Abstract：
:A detailed phylogenetic analysis for mammalian members of the family Herpesviridae, based on molecular sequences is reported. Sets of encoded amino acid sequences were collected for eight well conserved genes that are common to mammalian herpesviruses. Phylogenetic trees were inferred from alignments of these sequence sets using both maximum parsimony and distance methods, and evaluated by bootstrap analysis. In all cases the three recognised subfamilies (Alpha-, Beta- and Gammaherpesvirinae), and major sublineages in each subfamily, were clearly distinguished, but within sublineages some finer details of branching were incompletely resolved. Multiple-gene sets were assembled to give a broadly based tree. The root position of the tree was estimated by assuming a constant molecular clock and also by analysis of one herpesviral gene set (that encoding uracil-DNA glycosylase) using cellular homologues as outgroups. Both procedures placed the root between the Alphaherpesvirinae and the other two subfamilies. Substitution rates were calculated for the combined gene sets based on a previous estimate for alphaherpesviral UL27 genes, where the time base had been obtained according to the hypothesis of cospeciation of virus and host lineages. Assuming a constant molecular clock, it was then estimated that the three subfamilies arose approximately 180 to 220 million years ago, that major sublineages within subfamilies were probably generated before the mammalian radiation of 80 to 60 million years ago, and that speciations within sublineages took place in the last 80 million years, probably with a major component of cospeciation with host lineages.
journal_name
J Mol Bioljournal_title
Journal of molecular biologyauthors
McGeoch DJ,Cook S,Dolan A,Jamieson FE,Telford EAdoi
10.1006/jmbi.1995.0152subject
Has Abstractpub_date
1995-03-31 00:00:00pages
443-58issue
3eissn
0022-2836issn
1089-8638pii
S0022-2836(85)70152-0journal_volume
247pub_type
杂志文章abstract：:The calcium-binding basement membrane protein fibulin-1C was shown to bind nidogen in a calcium-dependent fashion. Fibulin-1C consists of small N (domain 1) and C-terminal (domain III) globular structures connected by a central rod (domain II) composed of nine epidermal growth factor (EG) modules, eight of which posse...
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journal_title：Journal of molecular biology
pub_type： 杂志文章
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1016/0022-2836(94)90040-x
更新日期：1994-11-04 00:00:00
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1016/j.jmb.2003.07.011
更新日期：2003-10-03 00:00:00
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pub_type： 杂志文章
doi：10.1006/jmbi.1998.2124
更新日期：1998-11-06 00:00:00
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1006/jmbi.1994.0169
更新日期：1995-04-07 00:00:00
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1006/jmbi.1994.1060
更新日期：1994-01-21 00:00:00
abstract：:The periplasmic ribose and glucose-galactose receptors (binding proteins) of Gram-negative bacteria compete for a common inner membrane receptor in bacterial chemotaxis, as well as being the essential primary receptors for their respective membrane transport systems. The high-resolution structures of the periplasmic r...
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pub_type： 杂志文章
doi：10.1016/0022-2836(92)90898-t
更新日期：1992-09-20 00:00:00
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1006/jmbi.1994.1025
更新日期：1994-01-14 00:00:00
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journal_title：Journal of molecular biology
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doi：10.1006/jmbi.1996.0407
更新日期：1996-07-19 00:00:00
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journal_title：Journal of molecular biology
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更新日期：1994-09-09 00:00:00
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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更新日期：2000-02-25 00:00:00
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journal_title：Journal of molecular biology
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doi：10.1006/jmbi.1994.1430
更新日期：1994-07-08 00:00:00
abstract：:We have solved the crystal structure of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis (Mtb) at 1.95 A resolution. AcpS, a 4-phosphopantetheinyl transferase, activates two distinct acyl carrier proteins (ACPs) that are present in fatty acid synthase (FAS) systems FAS-I and FAS-II, the ACP-I d...
journal_title：Journal of molecular biology
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