Induction of endothelial tissue factor by endotoxin and its precursors.

abstract：:Three single nucleotide polymorphisms (-603A/G, -1322C/T, -1812C/T) and one deletion/insertion polymorphism (-1208D/I) are present in the tissue factor (TF) gene promoter sequence. These polymorphisms are in complete linkage disequilibrium, determining two haplotypes with almost equal frequency. The -603A/-1208D/-1322...

journal_title：Thrombosis and haemostasis

authors： Reny JL,Laurendeau I,Fontana P,Bièche I,Dupont A,Remones V,Emmerich J,Vidaud M,Aiach M,Gaussem P

更新日期：2004-02-01 00:00:00

abstract：:The interdependence of the predictive accuracy of serum osteoprotegerin (OPG) and von Willebrand factor (vWF) levels for long-term cardiovascular outcomes has not been investigated so far. This was a prospective observational cohort study in 361 patients with coronary artery disease undergoing percutaneous coronary in...

journal_title：Thrombosis and haemostasis

authors： Siller-Matula J,Lang IM,Schoergenhofer C,Roest M,Jilma B

更新日期：2017-08-30 00:00:00

abstract：:Tissue thromboplastin apoprotein was partially purified from human brain. The apoprotein was recombined with mixed phospholipids to yield active thromboplastin. The recombined thromboplastin induced proteolytic activation of isolated human factor IX in the presence of factor VII and Ca2+. The clotting times of various...

journal_title：Thrombosis and haemostasis

authors： van den Besselaar AM,Ram IE,Alderkamp GH,Bertina RM

更新日期：1982-08-24 00:00:00

abstract：:Factor VIII procoagulant activity (F VIII:C) and factor VIII related antigen (F VIII R: Ag) were investigated in 35 patients with Argentine hemorrhagic fever. Since the results obtained in the three clinical forms of the disease were not significantly different, they were tabulated altogether. F VIII:C was low in earl...

journal_title：Thrombosis and haemostasis

authors： Molinas FC,Maiztegui JI

更新日期：1981-08-28 00:00:00

abstract：:One hundred patients were included in a randomized open trial to assess the systemic factor Xa (FXa) and thrombin inhibitory effect as well as the safety profile of low molecular weight heparin (LMWH) given subcutaneously in conjunction with streptokinase (SK) in patients with acute myocardial infarction (MI). The tre...

journal_title：Thrombosis and haemostasis

authors： Nilsen DW,Gøransson L,Larsen AI,Hetland O,Kierulf P

更新日期：1997-01-01 00:00:00

abstract：:The haemostatic system and the use of heparin during cardiopulmonary bypass (CPB) have been studied extensively in adults but not in children. Results from adult trials cannot be extrapolated to children because of age-dependent physiologic differences in haemostasis. We studied 22 consecutive paediatric patients who ...

journal_title：Thrombosis and haemostasis

authors： Chan AK,Leaker M,Burrows FA,Williams WG,Gruenwald CE,Whyte L,Adams M,Brooker LA,Adams H,Mitchell L,Andrew M

更新日期：1997-02-01 00:00:00

abstract：:The prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due to the suboptimal half-lives of the products commercially available and currently in use, e.g. recombinant factor IX (rFIX) and recombinant factor VIIa (rFVIIa...

journal_title：Thrombosis and haemostasis

authors： Metzner HJ,Pipe SW,Weimer T,Schulte S

更新日期：2013-11-01 00:00:00

abstract：:Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

更新日期：2020-11-01 00:00:00

abstract：:Recent clinical studies have shown that the interruption of platelet function appears to be effective for treatment of coronary occlusive diseases. For this purpose, a Fab fragment of humanized anti-platelet glycoprotein (GP) IIb/IIIa monoclonal antibody (YM 337) that exhibited an in vivo antithrombotic effect without...

journal_title：Thrombosis and haemostasis

authors： Kuwahara M,Sugimoto M,Tsuji S,Miyata S,Nishio K,Kaku S,Suzuki K,Kawasaki T,Yoshioka A

更新日期：1998-07-01 00:00:00

abstract：:Circulating endotoxin is elevated in sepsis and plays a role in endothelial dysfunction whereas antithrombin is decreased by virtue of its consumption during complex formation with clotting factors and by proteolytic degradation by granulocyte elastase. Dysfunction of endothelium results in enhanced leukocyte rolling ...

