Filament lengths in frog semitendinosus and tibialis anterior muscle fibres.

abstract：:Phosphorylation of skeletal myosin regulatory light chain (RLC) occurs in fatigue and may play a role in the inhibition of shortening velocities observed in vivo. Forces and shortening velocities were measured in permeabilized rabbit psoas fibers with either phosphorylated or dephosphorylated RLCs and in the presence ...

journal_title：Journal of muscle research and cell motility

authors： Stewart M,Franks-Skiba K,Cooke R

更新日期：2009-01-01 00:00:00

abstract：:Guinea-pig soleus muscles were denervated and electrically stimulated for periods of 43 to 66 days. Stimuli were in 1 s bursts of 40 Hz pulses, repeated every 5 min. Other guinea-pigs were denervated for 82 days without stimulation and, in a third group, the soleus muscle was necrotized and allowed to regenerate witho...

journal_title：Journal of muscle research and cell motility

authors： Lewis DM,al-Amood WS,Schmalbruch H

更新日期：1997-10-01 00:00:00

abstract：:The in vivo state of assembly of myosin in vertebrate smooth muscle is controversial. In vitro studies on purified smooth muscle myosin show that it is monomeric (10S) under relaxing conditions and filamentous under contraction conditions. Electron microscopic and antibody labelling studies of intact smooth muscles, o...

journal_title：Journal of muscle research and cell motility

authors： Xu JQ,Gillis JM,Craig R

更新日期：1997-06-01 00:00:00

abstract：:Tropomyosin-kappa (TPM1-κ) is a newly discovered tropomyosin (TM) isoform that is exclusively expressed in the human heart and generated by an alternative splicing of the α-TM gene. We reported that TPM1-κ expression was increased in the hearts of patients with chronic dilated cardiomyopathy (DCM). To increase our und...

journal_title：Journal of muscle research and cell motility

authors： Karam CN,Warren CM,Rajan S,de Tombe PP,Wieczorek DF,Solaro RJ

更新日期：2011-03-01 00:00:00

abstract：:The fine structure of leech body wall muscles, has been analysed under great length variations. All the measurable parameters of the fibre (distance between thick filaments, sarcomere and A band width, percentage of actin crowns around myosin filaments, fibre radius) at different elongations were tested with equations...

journal_title：Journal of muscle research and cell motility

authors： Lanzavecchia G,de Eguileor M,Valvassori R

更新日期：1985-10-01 00:00:00

abstract：:Nebulin is an integral protein of skeletal muscle thin filaments and probably acts as a ruler for the thin filament length. Cardiac muscles of higher vertebrates have been shown earlier to lack nebulin. Instead in human and chicken cardiac muscle the much smaller protein nebulette replaces nebulin. Since nebulette is ...

journal_title：Journal of muscle research and cell motility

authors： Fock U,Hinssen H

更新日期：2002-01-01 00:00:00

abstract：:The five possible analogues of ATP and the three possible analogues of ADP which contain single non-bridging sulphur atoms instead of oxygen in the polyphosphate structure have been used as probes of the interaction of nucleotides with myosin and actomyosin. Evidence is presented for the requirement of an alpha, beta,...

journal_title：Journal of muscle research and cell motility

authors： Goody RS,Hofmann W

更新日期：1980-03-01 00:00:00

abstract：:Heart disease is a leading cause of death in patients with Duchenne muscular dystrophy (DMD). Patients with DMD lack the protein dystrophin, which is widely expressed in striated muscle. In skeletal muscle, the loss of dystrophin results in dramatically decreased expression of the dystrophin associated glycoprotein co...

journal_title：Journal of muscle research and cell motility

authors： Sharpe KM,Premsukh MD,Townsend D

更新日期：2013-12-01 00:00:00

abstract：:Ryanodine receptors (RyRs) are huge homotetrameric Ca2+ release channels localized to the sarcoplasmic reticulum. RyRs are responsible for the release of Ca2+ from the SR during excitation-contraction coupling in striated muscle cells. Recent revolutionary advancements in cryo-electron microscopy have provided a numbe...

journal_title：Journal of muscle research and cell motility

authors： Ogawa H,Kurebayashi N,Yamazawa T,Murayama T

更新日期：2020-02-10 00:00:00

abstract：:Chronic low-frequency electrical stimulation of rabbit fast-twitch skeletal muscle induces increased levels of two intermediate filament proteins, desmin and vimentin, during the first 3 weeks of stimulation. These increases occur over the same timecourse as reported shifts in alpha-actinin expression and increased Z-...

