Abstract：
STATEMENT OF PROBLEM:Inverted papilloma (IP) is a proliferative lesion of the epithelium lining the sinonasal tract, characterized by marked propensity for recurrence and association with carcinoma. To determine a putative role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in the establishment of IP, their expression was studied in IP. METHODS:Archived surgical specimens from 15 IPs were studied using immunohistochemistry and compared to 12 nasal polyps (NP), a model of chronic respiratory mucosal inflammation, and to 6 control nasal mucosa (CM) samples obtained from snorers during turbinectomy. Within IP, MMP-2 and -9 expression was compared between tumoral areas with hyperplastic epithelium and non tumoral areas with nonhyperplastic epithelium. RESULTS:In IP, MMP-2 and MMP-9 epithelial expression was not different compared to CM and NP. MMP-9 expression in submucosal inflammatory cells was not different between IP and CM or NP. However, within IP, a significantly increased number of MMP-9 positive inflammatory cells in the lamina propria adjacent to the hyperplastic epithelium was observed compared to the lamina propria adjacent to nonhyperplastic epithelium. CONCLUSION:Our findings suggest that MMP 9 expressing inflammatory cells may be involved in the pathophysiology of IP.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Papon JF,Lechapt-Zalcman E,Abina M,Abd-al-Sama I,Peynègre R,Escudier E,Coste Asubject
Has Abstractpub_date
2006-09-01 00:00:00pages
211-5issue
3eissn
0300-0729issn
1996-8604journal_volume
44pub_type
杂志文章相关文献
RHINOLOGY文献大全abstract：BACKGROUND:The role of tranexamic acid in patients undergoing endoscopic sinus surgery (ESS) is not clearly defined. The aim of our study is to systematically review the existing evidence on the role of tranexamic acid in patients undergoing ESS. METHODOLOGY:Systematic search of MEDLINE (1950 - 2013), EMBASE (1980 - 2...
journal_title：Rhinology
pub_type： 杂志文章,meta分析,评审
doi：10.4193/Rhin13.042
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Monoclonal antibodies have been proposed as a novel therapy in patients suffering from chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this systematic review was to evaluate their efficacy and safety. METHODOLOGY:A literature search was performed in MEDLINE, Web of Science, the Cochrane...
journal_title：Rhinology
pub_type： 杂志文章,评审
doi：10.4193/Rhin17.156
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVES:To evaluate the anatomic variations of neurovascular structures adjacent to the sphenoid sinus and their agreement between right and left sides as well as differences between sexes. METHODS:Forty-five cadavers were dissected (24 men, and differences between sexes and agreement of anatomic variations of the ...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Chronic eosinophilic rhinosinusitis with nasal polyps (CRSwNP eosinophilic) is characterised by the formation of benign and bilateral nasal polyps. We aimed to compare the effectiveness of azithromycin as an immunomodulator with the use of a placebo in patients presenting with CRSwNP concomitant with asthma ...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin20.071
更新日期：2020-12-01 00:00:00
abstract：:Electroencephalographic techniques are widely used to provide an objective evaluation of the chemosensory function and to explore neural mechanisms related to the processing of chemosensory events. The most popular technique to evaluate brain responses to chemosensory stimuli is across trial time-domain averaging to r...
journal_title：Rhinology
pub_type： 杂志文章,评审
doi：10.4193/Rhino11.126
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Nasal polyposis (NP) is an inflammatory disease of the upper nasal airways frequently present in CF patients. Interferon-Related Developmental Regulator 1 (IFRD1) gene was reported as a possible modifier of CF lung disease severity. Three IFRD1 SNPs were analyzed to investigate a possible effect on the devel...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin14.229
更新日期：2015-12-01 00:00:00
abstract：:Several recent studies have indicated that the paranasal sinus bones undergo pathophysiological changes in patients with chronic sinusitis. We examined the mineralization activity of osteoblasts and the production of osteocalcin and cytokines in cultured human osteoblasts derived from ethmoidal bones treated with vita...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:Residual sleepiness after continuous positive airway pressure (CPAP) is a critical problem in some patients with obstructive sleep apnea syndrome (OSAS). However, nasal surgery is likely to reduce daytime sleepiness and feelings of unrefreshed sleep. The aim of this study is to clarify the effects of nasal su...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin17.026
更新日期：2017-09-01 00:00:00
abstract：:The tissue blood flow of the nasal mucosa in normal subjects and patients with nasal allergy was studied by the hydrogen clearance method. The flow in the inferior turbinate in normal subjects and patients with nasal allergy did not differ. The test results were highly reproducible and were almost the same in differen...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：OBJECTIVES:During endoscopic surgery, it is difficult to ascertain the anatomical landmarks once the anatomy is fiddled with or if the operating area is filled with blood. An augmented reality system will enhance the endoscopic view and further enable surgeons to view hidden critical structures or the results of preope...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：:Patients requiring home oxygen can experience drying and crusting of nasal mucosa. On occasion it can be severe causing significant discomfort. In this report we present such a case. To prevent nasal airflow and hence reduce symptoms the patient was fitted with a nasal obturator. The use of the nasal obturator resulte...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：AIM:Parosmia can be defined as a qualitative odor distortion. Despite the consequences of this condition for quality of life, the scientific literature lacks information about the prevalence of parosmia in the general population, which was the objective of the present study. METHODS:Random samples of 1,900 adult and 4...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：:A group of 51 patients was studied by a technique of active posterior rhinomanometry that assessed the influence of breath holding, hyperventilation, and exercise on nasal resistance. Breath hodling of 30 seconds or longer produced a decrease in nasal resistance in most of the subjects tested. Hyperventilation had var...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1978-12-01 00:00:00
abstract：:Nasal airflow resistances were measured simultaneously by face mask and "head-out" body plethysmograph and compared. Computer averaging of transnasal pressure and flow signals digitized at 50Hz during 5 breath sequences was employed to determine a ratio of pressure to flow as an index of nasal resistance to breathing....