journal_title：Thrombosis and haemostasis

authors： Kaneider NC,Förster E,Mosheimer B,Sturn DH,Wiedermann CJ

更新日期：2003-12-01 00:00:00

abstract：:In proliferative retinopathies, like proliferative diabetic retinopathy and retinopathy of prematurity (ROP), the hypoxia response is sustained by the failure of the retina to revascularise its ischaemic areas. Non-resolving retina ischaemia/hypoxia results in upregulation of pro-angiogenic factors and pathologic neov...

journal_title：Thrombosis and haemostasis

authors： Economopoulou M,Avramovic N,Klotzsche-von Ameln A,Korovina I,Sprott D,Samus M,Gercken B,Troullinaki M,Grossklaus S,Funk RH,Li X,Imhof BA,Orlova VV,Chavakis T

更新日期：2015-11-25 00:00:00

abstract：:Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). In this study, we examined how changes in platelet function relate to changes in platelet coun...

journal_title：Thrombosis and haemostasis

authors： Zwifelhofer NMJ,Bercovitz RS,Cole R,Yan K,Simpson PM,Moroi A,Newman PJ,Niebler RA,Scott JP,Stuth EAD,Woods RK,Benson DW,Newman DK

更新日期：2020-01-01 00:00:00

abstract：:Platelet aggregation and fibrinogen binding in whole blood, induced either by ADP or by a 14 amino acid peptide mimicking an N-terminal region of the platelet thrombin receptor (TRP, thrombin receptor activating peptide), have been studied with blood from different species. Aggregation was assessed by counting the num...

journal_title：Thrombosis and haemostasis

authors： Cook NS,Zerwes HG,Tapparelli C,Powling M,Singh J,Metternich R,Hagenbach A

更新日期：1993-09-01 00:00:00

abstract：:The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003...

journal_title：Thrombosis and haemostasis

authors： Kenet G,Waldman D,Lubetsky A,Kornbrut N,Khalil A,Koren A,Wolach B,Fattal A,Kapelushnik J,Tamary H,Yacobovitch J,Raveh E,Revel-Vilk S,Toren A,Brenner B

更新日期：2004-10-01 00:00:00

abstract：:Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by their ability to bind coagulation factors VIII and Va in reconstructed systems. It can be supposed that PMPs can contribute to the development o...

journal_title：Thrombosis and haemostasis

authors： Sinauridze EI,Kireev DA,Popenko NY,Pichugin AV,Panteleev MA,Krymskaya OV,Ataullakhanov FI

更新日期：2007-03-01 00:00:00

abstract：:We studied exercise-induced changes in coagulation and fibrinolytic factors and activation products in different age categories. Thirty-eight sedentary males, divided in three age categories (cats I-III; 20-30, 35-45 and 50-60 y) were subjected to a standardized exercise test. Pre-exercise levels (cats I-III resp) of ...

journal_title：Thrombosis and haemostasis

authors： van den Burg PJ,Hospers JE,van Vliet M,Mosterd WL,Bouma BN,Huisveld IA

更新日期：1995-12-01 00:00:00

abstract：:Long noncoding ribonucleic acids (lncRNAs) have been defined as transcripts which are > 200 ribonucleotides in size and are not translated into protein. Recent work has shown that many lncRNAs do have specific molecular functions and biological effects, and are involved in a growing number of diseases, including ather...

journal_title：Thrombosis and haemostasis

authors： Holdt LM,Kohlmaier A,Teupser D

更新日期：2019-08-01 00:00:00

abstract：:Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal module...

journal_title：Thrombosis and haemostasis

authors： Mosher DF

更新日期：1995-07-01 00:00:00

abstract：:Compelling evidence suggests that the risk of pulmonary embolism (PE) and deep-vein thrombosis (DVT) persists after hospital discharge in acutely-ill medical patients. However, no studies consistently supported the routine use of extended-duration thromboprophylaxis (ET) in this setting. We performed a meta-analysis t...

journal_title：Thrombosis and haemostasis

authors： Dentali F,Mumoli N,Prisco D,Fontanella A,Di Minno MN

更新日期：2017-02-28 00:00:00

abstract：:In patients with myeloproliferative disorders (MPD) a group of related diseases of the bone marrow stem cell and recurrent haemorrhagic and/or thrombotic complications, the production of aggregating prostaglandins (PGs) may be normal or slightly reduced, while PGI2 production is normal. However, MPD platelet sensitivi...