journal_title：Journal of muscle research and cell motility

authors： Baldi JC,Reiser PJ

更新日期：1995-12-01 00:00:00

abstract：:Mechanical properties of myofibrillar bundles from single chemically skinned fibres from the superficial abdominal flexor muscle of the Norway lobster Nephrops norvegicus were measured, and the protein content of these fibres was analysed by SDS-PAGE. Two slow fibre phenotypes (S1, S2) were distinguished on the basis ...

journal_title：Journal of muscle research and cell motility

authors： Holmes JM,Hilber K,Galler S,Neil DM

更新日期：1999-04-01 00:00:00

abstract：:Skeletal muscle repair requires the migration of myoblasts (activated satellite cells) both to the injury site and then within the wound to facilitate cellular alignment in preparation for differentiation, fusion and eventual healing. Along this journey, the cells encounter a range of soluble and extracellular matrix ...

journal_title：Journal of muscle research and cell motility

authors： Goetsch KP,Myburgh KH,Niesler CU

更新日期：2013-12-01 00:00:00

abstract：:The ability for muscle to repeatedly generate force is limited by fatigue. The cellular mechanisms behind muscle fatigue are complex and potentially include breakdown at many points along the excitation-contraction pathway. In this paper we construct a mathematical model of the skeletal muscle excitation-contraction p...

journal_title：Journal of muscle research and cell motility

authors： Shorten PR,O'Callaghan P,Davidson JB,Soboleva TK

更新日期：2007-01-01 00:00:00

abstract：:The trimeric protein AMP-activated protein kinase (AMPK) is an important sensor of energetic status and cellular stress, and mutations in genes encoding two of the regulatory γ subunits cause inherited disorders of either cardiac or skeletal muscle. AMPKγ2 mutations cause hypertrophic cardiomyopathy with glycogen depo...

journal_title：Journal of muscle research and cell motility

authors： Pinter K,Grignani RT,Watkins H,Redwood C

更新日期：2013-12-01 00:00:00

abstract：:Actin filaments are major components of the cytoskeleton in eukaryotic cells and are involved in vital cellular functions such as cell motility and muscle contraction. Tmod and TM are crucial constituents of the actin filament network, making their presence indispensable in living cells. Tropomyosin (TM) is an alpha-h...

journal_title：Journal of muscle research and cell motility

authors： Colpan M,Moroz NA,Kostyukova AS

更新日期：2013-08-01 00:00:00

abstract：:Homozygous calsequestrin 2 (CASQ2) point mutations leads to catecholaminergic polymorphic ventricular tachycardia: a common pathogenetic feature appears to be the drastic reduction of mutant CASQ2 in spite of normal transcription. Comparative biochemical analysis of R33Q and D307H knock in mutant mice identifies diffe...

journal_title：Journal of muscle research and cell motility

authors： Valle G,Arad M,Volpe P

更新日期：2020-09-01 00:00:00

abstract：:Hodges and his colleagues identified a 12 amino acid fragment of troponin I (TnI-ip) that inhibits Ca(2+)-activated force and reduces the effectiveness Ca(2+) as an activator. To understand the role of troponin C (TnC) in the extended cooperative interactions of thin filament activation, we compared the effect of TnI-...

journal_title：Journal of muscle research and cell motility

authors： Schachat F,Brandt PW

更新日期：2013-05-01 00:00:00

abstract：:Protein kinase C (PKC) is known to play important roles in integrin mediated cell spreading. This study investigated the role of PKC during insulin mediated muscle cell spreading, which was independent of integrin alpha5. We found that PKC-alpha becomes active and localise to membrane during insulin mediated cell spre...

journal_title：Journal of muscle research and cell motility

authors： Goel HL,Dey CS

更新日期：2002-01-01 00:00:00

abstract：:Scallop S1 has a region sensitive to tryptic hydrolysis not found thus far in S1s of other species, located 65K from the N-terminus as determined by SDS/polyacrylamide-gel electrophoresis. In the presence of actin the S1 heavy chain is preferentially cleaved at this site. The high-salt EDTA and calcium ATPase activiti...

journal_title：Journal of muscle research and cell motility

authors： Szentkiralyi EM

更新日期：1987-08-01 00:00:00

abstract：:The kinetics of smooth muscle are thought to be partially determined by the level of the expression of the 7 amino acid insert, SMB, in the myosin heavy chain, as SMB is generally expressed at higher levels in faster smooth muscle. In this study, we determined the role of this insert on shortening velocity and force r...

