Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.

abstract：:The fine structure of leech body wall muscles, has been analysed under great length variations. All the measurable parameters of the fibre (distance between thick filaments, sarcomere and A band width, percentage of actin crowns around myosin filaments, fibre radius) at different elongations were tested with equations...

journal_title：Journal of muscle research and cell motility

authors： Lanzavecchia G,de Eguileor M,Valvassori R

更新日期：1985-10-01 00:00:00

abstract：:Under muscle disuse conditions decrease of expression of MyHC of slow type, and sometimes of type IIa, as well as upregulation of expression of IIb and IId/x isoforms were observed. Through dephosphorylation and entry of NFAT molecules to the nucleus calcineurin/NFATc1 signaling pathway promotes upregulation of the sl...

journal_title：Journal of muscle research and cell motility

authors： Lomonosova YN,Turtikova OV,Shenkman BS

更新日期：2016-04-01 00:00:00

abstract：:Creatine kinase (CK) isoenzyme compositions of different types of single muscle fibres dissected from soleus (SOL) and extensor digitorum longus (EDL) muscles from rats were examined. CK isoenzymes were separated into cytoplasmic (CK-MM, CK-MB, CK-BB) (muscle, brain and hybrid types, respectively) and mitochondrial (m...

journal_title：Journal of muscle research and cell motility

authors： Yamashita K,Yoshioka T

更新日期：1991-02-01 00:00:00

abstract：:Myosin heavy chain species were investigated during development in avian pectoralis major muscles (type IIB fibres) by high resolution anion-exchange chromatography of the myosin head region, subfragment-1. At 15 days in ovo four distinct fast-type heavy chain species, I, II, III and IV, in order of elution, were iden...

journal_title：Journal of muscle research and cell motility

authors： Rushbrook JI,Weiss C,Yao TT

更新日期：1991-06-01 00:00:00

abstract：:Dr. John Gergely passed away on July 26, 2013 after a long and distinguished career. His publications spanned 67 years. He founded the Department of Muscle Research in the Retina Foundation (which later became the Boston Biomedical Research Institute) and served as director for 34 years. Dr. Gergely served on the edit...

journal_title：Journal of muscle research and cell motility

authors： Greaser ML,Potter JD,Thomas DD,Strasburg GM,Lehrer SS,Wang CL,Grabarek Z

更新日期：2013-12-01 00:00:00

abstract：:The trimeric protein AMP-activated protein kinase (AMPK) is an important sensor of energetic status and cellular stress, and mutations in genes encoding two of the regulatory γ subunits cause inherited disorders of either cardiac or skeletal muscle. AMPKγ2 mutations cause hypertrophic cardiomyopathy with glycogen depo...

journal_title：Journal of muscle research and cell motility

authors： Pinter K,Grignani RT,Watkins H,Redwood C

更新日期：2013-12-01 00:00:00

abstract：:Although a substantial literature exists on the in vitro polymerization of purified myosin, little is known about native thick filament assembly, remodeling or turnover. We have recently described a cell-free system (Bouche et al., 1988) to examine the interactions between thick filaments and soluble, newly synthesize...

journal_title：Journal of muscle research and cell motility

authors： Goldfine SM,Einheber S,Fischman DA

更新日期：1991-04-01 00:00:00

abstract：:The mechanical events following release of ATP from P3-1-(2-nitro)phenylethyladenosine-5'-triphosphate (caged-ATP) in skinned guinea pig taenia coli smooth muscle in rigor were investigated. A rigor force of about 25-35% of the maximal active force was obtained by removing ATP at the plateau of a maximal active contra...

journal_title：Journal of muscle research and cell motility

authors： Arner A,Goody RS,Rapp G,Rüegg JC

更新日期：1987-10-01 00:00:00

abstract：:The kinetics of smooth muscle are thought to be partially determined by the level of the expression of the 7 amino acid insert, SMB, in the myosin heavy chain, as SMB is generally expressed at higher levels in faster smooth muscle. In this study, we determined the role of this insert on shortening velocity and force r...

journal_title：Journal of muscle research and cell motility

authors： Karagiannis P,Babu GJ,Periasamy M,Brozovich FV

更新日期：2004-01-01 00:00:00

abstract：:The sarcomere of striated muscle is a very efficient machine transforming chemical energy into movement. However, a wrong distribution of the generated forces may lead to self-destruction of the engine itself. A well-known example for this is eccentric contraction (elongation of the sarcomere in the activated state), ...

