Effects of delta-aminolaevulinic acid on contractile activity of rabbit duodenum.

abstract：:Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase), and tynorphin has been synthesized as a more potent inhibitor of dipeptidyl aminopeptidase III. In this s...

journal_title：European journal of pharmacology

authors： Yamazaki T,Honda M,Yamamoto Y,Hazato T,Ono H

更新日期：2001-02-16 00:00:00

abstract：:We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the superficial gray layer of the superior colliculus of rats. These studies showed dense binding of (3-[125I]iodotyrosyl13)-[Ala11,15]Ac-endothelin-1-(6-2 1) (BQ3020) (for endothelin ETB receptors), while tissues incubated with [125I...

journal_title：European journal of pharmacology

authors： D'Amico M,Di Filippo C,Rossi F

更新日期：1998-04-17 00:00:00

abstract：:Cardiac remodeling after myocardial infarction is in part triggered and maintained by reactive oxygen species. Antioxidants such as probucol have shown positive short-term effects on these cardiac interstitial changes in different experimental models after intraperitoneal administration or after per-oral administratio...

journal_title：European journal of pharmacology

authors： Betge S,Lutz K,Roskos M,Figulla HR

更新日期：2007-03-08 00:00:00

abstract：:Most virus infections induce cycloxygenase-2 (COX-2) expression and subsequent prostaglandin E(2) (PGE(2)) production in cells, an inflammatory response that might be detrimental to virus replication and pathogenesis. This response in dengue virus infection remains to be elucidated. Triptolide and tetrandrine, compoun...

journal_title：European journal of pharmacology

authors： Liou JT,Chen ZY,Ho LJ,Yang SP,Chang DM,Liang CC,Lai JH

更新日期：2008-07-28 00:00:00

abstract：:The specific, irreversible binding of [3H]beta-funaltrexamine (beta-FNA) to mu opioid receptors in slices from the corpus striatum and midbrain region containing the ventral tegmentum area (VTA) was accomplished by incubation with [3H]beta-FNA followed by a washing procedure with 1 microM unlabeled naltrexone in the w...

journal_title：European journal of pharmacology

authors： Takahashi M,Portoghese PS,Takemori AE

更新日期：1988-05-10 00:00:00

abstract：:[3H]Prostaglandin E2 (PGE2) binding sites were 10-fold enriched from a porcine fundic mucosal homogenate by differential centrifugation and subsequent discontinuous sucrose gradient separation. PGE2 bound with an activation energy of 66 kJ/mol to a single class of sites with an affinity of 1.5 +/- 0.4 nM and a capacit...

journal_title：European journal of pharmacology

authors： Beinborn M,Netz S,Staar U,Sewing KF

更新日期：1988-03-01 00:00:00

abstract：:In animals given citalopram (10 mg/kg) twice daily for 14 days a further dose of 1 mg/kg, administered 24 h after the last dose, markedly increased cortical dialysate serotonin (5-hydroxytryptamine, 5-HT), but had no effect in control animals. The effect on dialysate 5-HT in the dorsal raphe was not increased by the c...

journal_title：European journal of pharmacology

authors： Invernizzi R,Bramante M,Samanin R

更新日期：1994-08-01 00:00:00

abstract：:Inhibition of glutamate carboxypeptidase (GCP) II (EC 3.4.17.21), also termed N-acetylated alpha-linked acidic dipeptidase (NAALADase), has been shown to protect against ischemic injury presumably via decreasing glutamate and increasing N-acetyl-aspartyl-glutamate (NAAG). NAAG is a potent and selective mGlu3 receptor ...

journal_title：European journal of pharmacology

authors： Thomas AG,Liu W,Olkowski JL,Tang Z,Lin Q,Lu XC,Slusher BS

更新日期：2001-10-26 00:00:00

abstract：:The pharmacological profile of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a novel non-peptide angiotensin AT1 receptor antagonist, was studied in vitro and in vivo. YM358 competed with [125I][Sar1, Ile8]angiotensin II for angiotensi...

journal_title：European journal of pharmacology

authors： Shibasaki M,Fujimori A,Takanashi M,Kusayama T,Tokioka T,Satoh Y,Okazaki T,Uchida W,Inagaki O,Yanagisawa I

更新日期：1997-09-24 00:00:00

abstract：:Oxidative stress is associated with exacerbation of renal injuries in hypertension. In clinical studies benidipine hydrochloride (benidipine), a dihydropyridine calcium channel blocker with antioxidant activity, reduced oxidative stress. However, the mechanism of suppression of oxidative stress remains to be fully cha...

