and haemostasis

authors： Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

更新日期：2005-06-01 00:00:00

abstract：:We previously reported a monoclonal antibody named IF-43 that specifically recognizes thrombin-modified fibrinogen (desAA- and desAABB- fibrin monomer) bound with fibrinogen or other D(1) domain-containing plasmic fragments such as fragments X,Y, and D(1), but not intact fibrinogen or cross-linked fibrin degradation p...

journal_title：Thrombosis and haemostasis

authors： Nakahara K,Kazahaya Y,Shintani Y,Yamazumi K,Eguchi Y,Koga S,Wada H,Matsuda M

更新日期：2003-05-01 00:00:00

abstract：:The in vitro effect of nifedipine, a calcium channel blocker of the dihydropyridine (DHP) type, on platelet aggregation was reinvestigated considering especially the capability of platelets to form endogenous nitric oxide (NO). We studied the dose-dependent antiaggregatory property of nifedipine in porcine platelet ri...

journal_title：Thrombosis and haemostasis

authors： Berkels R,Klaus W,Boller M,Rösen R

更新日期：1994-08-01 00:00:00

abstract：:The effect of a basic synthetic peptide, representing the C-terminal region of tissue factor pathway inhibitor (TFPI - Lys254 - Met276), as well as that of the whole protein, on the activity of lipoprotein lipase (LPL) is described. The activity of bovine LPL was measured by chromogenic assay using a water-soluble chr...

journal_title：Thrombosis and haemostasis

authors： Mukherjee M,Kakkar VV

更新日期：1999-12-01 00:00:00