The effect of 2,3-butanedione 2-monoxime (BDM) on ventricular trabeculae from the avian heart.

abstract：:The effects of a ramp stretch (amplitude <6% muscle fibre length (L0), speed < 13L0 s(-1)) on twitch tension and twitch tension re-development were examined in intact mammalian (rat) fast and slow muscle fibre bundles. The experiments were done in vitro at 20 degrees C and at an initial sarcomere length of 2.68 microm...

journal_title：Journal of muscle research and cell motility

authors： Mutungi G,Ranatunga KW

更新日期：2001-01-01 00:00:00

abstract：:Cleavage of vertebrate muscle tropomyosin by bacterial Omp T produces an amino-terminally truncated product (residues 7-284). The proteolysed protein, which is resolved from the parent by electrophoresis in the presence of sodium dodecylsulphate, can be generated from a variety of striated and smooth muscle tropomyosi...

journal_title：Journal of muscle research and cell motility

authors： Goonasekara CL,Gallivan LJ,Jackman DM,Heeley DH

更新日期：2007-01-01 00:00:00

abstract：:In this study alterations are characterized which occur, in myocardial force development morphological appearance and protein composition, during the development of cardiac hypertrophy and heart failure in monocrotaline (MCT) treated rats. The transition from cardiac hypertrophy to heart failure was studied by compari...

journal_title：Journal of muscle research and cell motility

authors： Korstjens IJ,Rouws CH,van der Laarse WJ,Van der Zee L,Stienen GJ

更新日期：2002-01-01 00:00:00

abstract：:While the migration of capillary endothelial cells is believed central to the process of new blood vessel development in vivo, the biochemical basis for endothelial motility is unknown. Herein, we demonstrate that retina-derived growth factor (RDGF), a mitogen for endothelial cells (EC), stimulates the migration of mi...

journal_title：Journal of muscle research and cell motility

authors： Herman IM,D'Amore PA

更新日期：1984-12-01 00:00:00

abstract：:Dihydropyridine receptors (DHPRs), ryanodine receptors (RyRs), and triadin are major components of triads of mature skeletal muscle and play crucial roles in Ca2+ release in excitation-contraction (E-C) coupling. We investigated the expression and localization of these proteins as well as intracellular Ca2+ transients...

journal_title：Journal of muscle research and cell motility

authors： Tanaka H,Furuya T,Kameda N,Kobayashi T,Mizusawa H

更新日期：2000-01-01 00:00:00

abstract：:The pattern of spontaneous skeletal muscle degeneration and clinical recovery hindlimb muscles of the mdx mutant mouse was examined for functional and metabolic confirmation of apparent structural regeneration. The contractile properties, histochemical staining and myosin light chain and parvalbumin contents of extens...

journal_title：Journal of muscle research and cell motility

authors： Anderson JE,Bressler BH,Ovalle WK

更新日期：1988-12-01 00:00:00

abstract：:It has been proposed that in striated muscle inositol 1,4,5-trisphosphate (InsP3) may serve as a chemical transmitter linking membrane depolarization to Ca(2+)-release from the sarcoplasmic reticulum. Key to that hypothesis of excitation-concentration (EC) coupling was the observation that skinned muscle fibres contra...

journal_title：Journal of muscle research and cell motility

authors： Hannon JD,Lee NK,Yandong C,Blinks JR

更新日期：1992-08-01 00:00:00

abstract：:We investigated the expression of neuronal nitric oxide synthase (nNOS) and dystrophin in the regenerating skeletal muscles of rats after cardiotoxin-induced myonecrosis by immunohistochemical studies and western blot analysis. In normal muscles, nNOS was moderately immunostained on type 2B fibers, but was faintly imm...

journal_title：Journal of muscle research and cell motility

authors： Hoshino S,Ohkoshi N,Ishii A,Shoji S

更新日期：2002-01-01 00:00:00

abstract：:The time course of shortening at zero load was studied by the slack test method during tetanic contractions in isolated, single, slow muscle fibres of the crayfish. In 28 of 32 shortenings (from 14 different fibres) a biphasic shortening was seen, which consisted of an initial high-velocity phase lasting 3.3-20.8 ms a...

journal_title：Journal of muscle research and cell motility

authors： Tameyasu T

更新日期：1992-12-01 00:00:00

abstract：:The β-adrenergic receptor stimulation improves endurance in fast twitch muscles and these effects are sensitive to extracellular Ca2+ influx. Present study is aimed to determine the effects of adrenaline, with different concentrations of extracellular Ca2+[Formula: see text], on the contractility and endurance of slow...

