A simple method for estimating the skeletal uptake of diphosphonates.

Abstract:

:It is possible to obtain an estimate of the bone uptake of diphosphonates after 3 h (BU) on the basis of the difference between the dose administered and the sum of the component eliminated in the urine plus the component present in the extra-osseous volume of distribution. The results of this simple method have been compared in 15 patients using whole body retention at 24 h (determined by means of a complete urine collection) and the ratio of plasma concentrations of 51Cr-EDTA/99Tcm-HMDP after 3 h (DPS). Both DPS and BU can be used on a practical basis, and therefore be used routinely with scintigraphy. The added advantage is that, for BU, the use of a second radiopharmaceutical is avoided.

journal_name

Nucl Med Commun

authors

Galli G,Bagnato A,Galli M

doi

10.1097/00006231-199509000-00008

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

773-8

issue

9

eissn

0143-3636

issn

1473-5628

journal_volume

16

pub_type

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