Abstract：
:In 44 subjects (healthy controls and patients with allergic, non-allergic or infectious rhinitis) we compared nasal histamine and methacholine responsiveness. A weak correlation between histamine- and methacholine-induced secretion was found (r = 0.34; p = 0.02), in contrast to the highly significant association between secretion and sneezes induced by histamine (r = 0.78; p < 0.0001). Our observations suggest that histamine and methacholine responsiveness represent different forms of upper airway hyperreactivity. The contribution of glandular responsiveness as measured by methacholine challenge and the involvement of irritant receptors or reflexes as measured by histamine provocation may vary between individuals.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Gerth van Wijk R,Dieges PHsubject
Has Abstractpub_date
1994-09-01 00:00:00pages
119-22issue
3eissn
0300-0729issn
1996-8604journal_volume
32pub_type
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