当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat.

Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat.

Abstract：

:The effects on the hippocampal electroencephalogram of microinjections of procaine hydrochloride and the serotonin1A agonists, 8-OH-DPAT and buspirone, into the median raphe nucleus were examined in the urethane anesthetized rat. Injections of procaine, 8-OH-DPAT or buspirone into the median raphe nucleus produced a change in the hippocampal electroencephalogram from a spontaneous desynchronized pattern to a synchronized pattern (theta rhythm) within short latencies and for long durations post-injection. Procaine was shown to elicit theta at a mean latency of 52 s and for a mean duration of 21.75 min; buspirone at a mean latency of 2 min and for a mean duration of 34.5 min. A dose dependent relationship was observed between 8-OH-DPAT injections and latencies but not durations. Small doses (0.5 micrograms) of 8-OH-DPAT produced theta at a mean latency of 1.33 min and large doses (3.0 micrograms) at a mean latency of 1.17 min. 8-OH-DPAT injections generated theta for a mean duration of 62 min. Injections of each of these substances into structures dorsal, lateral or rostrocaudal to the median raphe (dorsal raphe nucleus, pontine reticular formation, caudal linear nucleus or raphe pontis, respectively) failed to generate theta or in a few cases produced theta at very long latencies (> 24 min). Saline injections in the median raphe nucleus or control structures were without effect. The demonstration that agents injected into the median raphe nucleus that inhibit its activity (procaine and serotonin1A agonists) produce theta indicate that serotonin-containing median raphe neurons normally suppress theta or are involved in the control of hippocampal desynchronization. The present findings are consistent with previous work showing that median raphe nucleus stimulation desynchronizes the hippocampal electroencephalogram and that median raphe nucleus lesions produce constant theta, but are at odds with the proposal that serotonergic mechanisms may play a role in the generation of the theta rhythm.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Vertes RP,Kinney GG,Kocsis B,Fortin WJ

doi

10.1016/0306-4522(94)90255-0

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

441-51

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(94)90255-0

journal_volume

60

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Gonadal hormone regulation of the emotion circuitry in humans.

    abstract：:Gonadal hormones are known to influence the regulation of emotional responses and affective states. Whereas fluctuations in progesterone and estradiol are associated with increased vulnerability for mood disorders, testosterone is mainly associated with social dominance, aggressive, and antisocial behavior. Here, we r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.04.042

    authors： van Wingen GA,Ossewaarde L,Bäckström T,Hermans EJ,Fernández G

    更新日期：2011-09-15 00:00:00

  • Enkephalin-like immunoreactivity within the telencephalon of the reptile Caiman crocodilus.

    abstract：:Immunohistochemical methods were used to characterize the distribution of staining for leucine enkephalin-like and methionine enkephalin-like immunoreactivities in the telencephalon of Caiman crocodilus. Very similar distributions of both leucine enkephalin-like and methionine enkephalin-like immunoreactivity were obs...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90028-9

    authors： Brauth SE

    更新日期：1984-02-01 00:00:00

  • Muscle stiffness and continuous electromyographic activity in old rats; an animal model for spasticity?

    abstract：:A mechanomyographic response of the hind foot to passive straightening and bending, as well as an electromyographic activity of the gastrocnemius and tibialis anterior muscles were recorded in old (35-44-month-old) and young female rats. In old rats, spontaneous, tonic electromyographic activity patterns were concurre...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90481-g

    authors： Ossowska K,Schulze G,Wolfarth S,Coper H,Kaminska A,Hausmanowa-Petrusewicz I

    更新日期：1992-11-01 00:00:00

  • [D-Pen2,D-Pen5]enkephalin, a delta opioid agonist reduces endogenous aluminum content in the rat central nervous system.

    abstract：:The in vivo effects of [D-Pen2,D-Pen5]enkephalin, a cyclic peptide agonist with high affinity and selectivity for the delta opioid receptors, on the endogenous aluminum content of selected areas of rat brain and spinal cord were studied by means of atomic absorption spectrophotometry. Intracerebroventricular injection...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)00575-p

    authors： Gulya K,Szikra J,Kása P

    更新日期：1995-05-01 00:00:00

  • Importance of D1 and D2 receptors in the dorsal caudate-putamen for the locomotor activity and stereotyped behaviors of preweanling rats.

