Abstract:
:A blind volunteer was inoculated in one eye with an isolate of Chlamydia trachomatis in 1961 and followed for 20 years. During this time, many observations were made of his clinical responses to the first inoculation and several subsequent inoculations with the same and other strains, chlamydial shedding, and antibody and cell-mediated immune responses. Evidence is presented that partial resistance to chlamydial eye infection developed during repeated infections and that antibodies, cell-mediated immune reactions, and specific antigen in conjunctival cells persisted for many years after the last infection. The antibody response was directed mainly against the original infecting immunotype, regardless of whether the response was restimulated by infection with the same immunotype or with other immunotypes. The lymphocyte stimulation response appeared to be species specific.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Hanna L,Jawetz E,Dawson CR,Thygeson Pdoi
10.1128/JCM.16.5.895-900.1982subject
Has Abstractpub_date
1982-11-01 00:00:00pages
895-900issue
5eissn
0095-1137issn
1098-660Xjournal_volume
16pub_type
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