Abstract：
BACKGROUND:Aim of this study was to investigate whether intranasal anatomy plays a role in intranasal trigeminal sensitivity. MATERIAL AND METHODS:A total of 65 healthy subjects (30 female, 35 male) participated in this study (age range 18-35 years). Nasal cavities were assessed using magnetic resonance imaging (MRI). The area of the nasal cavity was measured in 5 coronal sections distributed across the length of the nasal cavity. Trigeminal function was assessed by determining thresholds for CO2, and responses to suprathreshold stimulation with CO2 and menthol (intensity ratings; event-related potentials). In addition, rhino-manometric measures were obtained. RESULTS:A positive correlation was found between the size of the nasal cavity and trigeminal event-related potentials in response to suprathreshold CO2 and menthol stimuli. By contrast, no such correlations were found between nasal cavity size and CO2 thresholds. Results from rhino-manometry correlated only with the size of the nasal cavity in the nasal valve area. CONCLUSIONS:These data suggest that, at least at a suprathreshold level, nasal anatomy plays a significant role in determining interindividual differences in the sensitivity to trigeminal stimuli.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Konstantinidis I,Gartz I,Gerber JC,Reden J,Hummel Tdoi
10.4193/Rhin09.060subject
Has Abstractpub_date
2010-03-01 00:00:00pages
18-22issue
1eissn
0300-0729issn
1996-8604pii
09.060journal_volume
48pub_type
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