Abstract：
:Productive infection of the central nervous system by HIV predominantly involves the white matter and basal ganglia. Involvement of the cerebral cortex with neuronal loss is also described in AIDS patients but not in asymptomatic HIV-positive patients. The mechanism of neuronal damage is unknown. To enquire whether neuronal loss in AIDS may be due to an apoptotic process, we examined the cerebral cortex from 12 patients who died from AIDS using two different methods: in situ end labelling and gel electrophoresis of DNA to demonstrate DNA fragmentation. None of the patients had cerebral opportunistic infection or tumour. Four patients had no significant neuropathological changes, eight patients had variable cerebral atrophy and four of them also had productive HIV infection of the brain. These patients were compared with four HIV-positive asymptomatic patients, five seronegative asymptomatic controls, and two seronegative patients with Alzheimer's disease. We demonstrated neuronal apoptosis in the cortex in all AIDS patients, as well as in the Alzheimer's patients. Apoptosis was not observed in the asymptomatic cases whether seropositive or seronegative. Neuronal apoptosis was more severe in atrophic brains, and did not directly correlate with productive HIV infection, suggesting an indirect mechanism of neuronal damage is most likely.
journal_name
Neuropathol Appl Neurobioljournal_title
Neuropathology and applied neurobiologyauthors
Adle-Biassette H,Levy Y,Colombel M,Poron F,Natchev S,Keohane C,Gray Fdoi
10.1111/j.1365-2990.1995.tb01053.xsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
218-27issue
3eissn
0305-1846issn
1365-2990journal_volume
21pub_type
杂志文章abstract：:Dysfunction of the ubiquitin-dependent proteolytic pathway contributes to progressive accumulation of ubiquitinated protein inclusions in neurodegenerative disorders, such as Parkinson's disease (PD). Ubiquitin C-terminal hydrolase-L1 (UCH-L1), alternatively designated protein gene product 9.5 (PGP9.5), is a neural de...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.2001.00313.x
更新日期：2001-04-01 00:00:00
abstract：AIMS:Apolipoprotein A-I (apoA-I), the principal apolipoprotein associated with high-density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid. Previous studies have reported either no impact or vascular-specific effects of apoA-I knockout (KO) on β-amyloid (Aβ) pathology. Ho...
journal_title：Neuropathology and applied neurobiology
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journal_title：Neuropathology and applied neurobiology
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1990.tb00945.x
更新日期：1990-04-01 00:00:00
abstract：:Inflammatory cells from the meninges of guinea-pigs with acute EAE have been isolated and quantitated. A mean of 7.5 x 10(6) cells were recovered from the brains of animals showing clinical signs of disease in contrast to only 1.5 x 10(6) cells in the controls. The immunological specificity of the meningeal inflammato...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1981.tb00082.x
更新日期：1981-03-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
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doi：10.1111/nan.12518
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12167
更新日期：2015-06-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12479
更新日期：2018-12-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
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更新日期：2010-04-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.2002.t01-1-00410.x
更新日期：2002-12-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2007.00799.x
更新日期：2007-06-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2010.01107.x
更新日期：2010-12-01 00:00:00
abstract：:Unless treated with effective antiretroviral therapy many AIDS patients develop a characteristic vacuolar myelopathy of the spinal cord associated with moderate clinical disability. Opinion is divided as to whether vacuolar myelopathy is causally linked to HIV myelitis. To investigate this further, spinal cord patholo...
journal_title：Neuropathology and applied neurobiology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2990.1999.00152.x
更新日期：1999-02-01 00:00:00
abstract：:Diabetic neuropathy is probably the most common and one of the most disabling complications of diabetes mellitus. Although several possible pathogenetic mechanisms for this complication have been suggested, they cannot easily be tested in man. Therefore animal models with induced or spontaneous onset of diabetes melli...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1985.tb00023.x
更新日期：1985-07-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1992.tb00795.x
更新日期：1992-08-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
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更新日期：1985-11-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
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更新日期：1991-02-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1983.tb00332.x
更新日期：1983-03-01 00:00:00
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更新日期：2009-04-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12161
更新日期：2015-02-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1994.tb01012.x
更新日期：1994-12-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1982.tb00315.x
更新日期：1982-11-01 00:00:00
abstract：AIMS:Neurogenesis in adult humans occurs in at least two areas of the brain, the subventricular zone of the telencephalon and the subgranular layer of the dentate gyrus in the hippocampal formation. We studied dentate gyrus subgranular layer neurogenesis in patients subjected to tailored antero-mesial temporal resectio...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.1985.tb00007.x
更新日期：1985-03-01 00:00:00
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journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1990.tb01159.x
更新日期：1990-06-01 00:00:00
abstract：AIMS:Microglial cells have been originally identified as a target for the CXC chemokine, SDF-1, by their expression of CXCR4. More recently, it has been recognized that SDF-1 additionally binds to CXCR7, which depending on the cell type acts as either a nonclassical, a classical or a scavenger chemokine receptor. Here,...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12015
更新日期：2013-10-01 00:00:00
