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Synthesis and antineoplastic activity of phenyl-substituted benzenesulfonylhydrazones of 2-pyridinecarboxyaldehyde 1-oxide.

Abstract：

:A variety of derivatives of 2-pyridinecarboxaldehyde 1-oxide benzenesulfonylhydrazone, containing substituents on the benzene or pyridine rings as well as on the nitrogen atom which is bonded directly to the sulfonyl group, have been synthesized. The antineoplastic activity of these compounds has been assessed in mice bearing either leukemia L1210 or P388. The most potent agents in this series were 2,4-dimethoxy,3,4-dimethoxy-, and 2,4,6-trimethylbenzenesulfonylhydrazone of 2-pyridinecarboxyaldehyde 1-oxide, all causing disappearance of tumors in 20-80% of leukemia-bearing mice.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Loh W,Cosby LA,Sartorelli AC

doi

10.1021/jm00180a010

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

631-4

issue

6

eissn

0022-2623

issn

1520-4804

journal_volume

23

pub_type

杂志文章

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