    abstract：:Dopaminergic compounds often affect the unlearned behaviors of preweanling and adult rats differently, although the brain regions underlying these age-dependent behavioral effects have not been specified. A candidate brain region is the dorsal caudate-putamen (CPu); thus, a goal of the present study was to determine w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.03.037

    authors： Charntikov S,Der-Ghazarian T,Herbert MS,Horn LR,Widarma CB,Gutierrez A,Varela FA,McDougall SA

    更新日期：2011-06-02 00:00:00

  • Form of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hippocampal progenitors, and some cholinergic axon terminals.

    abstract：:Compelling lines of evidence indicate that overexpression of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) in subjects with trisomy 21 (Down syndrome[DS]) contributes to the abnormal structure and function of the DS brain. In the present study, we used a novel, phospho-dependent antibody r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.08.028

    authors： Kida E,Walus M,Jarząbek K,Palminiello S,Albertini G,Rabe A,Hwang YW,Golabek AA

    更新日期：2011-11-10 00:00:00

  • Recovery of whisking function after manual stimulation of denervated vibrissal muscles requires brain-derived neurotrophic factor and its receptor tyrosine kinase B.

    abstract：:Functional recovery following facial nerve injury is poor. Neuromuscular junctions (NMJs) are "bridged" by terminal Schwann cells and numerous regenerating axonal sprouts. We have shown that this poly-innervation of NMJs can be reduced by manual stimulation (MS) with restoration of whisking function. In addition, we h...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.06.053

    authors： Söhnchen J,Grosheva M,Kiryakova S,Hübbers CU,Sinis N,Skouras E,Ankerne J,Kaidoglou K,Fries JW,Irintchev A,Dunlop SA,Angelov DN

    更新日期：2010-09-29 00:00:00

  • Functional glutamatergic and glycinergic inputs to several superior olivary nuclei of the rat revealed by optical imaging.

    abstract：:Superior olivary complex (SOC) neurons receive excitatory and inhibitory inputs from both ears. We determined the nature of such inputs to the main SOC nuclei with an optical imaging system. To do so, brainstem slices of postnatal (P) rats (P3-13) were treated with the fast voltage-sensitive dye RH795, and ipsilateral...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.06.012

    authors： Srinivasan G,Friauf E,Löhrke S

    更新日期：2004-01-01 00:00:00

  • 1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport.

    abstract：:Alzheimer's disease (AD) is characterized by the accumulation and deposition of plaques of amyloid-β (Aβ) peptide in the brain. Growing epidemiological and experimental studies have shown that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) exerts neuroprotection against AD. However, the underlying mechanisms of the action rem...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.01.041

    authors： Guo YX,He LY,Zhang M,Wang F,Liu F,Peng WX

    更新日期：2016-05-13 00:00:00

  • Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF-NMDAR pathways in a rat model of vascular dementia.

    abstract：:This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze the associated mechanisms. Bilateral carotid artery occlusion (2-VO) was used to establish a rat model of VaD. High-frequency (5Hz) rTMS was pe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.10.038

    authors： Zhang N,Xing M,Wang Y,Tao H,Cheng Y

    更新日期：2015-12-17 00:00:00

  • Endogenous Expectations for Sequence Continuation after Auditory Beat Accelerations and Decelerations Revealed by P3a and Induced Beta-Band Responses.

    abstract：:People commonly synchronize taps to rhythmic sounds and can continue tapping after the sounds stop, indicating that time intervals between sounds can be internalized. Here, we investigate what happens in the brain after simply listening to auditory beats in order to understand more about the automatic internalization ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.06.010

    authors： Graber E,Fujioka T

    更新日期：2019-08-10 00:00:00

  • Genetic Inactivation of Cholinergic C Bouton Output Improves Motor Performance but not Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.

    abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.07.047

    authors： Konsolaki E,Koropouli E,Tsape E,Pothakos K,Zagoraiou L

    更新日期：2020-12-01 00:00:00

  • Moderate hypoglycemia aggravates effects of hypoxia in hippocampal slices from diabetic rats.

    abstract：:We recorded the effects of hypoxia combined with relative hypoglycemia on pre- and post-synaptic potentials in the CA1 area of slices from 4-month-old control and diabetic (streptozotocin-treated) Wistar rats. In experiments on slices kept in 10 or 4 mM glucose (at 33 degrees C), hypoxia was applied until the pre-syna...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00154-9

    authors： Tekkök SB,Godfraind JM,Krnjević K

    更新日期：2002-01-01 00:00:00

  • Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.