journal_title：Journal of muscle research and cell motility

authors： Karagiannis P,Babu GJ,Periasamy M,Brozovich FV

更新日期：2004-01-01 00:00:00

abstract：:The hypothesis that calmodulin (CaM) may act as a positive modulator of junctional SR Ca2+-release channel/ ryanodine receptor (RyRl) rests largerly on the demonstrated capacity of CaM to interact structurally and functionally with RyRl at pCa > 8 (Tripathy et al., 1995). The goal of the present [3H]-ryanodine binding...

journal_title：Journal of muscle research and cell motility

authors： Damiani E,Margreth A

更新日期：2000-01-01 00:00:00

abstract：:Five monoclonal antibodies that react with different regions of myosin light chain 1 from human ventricular myocardial muscle were used to obtain information on interactions between the light chain 1 and heavy chains and generally on the tertiary structure of the light chain 1 within the myosin head. We performed West...

journal_title：Journal of muscle research and cell motility

authors： Cornillon B,Cathiard AM,Eldin P,Anoal M,Cardinaud R,Liautard JP,Le Cunff M,Mornet D,Pons F,Leger J

更新日期：1992-06-01 00:00:00

abstract：:Myomesin-I (also known as Skelemin) is a approximately 185 kDa protein, which is highly expressed in striated muscle. It contains the prototypic class-I (type-III fibronectin) and class-II (C2-immunoglobulin) motifs. Previous studies have shown the presence of Myomesin-I at the M-line of the sarcomere, where it is tho...

journal_title：Journal of muscle research and cell motility

authors： Reddy KB,Fox JE,Price MG,Kulkarni S,Gupta S,Das B,Smith DM

更新日期：2008-01-01 00:00:00

abstract：:The aim of the study was to investigate sex-related differences in contractile properties, parameters of action potentials, and mechanisms of force regulation of motor units in the rat soleus muscle, which is a frequent experimental model in animal research. It was revealed that the mean mass of the muscle in males wa...

journal_title：Journal of muscle research and cell motility

authors： Drzymała-Celichowska H,Krutki P

更新日期：2015-06-01 00:00:00

abstract：:Single twitch muscle fibres have been isolated from various parts of the iliofibularis muscle of Xenopus laevis. After measurements of their isotonic contractile properties, myosin extraction was performed on individual fibres and the extract analysed by various forms of gel electrophoresis. In agreement with previous...

journal_title：Journal of muscle research and cell motility

authors： Lännergren J

更新日期：1987-06-01 00:00:00

abstract：:Stretchin-klp is a newly described protein in Drosophila indirect flight muscles (IFM) that migrates on SDS gels as two distinct components of approximately 225 and 231 kD. Although the larger isoform is IFM specific, the smaller stretchin-klp isoform is expressed not only in IFM, but also in wild-type tissues of the ...

journal_title：Journal of muscle research and cell motility

authors： Patel SR,Saide JD

更新日期：2005-01-01 00:00:00

abstract：:Skeletal muscle tissue is mechanosensitive, as it is able to sense mechanical impacts and to translate these into biochemical signals making the tissue adapt. Among its mechanosensitive nature, skeletal muscle tissue is the largest metabolic organ of the human body. Disturbances in skeletal muscle mechanosensing and m...

journal_title：Journal of muscle research and cell motility

authors： Pingel J,Suhr F

更新日期：2017-08-01 00:00:00

abstract：:We found that the active tension of C2C12 myotubes that had been subjected to artificial exercise for ~10 days decreased rapidly after termination of the artificial exercise. When differentiated C2C12 myotubes were subjected to continuous 1 Hz artificial exercise for ~10 days, the active tension increased to ~4× compa...

journal_title：Journal of muscle research and cell motility

authors： Fujita H,Hirano M,Shimizu K,Nagamori E

更新日期：2010-12-01 00:00:00

abstract：:Rigor complexes between actin and myosin have been shown to cause increased binding of Ca2+ to troponin C. A similar effect of force-generating crossbridges has been suggested as an explanation for the coupling between load and activation which has been observed in skeletal and cardiac muscle. The goal of this study w...

journal_title：Journal of muscle research and cell motility

authors： Fuchs F

更新日期：1985-08-01 00:00:00

abstract：:Single muscle fiber sodium dodecyl sulfate polyacrylamide gel-electrophoresis (SDS-PAGE) is a sensitive technique for determining skeletal muscle myosin heavy chain (MHC) composition of human biopsy samples. However, the number of fibers suitable to represent fiber type distribution via this method is undefined. Muscl...

journal_title：Journal of muscle research and cell motility

authors： Murach KA,Bagley JR,McLeland KA,Arevalo JA,Ciccone AB,Malyszek KK,Wen Y,Galpin AJ

更新日期：2016-04-01 00:00:00