journal_title：Journal of muscle research and cell motility

authors： Rizvi MH,Abdul Azeem M,Savanur A

更新日期：2019-12-01 00:00:00

abstract：:It is generally thought that the rapid relaxation of fast muscles is facilitated by the Ca(2+) binding protein parvalbumin (Parv). Indeed superfast swimbladder (SWB) muscle of toadfish contains the largest concentration of this protein ever observed (up to 1.5 mM). At 15 degrees C toadfish perform a 100 Hz call, 400 m...

journal_title：Journal of muscle research and cell motility

authors： Tikunov BA,Rome LC

更新日期：2009-01-01 00:00:00

abstract：:A confocal microscope was used to investigate the reversible vacuolation of frog skeletal muscle fibres produced by the efflux and entry of glycerol (80-100 mM). The formation, development and disappearance of vacuoles was observed in the fibres by staining simultaneously with two fluorescent membrane probes, RH414 an...

journal_title：Journal of muscle research and cell motility

authors： Krolenko SA,Amos WB,Lucy JA

更新日期：1995-08-01 00:00:00

abstract：:Rigor complexes between actin and myosin have been shown to cause increased binding of Ca2+ to troponin C. A similar effect of force-generating crossbridges has been suggested as an explanation for the coupling between load and activation which has been observed in skeletal and cardiac muscle. The goal of this study w...

journal_title：Journal of muscle research and cell motility

authors： Fuchs F

更新日期：1985-08-01 00:00:00

abstract：:The developmental expression of nebulin was studied in embryonic chick skeletal muscle cells in vitro by means of immunofluorescence microscopy. Initially nebulin appeared homogeneously or in a punctate form in the cytoplasm, and then it was assembled into I-Z-I-like complexes containing actin and alpha-actinin but no...

journal_title：Journal of muscle research and cell motility

authors： Komiyama M,Zhou ZH,Maruyama K,Shimada Y

更新日期：1992-02-01 00:00:00

abstract：:Single twitch muscle fibres have been isolated from various parts of the iliofibularis muscle of Xenopus laevis. After measurements of their isotonic contractile properties, myosin extraction was performed on individual fibres and the extract analysed by various forms of gel electrophoresis. In agreement with previous...

journal_title：Journal of muscle research and cell motility

authors： Lännergren J

更新日期：1987-06-01 00:00:00

abstract：:RNA-binding motif protein 3 (RBM3), a stress-inducible RNA-binding protein that increases protein synthesis and confers cell protection in multiple cell types, has been identified as a possible regulator of skeletal muscle mass. Therefore, the primary aim of this study was to examine the impact of elevated RBM3 on ske...

journal_title：Journal of muscle research and cell motility

authors： Van Pelt DW,Confides AL,Judge AR,Vanderklish PW,Dupont-Versteegden EE

更新日期：2018-04-01 00:00:00

abstract：:The distribution of Ca2+ and Mg2+ among the 'regulatory' cation binding sites of troponin (T-sites) and the strong, Ca2+-Mg2+ binding sites of troponin and parvalbumins (P-sites) in the sarcoplasm of a muscle was calculated. At rest, 60% of the T-sites were metal free, while 92% of the P-sites were loaded with Mg2+. I...

journal_title：Journal of muscle research and cell motility

authors： Gillis JM,Thomason D,Lefèvre J,Kretsinger RH

更新日期：1982-12-01 00:00:00

abstract：:Small but statistically significant shifts (hysteresis) between the up (increasing tension direction) and down (decreasing tension) pCa/tension relation for several muscle types of the rabbit and rat were found. The largest shift is, at most, 0.093 p units or 60% of that reported for the barnacle muscle. The direction...

journal_title：Journal of muscle research and cell motility

authors： Brandt PW,Gluck B,Mini M,Cerri C

更新日期：1985-04-01 00:00:00

abstract：:The term 'microtubule dynamics' is often used to describe assembly/disassembly characteristics of this important cytoskeletal polymer. The ability to image microtubules in live Dictyostelium cells has revealed additional dynamic components, acting on the individual assembled tubules. At least two separate forces are i...

journal_title：Journal of muscle research and cell motility

authors： Koonce MP,Khodjakov A

更新日期：2002-01-01 00:00:00

abstract：:The details of the global and local structure and function of titin, a giant filamentous intrasarcomeric protein are largely undiscovered. Here we discuss a combination of bulk-solution and novel single-molecule techniques that may lend unique insights into titin's molecular dynamic, structural and mechanical characte...