    abstract：:Adenosine has been proposed as a homeostatic "sleep factor" that promotes the transition from waking to sleep by affecting several sleep-wake regulatory systems. In the basal forebrain, adenosine accumulates during wakefulness and, when locally applied, suppresses neuronal activity and promotes sleep. However, the neu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.010

    authors： Arrigoni E,Chamberlin NL,Saper CB,McCarley RW

    更新日期：2006-06-30 00:00:00

  • Lesions to the basolateral amygdala and the orbitofrontal cortex but not to the medial prefrontal cortex produce an abnormally persistent latent inhibition in rats.

    abstract：:Repeated nonreinforced preexposure to a stimulus interferes with the establishment of conditioned responding to this stimulus when it is subsequently paired with reinforcement. This stimulus-preexposure effect is known as latent inhibition (LI). Rather remarkably, LI appears to be resistant to the effects of numerous ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.06.020

    authors： Schiller D,Weiner I

    更新日期：2004-01-01 00:00:00

  • Plasmalemmal appositions between cholinergic and non-cholinergic neurons in rat caudate-putamen nuclei.

    abstract：:We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90341-k

    authors： Pickel VM,Chan J

    更新日期：1991-01-01 00:00:00

  • A physiological role for nitric oxide in the centrally mediated sympathetic and somatomotor ejaculatory response in anesthetized male Wistar rats.

    abstract：:Neurones in the lumbosacral spinal cord are known to play a significant role in ejaculation. In these same areas neurones containing nitric oxide synthase (NOS) have been described. This raised the question as to whether there is a physiological role for nitrous oxide (NO) in the spinal cord in sexual behavior. We fir...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.09.010

    authors： Brack KE,Watkins N,Pyner S,Coote JH

    更新日期：2007-12-05 00:00:00

  • Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.

    abstract：BACKGROUND:Spasticity and rigidity are serious complications associated with spinal traumatic or ischemic injury. Clinical studies show that tizanidine (Tiz) is an effective antispasticity agent; however, the mechanism of this effect is still not clear. Tiz binds not only to α2-adrenoreceptors (AR) but also to imidazol...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.08.022

    authors： Fuchigami T,Kakinohana O,Hefferan MP,Lukacova N,Marsala S,Platoshyn O,Sugahara K,Yaksh TL,Marsala M

    更新日期：2011-10-27 00:00:00

  • Adversity in early adolescence promotes an enduring anxious phenotype and increases serotonergic innervation of the infralimbic medial prefrontal cortex.

    abstract：:Stress during early development produces lasting effects on psychopathological outcomes. We analysed the impact of prior intermittent, physical stress (IPS) during early adolescence (PD 22-33) on anxiety-like behaviour of female rats in adulthood. After behavioural testing, we used immunohistochemistry for the 5-HT tr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.09.004

    authors： Tao CS,Dhamija P,Booij L,Menard JL

    更新日期：2017-11-19 00:00:00

  • Ontogenesis of tyrosine hydroxylase-immunopositive structures in the rat hypothalamus. An atlas of neuronal cell bodies.

    abstract：:The development of the catecholaminergic system in the hypothalamus and in the septal region was studied in rats from the 12th fetal day until the 9th postnatal day. Catecholaminergic structures were visualized with pre-embedding immunocytochemistry using antiserum to tyrosine hydroxylase. An intensification of diamin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90338-2

    authors： Ugrumov MV,Taxi J,Tixier-Vidal A,Thibault J,Mitskevich MS

    更新日期：1989-01-01 00:00:00

  • Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats.

    abstract：:Central blockade of mineralocorticoid receptors (MRs) or angiotensin II type 1 receptors (AT1Rs) attenuates aldosterone (aldo)-salt induced hypertension. We examined the role of the subfornical organ (SFO), aldo synthesized locally in the brain, and MR and AT1R specifically in the paraventricular nucleus (PVN) in aldo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.11.055

    authors： Wang HW,Huang BS,Chen A,Ahmad M,White RA,Leenen FH

    更新日期：2016-02-09 00:00:00

  • Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception.