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:Empirical antibiotics constitute the cornerstone of medical therapy for chronic sinusitis due to difficulties of obtaining cultures from the paranasal sinuses. Indirect isolation of the pathogenic microorganisms outside the paranasal sinuses with a non-invasive method may enable administration of specific antibiotics....
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:A rare case--only the fourth as known--of a nasal schwannoma with intracranial extension is presented. A 28-year-old Japanese man complained of right nasal obstruction and bleeding for one year. A biopsy indicated the presence of a nasal schwannoma. Computed tomography and magnetic resonance imaging demonstrated intra...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:Nasal septal abscess is an uncommon condition. Most commonly it is secondary to nasal trauma, which leads to haematoma, and subsequent abscess formation. There are other less common causes like sinusitis, dental infections and furunculosis. Non-traumatic nasal septal abscess has also been reported in immunocompromised...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhino08.142
更新日期：2009-12-01 00:00:00
abstract：:The site of origin of sino-nasal polyps was documented in 113 consecutive patients undergoing functional endoscopic sinus surgery (FESS). These patients were assigned pre-operatively to 4 clinical groups according to the out-patient recorded endoscopic appearance of their nasal cavities; chronic rhinosinusitis without...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Anatomical studies of the rabbit paranasal cavities are impelled by the increasing interest in the rabbit model to investigate human sinusitis. Although several such studies have already been performed, the topography of the rabbit dorsal conchal and maxillary sinuses is described ambiguously and the existen...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin09.193
更新日期：2010-09-01 00:00:00
abstract：:The author, in an attempt to define the most suitable means for the preclinical diagnosis of allergic rhinopathy, submitted 1620 pupils from seven different state schools to examination. Their parents were asked to fill in a questionnaire through which 370 were considered to be "at risk". All children underwent scratc...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：AIM:Evaluation of the side-effects of conventional subcutaneous allergen immunotherapy in inhalant allergy. MATERIAL AND METHODS:Retrospective analysis of early and late, local and systemic, short-term and long-term side-effects of 4723 injections given to 224 patients suffering from intermittent or persistent allergi...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2007-06-01 00:00:00
abstract：AIM:Obstruction of the osteomeatal complex is the commonest anatomic finding in revision endoscopic sinus surgery. This study assesses the efficacy of topical mitomycin C in the middle meatus, intra- and postoperatively in the prevention of adhesion formation and restenosis of the maxillary sinus antrostomy. MATERIALS...
journal_title：Rhinology
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-06-01 00:00:00
abstract：:During 4 weeks of the grass pollen season in the south of Sweden 27 patients with seasonal allergic rhinitis were treated topically with a beta-adrenoceptor stimulant, KWD 2131, which in an earlier rhinomanometric study had shown a prophylactic effect at nasal allergen provocations in hay-fever patients. A clinical ef...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1982-09-01 00:00:00
abstract：:Both the outer and inner nose as well as the position of the parietal bones of 972 patients at an age of 3 to 82, were examined giving evidence of the configuration of the infant's head at birth and thereby of the "severity" of the birth. In comparison with the sectio-patients the configuration of the infant's head in...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：:Snoring is a significant problem both for the patient and for the bedpartner. It is well known that nasal stuffiness can contribute to snoring, and sleep quality may deteriorate because of the snoring. Nasal dilation can reduce snoring and improve sleep. Thirty-five habitual snorers (18 female, 17 male) and their bedp...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:Dysregulation of the autonomic system can affect sinonasal physiological function and may exacerbate the symptom burden associated with rhinosinusitis. However, the association between autonomic dysfunction and chronic rhinosinusitis (CRS) has seldom been studied. Here, we investigated the relationship betwe...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin18.005
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Chronic rhinosinusitis (CRS) with nasal polyps is characterized by eosinophilic infiltration. This study hypothesized that the aggregation of the mucosal pathology during remodeling is related to infiltrating eosinophils in patients with such nasal polyps. OBJECT:To clarify the pathogenetic role of eosinoph...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin08.109
更新日期：2009-09-01 00:00:00
abstract：:Septal perforations 4 mm or less in diameter have been successfully closed in eight out of ten patients with interposition of fascia temporalis. Larger perforations could, however, not be closed with this technique. Silicone buttons were helpful in half of the patients with perforations 5-20 mm. In larger ones they we...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVES/HYPOTHESIS:Adequate air conditioning in the nasal airways is mandatory for respiration and gas exchange in the lower respiratory tract. The aim of the present study was to measure relative humidity and temperature in the airstream at different sites within the nasal cavity for mapping of relative humidity an...
journal_title：Rhinology
pub_type： 临床试验,杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:We compared the efficacy and safety of 5 mg cetirizine (CTZ), 120 mg pseudoephedrine retard (PER) and their combination (COM), given twice daily for three weeks, for the treatment of perennial allergic rhinitis. Two hundred and ten evaluable patients (97 males and 113 females) were included in the study and randomly a...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1996-06-01 00:00:00