journal_title：European journal of pharmacology

authors： Matsubara M,Akizuki O,Ikeda J,Saeki K,Yao K,Sasaki K

更新日期：2008-02-02 00:00:00

abstract：:In two separate research centres the ability of RO 15-4513 to protect rats against the lethal effects of ethanol (7.5 and 15 g/kg) was investigated. In neither study did RO 15-4513 offer protection against ethanol-induced lethality or the loss of righting reflex caused by these doses of ethanol. These data fail to rep...

journal_title：European journal of pharmacology

authors： Nutt DJ,Lister RG,Rusche D,Bonetti EP,Reese RE,Rufener R

更新日期：1988-06-22 00:00:00

abstract：:The effect of intracutaneous adrenaline and noradrenaline (5 X 10(-12) and 5 X 10(-11) mol) was examined on the oedema (Evans blue dye leakage) response of rats to several inflammatory agents. The catecholamines reduced the oedema response to all agents tested except prostaglandin E1 (PGE1) which was significantly pot...

journal_title：European journal of pharmacology

authors： O'Duffy G,Chahl LA

更新日期：1979-08-15 00:00:00

abstract：:Nitric oxide can exert either protective or damaging effects on the gastric mucosa. To further explore the role of nitric oxide in the modulation of gastric mucosal defense, the effects of intra-arterial administration of the precursor, L-arginine, on susceptibility of the gastric mucosa to damage induced by topically...

journal_title：European journal of pharmacology

authors： Ferraz JG,Tigley A,Wallace JL

更新日期：1994-07-21 00:00:00

abstract：:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

journal_title：European journal of pharmacology

authors： Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

更新日期：1988-07-14 00:00:00

abstract：:The 5-lipoxygenase inhibitors WY-50,295 tromethamine, A-64,077, L-663,536 and ICI-207,968 were compared in a reverse passive Arthus reaction-induced pleurisy model of eicosanoid biosynthesis in the rat. When a 1 h pretreatment schedule was employed, all four inhibitors equivalently blocked leukotriene B4 (LTB4) produc...

journal_title：European journal of pharmacology

authors： Berkenkopf JW,Weichman BM

更新日期：1991-01-25 00:00:00

abstract：:G(s)α is a ubiquitously expressed G protein α-subunit that couples receptors to the generation of intracellular cyclic AMP. The G(s)α gene GNAS is a complex gene that undergoes genomic imprinting, an epigenetic phenomenon that leads to differential expression from the two parental alleles. G(s)α is imprinted in a tiss...

journal_title：European journal of pharmacology

authors： Chen M,Nemechek NM,Mema E,Wang J,Weinstein LS

更新日期：2011-06-11 00:00:00

abstract：:The aim of this study was to determine the effects of 4-(4-bromophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (TP4-a new S-triazole derivative possessing anticonvulsant properties in preclinical studies) on the protective action of four different classical antiepileptic drugs (carbamazepine, phenob...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Plech T,Wujec M

更新日期：2012-09-05 00:00:00

abstract：:The influence of the delta-opioid receptor antagonist naltrindole upon sensitization to the locomotor activating effects of cocaine was assessed. Activity in response to a challenge dose of cocaine (20 mg/kg, i.p.) was significantly increased in rats which had received cocaine (20 mg/kg, i.p.) once daily for 3 days as...

journal_title：European journal of pharmacology

authors： Heidbreder C,Goldberg SR,Shippenberg TS

更新日期：1993-10-19 00:00:00

abstract：:Histamine induced a dose-dependent stimulation of 3H-catecholamine(CA) efflux (superfusion procedure) from hypothalamic, striatal, hippocampal and cortical slices. The extra-hypothalamic regions were the most sensitive to histamine. Efflux of 14C-GABA and 14C-(acetyl)choline was not affected. The effect of histamine o...

journal_title：European journal of pharmacology

authors： Subramanian N,Mulder AH

更新日期：1977-05-15 00:00:00

abstract：:The aim of this experiment was to clarify whether an amino acid supplement could enhance the therapeutic effect of vitamin B2 (riboflavin 5'-sodium phosphate; purity > 97%) in mice with lipopolysaccharide-induced shock. Six hours after injection of a lethal dose of lipopolysaccharide, treatment (6-h i.v. infusion) was...

journal_title：European journal of pharmacology

authors： Toyosawa T,Suzuki M,Kodama K,Araki S

更新日期：2004-06-16 00:00:00

abstract：:This study investigated sex-related differences in rat papillary muscle force generation in response to altered extracellular [Ca2+] ([Ca2+](o), 0.2 to 5.0 mM) and to L-type Ca2+ channel modulators (nifedipine and Bay K8644). At all [Ca2+]o examined, contractile force was significantly greater in male than female papi...