    abstract：:In genetically-modified Lmx1b(f/f/p) mice, selective deletion of LMX1B in Pet-1 expressing cells leads to failure of embryonic development of serotonin (5-HT) neurons. As adults, these mice have a decreased hypercapnic ventilatory response and abnormal thermoregulation. This mouse model has been valuable in defining t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.08.018

    authors： Cerpa V,Gonzalez A,Richerson GB

    更新日期：2014-10-24 00:00:00

  • Co-localization of tyrosine hydroxylase and zebrin II immunoreactivities in Purkinje cells of the mutant mice, tottering and tottering/leaner.

    abstract：:The mutant mice tottering, leaner and the compound heterozygous tottering/leaner exhibit varying degrees of several abnormal neurological phenotypes including petit mal-like epilepsy, ataxia and an intermittent myoclonus-like movement disorder. Aberrant expression of tyrosine hydroxylase in cerebellar Purkinje cells o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00444-0

    authors： Abbott LC,Isaacs KR,Heckroth JA

    更新日期：1996-03-01 00:00:00

  • Computational physiology of the neural networks of the primate globus pallidus: function and dysfunction.

    abstract：:The dorsal pallidal complex is made up of the external and internal segments of the globus pallidus (GPe and GPi respectively). It is part of the main axis of the basal ganglia (BG) that connects the thalamo-cortical networks to the BG input stages (striatum and subthalamic nucleus) and continues directly, and indirec...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2011.08.068

    authors： Goldberg JA,Bergman H

    更新日期：2011-12-15 00:00:00

  • Transient lesion-induced increase of basic fibroblast growth factor and its receptor in layer VIb (subplate cells) of the adult rat cerebral cortex.

    abstract：:Basic fibroblast growth factor is a potent trophic factor with a wide spectrum of activity at various stages of neuronal development. In our studies on the effects of select lesions on the expression of growth factors, we observed that neurons of layer VIb of the rat cerebral cortex developed immunoreactivity for basi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90355-6

    authors： Gómez-Pinilla F,Cotman CW

    更新日期：1992-08-01 00:00:00

  • Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord.

    abstract：:In the spinal cord, glycine and γ-amino butyric acid (GABA) are inhibitory neurotransmitters. However, the ontogeny of the glycinergic network remains unclear. To address this point, we examined the developmental formation of glycinergic terminals by immunohistochemistry for glycine transporter 2 (GlyT2), a marker of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.12.032

    authors： Sunagawa M,Shimizu-Okabe C,Kim J,Kobayashi S,Kosaka Y,Yanagawa Y,Matsushita M,Okabe A,Takayama C

    更新日期：2017-02-20 00:00:00

  • Expression of thymosin beta4 messenger RNA in normal and kainate-treated rat forebrain.

    abstract：:Thymosin beta4 is a major actin-sequestering peptide widely distributed in mammalian tissues, including the nervous system. In the present study, we analyse the expression of thymosin beta4 in normal and kainate-treated rat forebrain. In untreated animals, thymosin beta4 messenger RNA is mainly expressed in neurons of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00494-1

    authors： Carpintero P,Anadón R,Díaz-Regueira S,Gómez-Márquez J

    更新日期：1999-01-01 00:00:00

  • Sciatic nerve conditioned medium depleted of pro-NGF modulates sodium currents and neurite outgrowth in PC12 cells.

    abstract：:Excitability and axon/dendrite specification are the most distinctive features in the establishment of neuronal polarization. Conditioned medium from rat sciatic nerve (CM) induced a neuronal-like morphology in PC12 cells. Here we show that CM neuritogenic activity is limited to the induction of dendrites in PC12 cell...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.12.063

    authors： Longart M,García L,Castillo C,Martínez JC,Medina R,Forsyth P,Malavé C

    更新日期：2009-03-17 00:00:00

  • Complex influence of the L-type calcium-channel agonist BayK8644(+/-) on N-methyl-D-aspartate responses and neuronal survival.

    abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00312-1

    authors： Barger SW

    更新日期：1999-03-01 00:00:00

  • Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity.

    abstract：:We examined the organization of spinal networks controlling locomotion in the isolated spinal cord of the neonatal rat, and in this study we provide the first demonstration of plateau and bursting mechanisms in mammalian interneurons that show locomotor-related activity. Using tight-seal whole-cell recordings, we char...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00250-3

    authors： Kiehn O,Johnson BR,Raastad M

    更新日期：1996-11-01 00:00:00