journal_title：Thrombosis and haemostasis

authors： Cortelazzo S,Galli M,Castagna D,Viero P,de Gaetano G,Barbui T

更新日期：1988-02-25 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor of venous thromboembolism. The risk of recurrence in patients with hyperhomocysteinemia is unknown, and the optimal therapy for these patients after acute venous thromboembolism is uncertain. In a multicenter study, 264 patients with an objectively documented single episode of idi...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Stümpflen A,Hirschl M,Bialonczyk C,Herkner K,Stain M,Schneider B,Pabinger I,Lechner K,Kyrle PA

更新日期：1998-10-01 00:00:00

abstract：:Novel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothe...

journal_title：Thrombosis and haemostasis

authors： Koller L,Hohensinner P,Sulzgruber P,Blum S,Maurer G,Wojta J,Hülsmann M,Niessner A

更新日期：2016-08-01 00:00:00

abstract：:The novel fast inhibitor to tissue plasminogen activator in plasma has been determined in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis or previous history of thrombosis, diabetes and others). In hea...

journal_title：Thrombosis and haemostasis

authors： Wiman B,Csemiczky G,Marsk L,Robbe H

更新日期：1984-10-31 00:00:00

abstract：:Autoantibodies to the zwitterionic phospholipid (PL), phosphatidylethanolamine (PE) have been described in patients with thrombotic diseases. Recently, we reported that many antiphosphatidylethanolamine antibodies (aPE) are not specific for PE per se, but are directed to plasma proteins which can bind PE, for example,...

journal_title：Thrombosis and haemostasis

authors： Sugi T,Mclntyre JA

更新日期：1996-09-01 00:00:00

abstract：:DX-9065a is an antithrombin III (AT III)-independent and selective inhibitor of activated blood coagulation factor X (FXa). We evaluated the effects of DX-9065a and warfarin on bleeding time and blood loss in rat tail transection model and on blood loss in hydrochloride (HCl)-induced rat gastrointestinal haemorrhage m...

journal_title：Thrombosis and haemostasis

authors： Tanabe K,Morishima Y,Shibutani T,Terada Y,Hara T,Shinohara Y,Aoyagi K,Kunitada S,Kondo T

更新日期：1999-05-01 00:00:00

abstract：:Desmopressin acetate administration markedly stimulates release of tissue plasminogen activator (t-PA) from vascular endothelial cells. The mechanism for this effect is unknown. Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA re...

journal_title：Thrombosis and haemostasis

authors： Grant MB,Guay C,Lottenberg R

更新日期：1988-04-08 00:00:00

abstract：:It was the study objective to evaluate whether chewing a 180 mg loading dose of ticagrelor versus an equal dose of traditional oral administration, enhances inhibition of platelet aggregation 1 hour (h) after administering a ticagrelor loading dose in non-ST elevation myocardial infarction (NSTEMI) patients. Dual anti...

journal_title：Thrombosis and haemostasis

authors： Asher E,Frydman S,Katz M,Regev E,Sabbag A,Mazin I,Abu-Much A,Kukuy A,Mazo A,Erez A,Berkovitch A,Narodistky M,Barbash I,Segev A,Beigel R,Matetzky S

更新日期：2017-04-03 00:00:00

abstract：:Genetic determinants of venous thromboembolism (VTE) in the African-American population are poorly characterised. It was recently shown that fibrinogen gamma gene (FGG) polymorphisms 10034C>T and 9340T>C influence VTE risk in the Caucasian population. In the African-American population these polymorphisms are common, ...

journal_title：Thrombosis and haemostasis

authors： Uitte de Willige S,Pyle ME,Vos HL,de Visser MC,Lally C,Dowling NF,Hooper WC,Bertina RM,Austin H

更新日期：2009-06-01 00:00:00

abstract：:Subcutaneous heparin is the treatment of choice for women requiring anticoagulant therapy during pregnancy. However, heparin therapy presents a management problem at delivery because of its potential to cause a persistent anticoagulant effect and thus increase the risk of bleeding. In order to avoid therapeutic compli...

journal_title：Thrombosis and haemostasis

authors： Anderson DR,Ginsberg JS,Burrows R,Brill-Edwards P

更新日期：1991-03-04 00:00:00

abstract：:In order to assess the value of I.P.G. for the diagnosis of D.V.T. in general practice, an I.P.G. was carried out by a skilled technician in 255 consecutive patients with suspected D.V.T. at home. Ascending venography was carried out in 185 of these patients. In addition, blood for assay of AT III, platelet count, fib...

journal_title：Thrombosis and haemostasis

authors： Peters SH,Jonker JJ,de Boer AC,den Ottolander GJ

更新日期：1982-12-27 00:00:00