Abstract:
:The hexamer (m5 dC-dG)3 has been synthesized and its three-dimensional structure determined by a single crystal X-ray diffraction analysis. The structure has been refined to a final R value of 15.6% at 1.3 A resolution. The molecule forms a left-handed Z-DNA helix which is similar to the unmethylated Z-DNA structure. The presence of the methyl group has resulted in slight changes in the twist angle between successive base pairs and modification of some of the interatomic contacts. Methylation of cytosine in the C5 position is associated with a relative destabilization of the B-DNA structure and a stabilization through hydrophobic bonding of the Z-DNA structure.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Fujii S,Wang AH,van der Marel G,van Boom JH,Rich Adoi
10.1093/nar/10.23.7879subject
Has Abstractpub_date
1982-12-11 00:00:00pages
7879-92issue
23eissn
0305-1048issn
1362-4962journal_volume
10pub_type
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