Abstract:
:Impaired cardiac fatty acid uptake, assessed by the radiolabelled fatty acid analogue beta-methyl-p-iodophenyl pentadecanoic acid (I-123-BMIPP), is observed in the myocardium following acute ischaemic events, but the long-term prognostic implication has not been established. This study aimed to determine the prognostic value of cardiac BMIPP uptake in patients with acute myocardial infarction. Following the assessment of thallium-201 and I-123-BMIPP uptake, 101 post-infarct patients were prospectively followed up with primary end points of cardiac death, heart failure and non-fatal infarction. During a mean follow-up of 28 months, three cardiac deaths, three non-fatal infarctions, 23 revascularizations and four recurrences of angina pectoris were observed. Multivariate analysis identified reduced uptake of BMIPP and perfusion, no beta-blocking treatment and greater thallium-BMIPP mismatch (i.e. larger BMIPP defect than thallium defect) as significant predictors for overall cardiac events. Prior myocardial infarction, reduced left ventricular ejection fraction and greater thallium-BMIPP mismatch were selected as independent predictors of harder cardiac events. Female patients, those with greater BMIPP defect or greater thallium-BMIPP mismatch showed worse clinical outcomes. The inclusion of BMIPP data improved the prognostic values of conventional significant predictors. In conclusion, impaired myocardial I-123-BMIPP uptake and perfusion-BMIPP mismatch are related to a high probability of fatal and non-fatal cardiac events, suggesting the aetiological relevance and prognostic value of impaired cardiac fatty acid metabolism in viable, but jeopardized, myocardium following acute myocardial infarction.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Nakata T,Kobayashi T,Tamaki N,Kobayashi H,Wakabayashi T,Shimoshige S,Oh-Hori K,Hamabe K,Hirasawa K,Matsuki T,Shogase T,Furudate M,Shimamoto Kdoi
10.1097/00006231-200010000-00003keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
897-906issue
10eissn
0143-3636issn
1473-5628journal_volume
21pub_type
杂志文章,多中心研究abstract:BACKGROUND:Interobserver agreement in measuring positron emission tomography (PET)/computed tomography (CT) parameters is critical for head and neck cancer management. The purpose of this study is to assess the interobserver agreement when measuring the standardized uptake value (SUV) parameters and the diameter of pri...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834e5397
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Paragangliomas are rare tumours of neural crest origin that express high levels of somatostatin receptor. Ga-68 DOTATATE PET/CT is a widely accepted method for imaging of neuroendocrine tumours. This study was performed to review a Ga-68 DOTATATE PET/CT patient database and to establish the impact of the moda...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001130
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:The present study evaluated the usefulness of postoperative fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) in the management of olfactory neuroblastoma (ONB). MATERIALS AND METHODS:Ten patients (eight men and two women; mean age, 48.5 years) with histologically confirmed ONB who underwent ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000135
更新日期:2014-08-01 00:00:00
abstract::In an effort to develop new, clinically useful 99Tcm-diaminodithiol (99Tcm-DADT) complexes for the evaluation of regional cerebral perfusion, basic diaminodithiols (DADT-TM, DADT-HM and DADT-MHM) and three diaminodithiol ligands functionalized with p-iodophenethyl (DADT-IPE), N-ethyl-p-fluorophenethyl amine (DADT-EFPE...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199112000-00007
更新日期:1991-12-01 00:00:00
abstract::The level of Na(+)-K+ adenosine triphosphatase (ATPase) has been demonstrated to be correlated with tumour growth potential, and accelerated active transport of K+ carried out by Na(+)-K+ ATPase is said to be a trigger of 201Tl affinity for malignant tumour cells. Therefore, 201Tl scintigraphy appears to be a good ind...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199403000-00002
更新日期:1994-03-01 00:00:00
abstract::Mammography is the screening test of choice for breast cancer. Its low specificity leads to a large number of unnecessary biopsies. Scintimammography, with either Tc-sestamibi (MIBI) or Tc-anti-carcinoembryonic antigen (CEA) Fab', has been proposed as a non-invasive test to lower the high false positive rate of mammog...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200303000-00009
更新日期:2003-03-01 00:00:00
abstract:PURPOSE:Exclusive use of the half-time of clearance of a filtration marker in the bolus injection, single compartment technique for measuring glomerular filtration rate (GFR) is a convenient approach that gives GFR (GFR(SO)) already scaled for extracellular fluid volume (ECV). It has been criticized as less accurate th...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3281ec51b5
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Two ligands viz. tert-butyl dithiocarbamate (TBDTC) and methoxyisobutyl dithiocarbamate (MIBDTC), which are analogous to the tert-butyl isonitrile (TBI) and sestamibi (MIBI) ligands, were synthesized and labelled with the [99mTcN] core to evaluate their potential as myocardial agents. As these complexes have ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000183793.51474.2f
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:We investigated the localization pattern of a novel imaging agent, (99m)Tc-labelled glucosamine (ECDG), in a variety of rheumatic conditions. MATERIALS AND METHODS:Sixteen patients were recruited into the study, with either active rheumatoid arthritis or osteoarthritis. (99m)Tc-ECDG was prepared in-house an...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000096
更新日期:2014-06-01 00:00:00
abstract::We studied two different methods for the evaluation of differential renal function in a group of 100 patients with various kidney disorders whose effective renal plasma flow (ERPF) had been calculated previously by single 125I-orthoiodohippurate (OIH) injection and multiple blood sampling. Patients were divided into t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198910000-00008
更新日期:1989-10-01 00:00:00
abstract::In ten patients with malignant gliomas the regional cerebral metabolic rate for glucose (rCMRGlc) was studied with positron emission tomography (PET) using 2-18F-deoxyglucose (18FDG) before and within 1 to 7 days after intra-arterial chemotherapy with the nitrosourea derivative ACNU (iaACNU). Three patients were studi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198911000-00002
