Abstract:
:A total of 22 asymptomatic patients with a documented history of allergic rhinitis participated in this single-centre, double-blind, randomized, placebo-controlled, cross-over trial undertaken to assess the efficacy and tolerability of levocabastine nasal spray (0.5 mg/ml) in the prevention of allergen-induced nasal symptoms. Objective assessment of nasal symptoms revealed that the severity of sneezing was significantly lower following treatment with levocabastine (p < 0.001), with rhinorrhoea also tending to be less severe in the levocabastine-treated group (0.05 < p < 0.1). Rhinomanometry and acoustic rhinometry failed to reveal any significant intergroup differences, and there were no differences in nasal albumin concentrations between the two treatment groups. Patients' VAS ratings revealed significant differences in favour of levocabastine for sneezing (p < 0.001) and itching (p < 0.05), with the severity of rhinorrhoea also tending to be lower during treatment with this topical antihistamine (0.05 < p < 0.1). The mean total symptom score was also significantly lower in levocabastine-treated patients (p < 0.05). Levocabastine was well tolerated. Only two adverse events were reported: fatigue in one patient, and vesicular rash with facial oedema and urticaria in another. In conclusion, intranasal levocabastine provided effective protection from nasal allergen challenge and would appear to be a valuable therapeutic approach in patients with allergic rhinitis.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Bachert C,Wagenmann M,Vossen-Holzenkamp Ssubject
Has Abstractpub_date
1996-09-01 00:00:00pages
140-3issue
3eissn
0300-0729issn
1996-8604journal_volume
34pub_type
临床试验,杂志文章,随机对照试验相关文献
RHINOLOGY文献大全abstract::Experiments in growing rabbits showed the great importance of the nasal septum for the postnatal growth of the facial skeleton. The influence of surgical procedures on the morphogenetic function of the nasal septum was investigated. The effects of unilateral and bilateral elevation of the mucoperichondrium and of subm...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:Rhinitis prevalence is increasing worldwide and is frequently associated with asthma, for which it is a risk factor. The aims of the study were to characterise the adult population with rhinitis attending the Cova da Beira Hospital Allergy Clinic, and to assess the relationship between rhinitis and asthma. ...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract::There are two basic types of septal deformity, namely anterior nasal deformity and combined septal deformity, which may occur independently or both together. They are considered to be acquired from different types of pressures on the foetus during pregnancy or parturition. The incidence of anterior nasal deformity was...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::A technique of microsurgical ethmoidectomy by a nasal route was devised for and applied to the treatment of nasal polyposis. A description of the operative procedure and the results in 30 cases with a 3-5 years of follow-up are reported. ...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00
abstract::Paranasal sinus osteoma is a slow-growing, benign, encapsulated bony tumour that may be commonly asymptomatic, being detected incidentally in 1% of plain sinus radiographs or in 3% sinus computerized tomographic scans. In a patient presenting with epiphora and nasal obstruction, computed tomography disclosed a giant o...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Orbital decompression and, in some cases, decompression of the optic nerve are the principal surgical procedures used for treatment of moderate or severe Graves' orbitopathy (GO). Histological examination of the surgical specimens of the ethmoid revealed a wide spectrum of inflammatory mucosal changes. The charts of 6...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Residual sleepiness after continuous positive airway pressure (CPAP) is a critical problem in some patients with obstructive sleep apnea syndrome (OSAS). However, nasal surgery is likely to reduce daytime sleepiness and feelings of unrefreshed sleep. The aim of this study is to clarify the effects of nasal su...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin17.026
更新日期:2017-09-01 00:00:00
abstract::With chronic maxillary sinusitis the pathological changes in the diseased mucosa used to be considered irreversible, thus necessitating its radical removal, which is only possible with the Caldwell-Luc operation. The discovery of the reversibility of the pathology caused a shift from the Caldwell-Luc towards endonasal...
journal_title:Rhinology
pub_type: 杂志文章,评审
doi:
更新日期:1988-03-01 00:00:00
abstract::The possible occurrence of adrenergic and non-adrenergic vasoconstrictor mechanisms has been studied in human nasal mucosa biopsies. The tissue contractions (reflecting vascular tone variation) in response to exogenous noradrenaline (NA), neuropeptide Y (NPY) and somatostatin (SOM) were measured in vitro. Dose-depende...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::An effective system for scoring pathological changes on CT scans of the paranasal sinuses has been developed by Lund & Mackay. We have performed an audit using 100 outpatients with nasal symptoms and found that adherence to guidelines prior to ordering CT scans of the paranasal sinuses correlates with an increased ave...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:The aim of this multicentre study was to systematically analyse the strengths and weaknesses in the surgical training for endoscopic sinus surgery (ESS) and identify measures that may improve training. METHODOLOGY:Using a structured questionnaire, 133 participants of ESS courses in seven centres in Germany,...