journal_title：Journal of muscle research and cell motility

authors： Kellermayer MS,Grama L

更新日期：2002-01-01 00:00:00

abstract：:Single muscle fiber sodium dodecyl sulfate polyacrylamide gel-electrophoresis (SDS-PAGE) is a sensitive technique for determining skeletal muscle myosin heavy chain (MHC) composition of human biopsy samples. However, the number of fibers suitable to represent fiber type distribution via this method is undefined. Muscl...

journal_title：Journal of muscle research and cell motility

authors： Murach KA,Bagley JR,McLeland KA,Arevalo JA,Ciccone AB,Malyszek KK,Wen Y,Galpin AJ

更新日期：2016-04-01 00:00:00

abstract：:Nebulin is an integral protein of skeletal muscle thin filaments and probably acts as a ruler for the thin filament length. Cardiac muscles of higher vertebrates have been shown earlier to lack nebulin. Instead in human and chicken cardiac muscle the much smaller protein nebulette replaces nebulin. Since nebulette is ...

journal_title：Journal of muscle research and cell motility

authors： Fock U,Hinssen H

更新日期：2002-01-01 00:00:00

abstract：:The effect of Ca2+ activation on the apparent rate constant governing the dissociation of force generating myosin crossbridges was studied in skinned rabbit adductor magnus fibres (fast-twitch) at 21 +/- 1 degree C. Simultaneous measurements of Ca2(+)-activated isometric force and ATPase activity were conducted in par...

journal_title：Journal of muscle research and cell motility

authors： Kerrick WG,Potter JD,Hoar PE

更新日期：1991-02-01 00:00:00

abstract：:In frog semitendinosus muscle the descending limb of the length-tension curve is shifted rightward relative to that of tibialis anterior. Both the plateau right corner and the zero-force intercept are equally shifted. To investigate the reason for this shift, we compared filament lengths in the two muscles. Single fib...

journal_title：Journal of muscle research and cell motility

authors： Trombitás K,Frey L,Pollack GH

更新日期：1993-04-01 00:00:00

abstract：:To explain observed differences in the activation dependence of force redevelopment kinetics between cardiac and skeletal muscle, two numerical models of contractile regulation by Ca2+ were investigated. Ca2+ binding and force production were each modelled as two-state processes with forward and reverse rate constants...

journal_title：Journal of muscle research and cell motility

authors： Hancock WO,Huntsman LL,Gordon AM

更新日期：1997-12-01 00:00:00

abstract：:Cytokinesis is the mechanical process that allows the simplest unit of life, the cell, to divide, propagating itself. To divide, the cell converts chemical energy into mechanical energy to produce force. This process is thought to be active, due in large part to the mechanochemistry of the myosin-II ATPase. The cell's...

journal_title：Journal of muscle research and cell motility

authors： Robinson DN,Girard KD,Octtaviani E,Reichl EM

更新日期：2002-01-01 00:00:00

abstract：:The effects of 2,3-butanedione monoxime (BDM) on contraction characteristics were studied at 5 degrees C in single intact fibres isolated from the tibialis anterior muscle of the frog. The force-velocity relation was determined using the controlled-velocity method in either whole fibres or short fibre segments in whic...

journal_title：Journal of muscle research and cell motility

authors： Bagni MA,Cecchi G,Colomo F,Garzella P

更新日期：1992-10-01 00:00:00

abstract：:There is evidence to suggest that 8 nm calcium transport particles in the sarcoplasmic reticulum are involved in the regulation of twitch properties in adult muscles. We have studied ultrastructural characteristics of the sarcoplasmic reticulum in relation to previously defined physiological changes that take place in...

journal_title：Journal of muscle research and cell motility

authors： Gauthier GF,Hobbs AW

更新日期：1986-04-01 00:00:00

abstract：:The aim of the present study was to examine the temperature dependence of active force in lengthening and shortening muscle. Experiments were done, in vitro, on bundles of intact fibres (fibre length L(0) ~2 mm; sarcomere length ~2.5 μm) isolated from a rat fast muscle (flexor hallucis brevis) and a ramp length change...

journal_title：Journal of muscle research and cell motility

authors： Roots H,Pinniger GJ,Offer GW,Ranatunga KW

更新日期：2012-10-01 00:00:00

abstract：:temporaria (0.9-2.5degrees C) were stimulated to produce a 1 s isometric tetanus at regular intervals until constant mechanical responses were attained. Various degrees of force depression ("fatigue") were produced by decreasing the contraction interval from 30 or 15 min (control to 120, 60, 30 and 15s, respectively. ...

journal_title：Journal of muscle research and cell motility

authors： Edman KA,Mattiazzi AR

更新日期：1981-09-01 00:00:00