journal_title：European journal of pharmacology

authors： Curl CL,Delbridge LM,Wendt IR

更新日期：2008-05-31 00:00:00

abstract：:Induction of lower lip retraction after local infusion of the selective 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal and median raphe nuclei was measured. Infusion of 8-OH-DPAT (2.5, 5 and 10 micrograms/rat) into the median raphe nucleus caused an immediate and dose-de...

journal_title：European journal of pharmacology

authors： Berendsen HH,Bourgondien FG,Broekkamp CL

更新日期：1994-10-03 00:00:00

abstract：:This report describes the molecular pharmacological properties of LR-B/081 (methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[2'-(1H-tetrazol-5- yl) [1,1'-biphenyl]-4-yl]methyl]-1 (6H)-pyrimidinyl]methyl]- 3-thiophenecarboxilate), a novel non-peptide angiotensin II receptor antagonist. This compound potently displaced [3H]angiote...

journal_title：European journal of pharmacology

authors： Renzetti AR,Criscuoli M,Salimbeni A,Subissi A

更新日期：1995-07-18 00:00:00

abstract：:Topoisomerase I (Top1) is the specific target of the anticancer drug camptothecin (CPT) that interferes with enzyme activity promoting Top1-mediated DNA breaks and inhibition of DNA and RNA synthesis. To define the specific transcriptional response to CPT, we have determined the CPT-altered transcription profiles in y...

journal_title：European journal of pharmacology

authors： Lotito L,Russo A,Bueno S,Chillemi G,Fogli MV,Capranico G

更新日期：2009-01-28 00:00:00

abstract：:The activity of angiotensin-converting enzyme in rat choroid plexus was higher than that of any other organ, being 6--7 times higher than that in lung and more than 50 times higher than in any other region of brain. Rabbit choroid plexus also had high activity of enzyme while that of human choroid plexus was relativel...

journal_title：European journal of pharmacology

authors： Arregui A,Iversen LL

更新日期：1978-11-01 00:00:00

abstract：:Pentoxifylline, a methylxanthine derivative, has been widely used to improve erythrocyte deformability and capillary blood circulation in patients with claudication and cerebrovascular disorders as well as in animals with sepsis. Here, we investigate the effects of pentoxifylline on the hypotension, vascular hyporeact...

journal_title：European journal of pharmacology

authors： Wu CC,Liao MH,Chen SJ,Yen MH

更新日期：1999-05-28 00:00:00

abstract：:We have monitored the binding of [125I]thienylphencyclidine ([125I]TCP), a novel high affinity radioiodinated ligand that specifically recognizes the NMDA (N-methyl-D-aspartate) receptor in rat brain membranes. [125I]TCP binds with an affinity of about 30 nM, and recognizes a similar number of binding sites to previou...

journal_title：European journal of pharmacology

authors： Reynolds IJ,Rothermund K,Rajdev S,Fauq AH,Kozikowski AP

更新日期：1992-05-12 00:00:00

abstract：:Cumulative dose-response curves of Ca2+-induced tension increments were studied in K+-depolarized helical strips of dog coronary arteries. Adenosine 10(-4) M reduced the Ca2+ sensitivity of the strips without altering the maximal tension with full Ca2+ activation. In contrast, acidosis of pH 7.05 significantly diminis...

journal_title：European journal of pharmacology

authors： Turnheim K,Pittner H,Kolassa N,Kraupp O

更新日期：1977-01-21 00:00:00

abstract：:Receptor activation of G-proteins can be measured by agonist-stimulated [35S]GTP gamma S binding in the presence of excess guanosine diphosphate (GDP). To determine whether opioid and cannabinoid receptor-mediated G-protein activation correlate with their receptor densities, this study compared opioid- and cannabinoid...

journal_title：European journal of pharmacology

authors： Sim LJ,Selley DE,Xiao R,Childers SR

更新日期：1996-06-20 00:00:00

abstract：:The aim of this study was to investigate the effects of peritonitis on spontaneous contractions of ileum and jejunum smooth muscles isolated from rats. Peritonitis was induced by cecal ligation and puncture in 8 rats. Another group of 8 rats underwent a sham operation and acted as controls. Twenty-four hours after the...

journal_title：European journal of pharmacology

authors： Koyluoglu G,Bagcivan I,Karadas B,Guney C,Durmus N,Altun A,Kaya T

更新日期：2008-02-02 00:00:00