更新日期:1989-11-01 00:00:00
abstract::Radiolabeled sucralfate has been utilized by several investigators to evaluate peptic ulcer, active inflammatory bowel disease, esophageal ulcer, and gastric cancer. A review of the available literature indicates that radiolabeled sucralfate has been used to evaluate peptic ulcer and active inflammatory bowel diseases...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the capability of F-FDG PET/computed tomography (CT)-related metabolic parameters to predict lymph node metastasis (LNM) and occult lymph node metastasis (OLNM) in patients with esophageal squamous cell carcinoma (ESCC). METHODS:Totally 84 patients undergoing curative...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001050
更新日期:2019-09-01 00:00:00
abstract::Marked changes in cardiac function have been noted in patients with hyperthyroidism or hypothyroidism due both to changes in sympathetic system function and to biochemical modifications of myocardial tissue. Metaiodobenzylguanidine (MIBG), an analogue of norepinephrine, can be used to evaluate myocardial sympathetic t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199908000-00006
更新日期:1999-08-01 00:00:00
abstract::Comparisons of gastric emptying between different centres are difficult because of wide variations in methods. Reproducibility of a method is very important before it is used to compare different subjects or to assess the effect of treatment. The aim of this study was to measure the reproducibility of gastric emptying...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199801000-00011
更新日期:1998-01-01 00:00:00
abstract::In 70 patients with angiographically confirmed coronary heart disease and in 10 controls, a 4 h exercise (E) (injection of 150 MBq 99Tcm-MIBI) rest (R) (800 MBq) protocol was employed. Of these, 10 patients with 21 myocardial defects after E received a third injection 24 h after. SPECT was used to image myocardial dis...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199002000-00002
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVES:(68)Ga-Dotatoc has become the PET radiopharmaceutical of choice for the diagnosis and treatment follow-up of neuroendocrine tumours. (68)Ga-Dotatoc is prepared on-site through a so-called magisterial preparation. The use of an appropriate buffer during the radiolabelling step is essential to maximize the lab...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32833acb99
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To prepare the rhenium-188 (188Re)-arginine-glycine-aspartic acid (RGD) peptide in a convenient manner and to evaluate its potential as an agent for alphavbeta3 integrin receptor-positive tumors. METHODS:Radiolabeled RGD was obtained by conjugating the His group at the end of peptide with fac-[188Re(H2O)3(CO...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283334e48
更新日期:2010-02-01 00:00:00
abstract::We studied 20 patients aged 46-69 years (mean 57 years) undergoing long-term haemodialysis (HD) and 20 age- and sex-matched controls with single photon emission tomography (SPET) and 99Tcm-hexamethyl-propyleneamine-oxime to look for regional abnormalities in cerebral blood flow (CBF) and their relation to cognitive dy...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199607000-00011
更新日期:1996-07-01 00:00:00
abstract::Equilibrium radionuclide angiography (ERNA) is the 'gold standard' for assessing left ventricular ejection fraction (LVEF). The aim of the study was to determine whether the left ventricular cavity-to-myocardium count ratio (LVCMR) from 201Tl myocardial single photon emission computed tomography (SPECT) correlated wit...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200103000-00004
更新日期:2001-03-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834fc5e6
更新日期:2012-03-01 00:00:00
abstract::The purpose of this study was to validate different scintigraphic approaches for assessing acute myocardial infarctions. 201Tl, 99Tcm pyrophosphate (PPi) and combined 201Tl/99Tcm PPi tomograms were evaluated in 115 consecutive patients, in 85 of whom clinical examination revealed acute myocardial infarction. The overa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199009000-00005
更新日期:1990-09-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001242
更新日期:2020-06-23 00:00:00
abstract:INTRODUCTION:The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction. We report here on the rhesus monk...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283060c72
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:The liver is the most frequent metastatic site from colorectal cancer and about 20% of these patients are treated by surgical resection. However, the 5-year disease-free survival (DFS) following resection is only about 25% and 5-year overall survival (OS) about 38%. The aim of the study was to evaluate the ab...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001235
更新日期:2020-09-01 00:00:00
abstract::Dual-isotope studies using 123I and 201Tl allow the assessment of sympathetic reinnervation in patients following heart transplantation. 123I-meta-iodobenzyl guanidine (123I-MIBG) serves as a tracer of the integrity of the sympathetic nervous system. 201Tl is used for landmarking to allow better delineation of the myo...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199508000-00009
更新日期:1995-08-01 00:00:00
abstract::We evaluated the clinical usefulness of 99Tcm-N,N-ethylenedicysteine (99Tcm-EC), a new renal tubular agent, in normal children and in children with various renal disorders and compared it with 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In a first group of children (Group 1), which included 15 patients and 4 normal c...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199701000-00009
更新日期:1997-01-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000282
更新日期:2015-05-01 00:00:00
abstract::The study of the kinetics of labelled platelets makes sense only when the platelets preserve their viability after separation and labelling. The separation and labelling procedures described in the manual of two producers of 111In-oxinate (Amersham, Mallinckrodt) have been evaluated by in vitro aggregation tests. The ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::The suggestion by the National Institute for Clinical Excellence (NICE) to more than triple the number of myocardial perfusion scintigraphy (MPS) procedures carried out by the NHS each year is a challenge both in terms of numbers of gamma cameras available to carry out the scans and qualified staff to supervise stress...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,实务指引
doi:10.1097/MNM.0b013e32818a6e72
更新日期:2007-07-01 00:00:00