journal_title：Journal of muscle research and cell motility

authors： Agarkova I,Ehler E,Lange S,Schoenauer R,Perriard JC

更新日期：2003-01-01 00:00:00

abstract：:We examined the tension responses induced by rapid temperature-jumps (T-jumps) applied at different times during twitch and tetanic contractions in small intact fibre bundles (5-10 fibres) isolated from a fast foot muscle (flexor hallucis brevis) of the rat. A rapid T-jump of 2-4 degrees C was induced by a 0.2 ms infr...

journal_title：Journal of muscle research and cell motility

authors： Coupland ME,Pinniger GJ,Ranatunga KW

更新日期：2005-01-01 00:00:00

abstract：:Mechanical properties of myofibrillar bundles from single chemically skinned fibres from the superficial abdominal flexor muscle of the Norway lobster Nephrops norvegicus were measured, and the protein content of these fibres was analysed by SDS-PAGE. Two slow fibre phenotypes (S1, S2) were distinguished on the basis ...

journal_title：Journal of muscle research and cell motility

authors： Holmes JM,Hilber K,Galler S,Neil DM

更新日期：1999-04-01 00:00:00

abstract：:Monoclonal antibodies (mAb's) have been raised against proteins in preparations of Z-discs isolated from honeybee fibrillar flight muscle. These antibodies have identified four Z-disc antigens on immunoblots of honeybee fibrillar proteins. Antibody alpha binds to the 90-100 kD protein, alpha-actinin; mAb P interacts w...

journal_title：Journal of muscle research and cell motility

authors： Saide JD,Chin-Bow S,Hogan-Sheldon J,Busquets-Turner L

更新日期：1990-04-01 00:00:00

abstract：:The developmental expression of nebulin was studied in embryonic chick skeletal muscle cells in vitro by means of immunofluorescence microscopy. Initially nebulin appeared homogeneously or in a punctate form in the cytoplasm, and then it was assembled into I-Z-I-like complexes containing actin and alpha-actinin but no...

journal_title：Journal of muscle research and cell motility

authors： Komiyama M,Zhou ZH,Maruyama K,Shimada Y

更新日期：1992-02-01 00:00:00

abstract：:Heat rate and tension were measured during the steady state of isovelocity shortening in frog sartorius muscles at two speeds (7.5 and 2.0 mm s-1) through two ranges of the length-tension curve: 1.11 to 1.01 L0 and 1.01 to 0.91 L0. Both heat rate and mechanical power were higher at short length than at long length. Th...

journal_title：Journal of muscle research and cell motility

authors： Gilbert SH

更新日期：1986-04-01 00:00:00

abstract：:Two single mutations, R694N and E45Q, were introduced in the beta isoform of human cardiac myosin to remove permanent salt bridges E45:R694 and E98:R694 in the SH1-SH2 helix of the myosin head. Beta isoform-specific bridges E45:R694 and E98:R694 were discovered in the molecular dynamics simulations of the alpha and be...

journal_title：Journal of muscle research and cell motility

authors： Gargey A,Iragavarapu SB,Grdzelishvili AV,Nesmelov YE

更新日期：2020-09-14 00:00:00

abstract：:Changes in the isoform patterns of myosin heavy chains (MHC) and Ca2+-ATPase (SERCA) were studied in long-term (72 days) denervated slow-twitch soleus muscles of euthyroid and hyperthyroid rabbits. MHC isoforms were separated electrophoretically. SERCA isoforms were assessed by electrophoretic separation of the trypsi...

journal_title：Journal of muscle research and cell motility

authors： Hämäläinen N,Pette D

更新日期：2001-01-01 00:00:00

abstract：:High speed isovelocity shortening using a servo-controlled lever was performed on isolated whole frog sartorius muscles at long lengths to ensure substantial passive tension. The tension records of unstimulated control experiments were subtracted from the tension records of fully-tetanized experiments on the same musc...

journal_title：Journal of muscle research and cell motility

authors： Seo JS,Krause PC,McMahon TA

更新日期：1994-02-01 00:00:00

abstract：:The remodelling of connective tissue components is a fundamental requirement for a number of pivotal processes in cell biology. These may include myoblast migration and fusion during development and regeneration. In other systems, similar biological processes are facilitated by secretion of the matrix metalloproteinas...

journal_title：Journal of muscle research and cell motility

authors： Lewis MP,Tippett HL,Sinanan AC,Morgan MJ,Hunt NP

更新日期：2000-04-01 00:00:00

abstract：:The pattern of expression of different types of myosin heavy chains and the development of different generations of muscle cells during foetal life were studied in four bovine muscles with widely varying characteristics, the Masseter, Longissimus thoracis, Cutaneus trunci and Diaphragma. Different complementary techni...