journal_title:Rhinology
pub_type: 杂志文章,多中心研究
doi:10.4193/Rhino11.266
更新日期:2012-09-01 00:00:00
abstract::Nasal septal abscess is an uncommon condition. Most commonly it is secondary to nasal trauma, which leads to haematoma, and subsequent abscess formation. There are other less common causes like sinusitis, dental infections and furunculosis. Non-traumatic nasal septal abscess has also been reported in immunocompromised...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhino08.142
更新日期:2009-12-01 00:00:00
abstract::Three hundred and thirty-four measurements of bilateral and unilateral nasal resistance (at delta P 1.0 cm H2O and by time averaging) in 233 adults were carried out by posterior rhinomanometry with a head-out body plethysmograph. Total nasal resistances, calculated by the equation of Ohm's Law for parallel resistors f...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Medical therapy including appropriate antibiotic treatment is advocated for the management of chronic rhinosinusitis (CRS), with sinus surgery reserved for treatment failures. This study investigates the microbiology of CRS and their response to culture-directed antibiotic treatment. METHODS:Sinus aspirates...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhino09.071
更新日期:2010-12-01 00:00:00
abstract::Patients requiring home oxygen can experience drying and crusting of nasal mucosa. On occasion it can be severe causing significant discomfort. In this report we present such a case. To prevent nasal airflow and hence reduce symptoms the patient was fitted with a nasal obturator. The use of the nasal obturator resulte...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::Two radiopaque implants were inserted into each left and right nasal bone in five female rabbits. Ventrodorsal cephalometric radiographs were taken at 6 and 16 weeks of age. From these radiographs, separate tracings were made on matte acetate paper of the left and right nasal bone regions including the radiopaque impl...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract::Schwannoma of the nasal cavity or the sinuses is a rare condition. We report a small series of five consecutive patients; three males and two females, age range 22-81 years, all Caucasian. Symptoms were typically non-specific, and the tumours were often quite large when diagnosed, being locally infiltrating and even d...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::The results of a septoplasty because of a nasal obstruction were studied in 261 children, their ages ranging from 4 to 14. No arrest of nasal growth after the septoplasty and osteotomies was recorded. Histological examination revealed a cartilaginous regeneration at the borders of the resected septal cartilage in 15 c...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Several texts detail the possible complications of nasal reconstruction but few critically describe a series. We present an audit of the complications of 95 major nasal reconstructions. METHODS:This is a retrospective analysis of 95 consecutive major nasal reconstructions (49 male, 46 female, aged between 4...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin09.050
更新日期:2010-03-01 00:00:00
abstract::The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS an...
journal_title:Rhinology
pub_type: 杂志文章,实务指引
doi:10.4193/Rhin20.600
更新日期:2020-02-20 00:00:00
abstract::We report our experience with 10 cases of sphenoidal aspergillomas treated by endoscopic sinus surgery (ESS). Chronic symptoms such as cough, post-nasal discharge, dysphonia and even facial pain can be encountered in the history. Computerised tomography and, occasionally, magnetic resonance imaging are of great help i...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::Since the outbreak of the pandemic, anecdotal observations have been accumulating rapidly that sudden anosmia and dysgeusia are peculiar symptoms associated with the COVID-19 infection. Prof C. Hopkins, as President of British Rhinological Society, published a letter describing "the loss of sense of smell as a marker ...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin20.159
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Progressive advances in proteomic technology has improved our understanding of the chronic rhinosinusitis (CRS) pathogenesis and endotypes. This scoping review aims to present a comprehensive and descriptive analysis of nasal mucosa and mucus proteome of CRS patients. METHODOLOGY:Studies investigating the p...
journal_title:Rhinology
pub_type: 杂志文章,评审
doi:10.4193/Rhin20.034
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:During endoscopic surgery, it is difficult to ascertain the anatomical landmarks once the anatomy is fiddled with or if the operating area is filled with blood. An augmented reality system will enhance the endoscopic view and further enable surgeons to view hidden critical structures or the results of preope...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::Prevention of chronic rhinosinusitis remains a true societal challenge, as prevention of this highly prevalent non-communicable disease will significantly reduce socio-economic costs and improve the overall well-being of the large group of affected individuals. In alignment with the health priorities of national gover...
journal_title:Rhinology
pub_type: 社论
doi:10.4193/Rhin18.404
更新日期:2018-12-01 00:00:00
abstract::We report one case of schwannoma of the pterygopalatine fossa. The pre-operative management and post-operative follow-up are presented. For this uncommon localization, we propose an endoscopic approach via the nasal fossa and the maxillary sinus. The advantages and limitations of this technique are discussed. ...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Different from rhinoliths, the paranasal gossypiboma is a foreign body, such as a surgical sponge, left in the nasal cavity. It is a rare, frequently misdiagnosed disease that has rarely been reported. We summarize its clinical characteristics, management, and possible risk factors. METHODOLOGY:We reviewed ...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin16.341
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES/HYPOTHESIS:The Modified Endoscopic Lothrop procedure (MELP) or Draf 3 is a complex procedure, performed for chronic frontal sinusitis that is refractory to standard functional endoscopic sinus surgery. The procedure involves drilling of the frontal T (formed by the septum and middle turbinate`s attachment to...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhino10.248
更新日期:2011-06-01 00:00:00
abstract::Empirical antibiotics constitute the cornerstone of medical therapy for chronic sinusitis due to difficulties of obtaining cultures from the paranasal sinuses. Indirect isolation of the pathogenic microorganisms outside the paranasal sinuses with a non-invasive method may enable administration of specific antibiotics....
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the anatomic variations of neurovascular structures adjacent to the sphenoid sinus and their agreement between right and left sides as well as differences between sexes. METHODS:Forty-five cadavers were dissected (24 men, and differences between sexes and agreement of anatomic variations of the ...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00