Abstract：
BACKGROUND:Chronic eosinophilic rhinosinusitis with nasal polyps (CRSwNP eosinophilic) is characterised by the formation of benign and bilateral nasal polyps. We aimed to compare the effectiveness of azithromycin as an immunomodulator with the use of a placebo in patients presenting with CRSwNP concomitant with asthma and aspirin intolerance after 3 months of treatment and at a 1-year follow-up. METHODOLOGY:We performed a randomised, double-blind, placebo-controlled trial. Patients received 500 mg azithromycin orally three times/week for 12 weeks. Improvement was evaluated by staging, the Sino-Nasal Outcome Test (SNOT-22), and nasal polyp biopsy. Data collected at pretreatment and 3 months posttreatment were compared. Quality of life was evaluated at the 1-year follow-up. RESULTS:Twenty-seven and 21 patients were treated with azithromycin and a placebo, respectively. The medication was well tolerated overall. Twenty patients (74%) in the azithromycin group and three patients (14%) in the placebo group were not refer- red for surgery at the end of the 3-month treatment. Regarding subjective improvement, there was a median decrease only in the azithromycin group, and the between-group difference was significant. SNOT-22 improvement was maintained in the azithromy- cin group at the 1-year follow-up. CONCLUSIONS:Azithromycin could be considered a therapeutic option for patients presenting with CRSwNP concomitant with asthma and aspirin intolerance.
journal_name
Rhinologyjournal_title
Rhinologyauthors
de Oliveira IS,Guimaraes AF,Arantes Pêgas GF,Machado CJ,Cassali GD,Crosara PFTB,Barbosa Nunes F,Gonçalves Becker HM,Santos Guimarães RE,Tormin Borges Crosara PFdoi
10.4193/Rhin20.071subject
Has Abstractpub_date
2020-12-01 00:00:00pages
610-617issue
6eissn
0300-0729issn
1996-8604pii
2662journal_volume
58pub_type
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