journal_title：Journal of muscle research and cell motility

authors： Picard B,Robelin J,Pons F,Geay Y

更新日期：1994-08-01 00:00:00

abstract：:Several mutations in the beta-myosin heavy chain gene cause hypertrophic cardiomyopathy. This study investigates (1) the in vitro velocities of translocation of fluorescently-labelled actin by beta-myosin purified from soleus muscle of 30 hypertrophic cardiomyopathy patients with seven distinct beta-myosin heavy chain...

journal_title：Journal of muscle research and cell motility

authors： Cuda G,Fananapazir L,Epstein ND,Sellers JR

更新日期：1997-06-01 00:00:00

abstract：:The effect of urocortin (Uro), a recently discovered neuropeptide with selectivity towards corticotropin-releasing hormone type 2 receptor, was tested on whole cell currents expressed by guinea-pig gastric antrum smooth muscle cells. Uro (1 pmol/l-1 nmol/l) caused a concentration-dependent increase of Ca2+-sensitive K...

journal_title：Journal of muscle research and cell motility

authors： Petkova-Kirova PS,Gagov HS,Duridanova DB

更新日期：2000-01-01 00:00:00

abstract：:The sonic muscle of the oyster toadfish, Opsanus tau, can produce unfused contractions at 300 Hz. Electron microscopy shows a great abundance of the Sarcoplasmic reticulum (SR) in this muscle, but no functional characterization of the capabilities of the SR has been reported. We measured the oxalate-supported Ca2+ upt...

journal_title：Journal of muscle research and cell motility

authors： Feher JJ,Waybright TD,Fine ML

更新日期：1998-08-01 00:00:00

abstract：:Appropriate organization of cytoskeletal components are required for normal distribution and intracellular localization of different ion channels and proteins involved in calcium homeostasis, signal transduction, and contractile function of striated muscle. Proteins of the contractile system are in direct or indirect ...

journal_title：Journal of muscle research and cell motility

authors： Gönczi M,Dienes B,Dobrosi N,Fodor J,Balogh N,Oláh T,Csernoch L

更新日期：2020-01-18 00:00:00

abstract：:Guinea-pig soleus muscles were denervated and electrically stimulated for periods of 43 to 66 days. Stimuli were in 1 s bursts of 40 Hz pulses, repeated every 5 min. Other guinea-pigs were denervated for 82 days without stimulation and, in a third group, the soleus muscle was necrotized and allowed to regenerate witho...

journal_title：Journal of muscle research and cell motility

authors： Lewis DM,al-Amood WS,Schmalbruch H

更新日期：1997-10-01 00:00:00

abstract：:Isolated frog muscle fibres of four different lengths (L0, initial; L1, 15%; L2, 25%; and L3, 35% stretched vs. L0) were stimulated continuously (3 min) by suprathreshold rectangular pulses at three different frequencies (f1 = 5 Hz, f2 = 6.7 Hz and f3 = 10 Hz). Using a pair of electrodes mounted at a fixed distance, t...

journal_title：Journal of muscle research and cell motility

authors： Radicheva N,Mileva K,Vydevska M

更新日期：1998-01-01 00:00:00

abstract：:Quantitative (muscle fibre number and cross-sectional areas) and qualitative (myosin isoforms and metabolic enzyme activities) characteristics of two muscles, M. pectoralis major and M. anterior latissimus dorsi, were compared among male chickens of two lines during growth from hatching to adulthood. The lines were de...

journal_title：Journal of muscle research and cell motility

authors： Remignon H,Gardahaut MF,Marche G,Ricard FH

更新日期：1995-04-01 00:00:00

abstract：:Troponin T (TnT) is one of the muscle regulatory proteins and is thought to be related to unique contractile properties in diverse muscles and also to myogenesis. The expression of TnT isoforms in the chicken wing muscles was investigated by two-dimensional gel electrophoresis and immunoblotting with an antiserum agai...

journal_title：Journal of muscle research and cell motility

authors： Miyazaki JI,Akutsu S,Satow N,Hirao C,Yao Y

更新日期：2001-01-01 00:00:00

abstract：:Several factors have an influence on the improvement of muscle activity and motor co-ordination of mammals during post-natal development. One of them is voltage sensitive L-type calcium channel function. In striated muscles of adult mammals these channels are located in T-tubule membranes thus linking the on-coming ac...

journal_title：Journal of muscle research and cell motility

authors： Mänttäri S,Pyörnilä A,Harjula R,Järvilehto M

更新日期：2001-01-01 00:00:00

abstract：:The organization of the principal cytoskeletal components (actin, tubulin and 10 nm filament protein) have been compared by immunofluorescence microscopy in two populations of chick heart fibroblasts, previously shown to be adapted respectively for rapid, directed migration or adhesion and growth. We find that neither...

journal_title：Journal of muscle research and cell motility

authors： Badley RA,Couchman JR,Rees DA

更新日期：1980-03-01 00:00:00