Abstract:
:An atypical toxin variant of Clostridium botulinum (strain 657) was isolated from the feces of a 6-week-old female infant whose symptoms and clinical history were consistent with infant botulism. Toxin detected in the feces and the toxin produced by isolates from the feces and from two rectal swabs could be neutralized by type B botulinal antitoxin only at very high ratios of of antitoxin to toxin in the neutralization mixture. One international unit of type B antitoxin neutralized only about 10 lethal doses of 657 toxin as compared with approximately 10,000 lethal doses of conventional type B toxin from the Beans strain. Antitoxin prepared against 657 toxin was 10 times more effective against the conventional toxin than against the homologous toxin. Toxoid-antitoxin-binding studies indicate that both 657 toxin and type B toxin are heterogeneous and that both toxins may contain the same molecular variants, but that the proportions of the variants are different in each.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Hatheway CL,McCroskey LM,Lombard GL,Dowell VR Jrdoi
10.1128/JCM.14.6.607-611.1981subject
Has Abstractpub_date
1981-12-01 00:00:00pages
607-11issue
6eissn
0095-1137issn
1098-660Xjournal_volume
14pub_type
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