Detection of favorable oral cephalosporin-clavulanate interactions by in vitro disk approximation susceptibility testing of extended-spectrum-Beta-lactamase-producing members of the enterobacteriaceae.

Abstract:

:Extended-spectrum-beta-lactamase (ESBL)-producing members of the Enterobacteriaceae are often resistant to multiple drug classes, making therapy of urinary infections with oral antibiotics difficult. Previously it was shown that amoxicillin-clavulanate can provide clavulanate inhibition of ESBLs and protect an oral cephalosporin present in combination when tested by broth microdilution. This study has shown that disk approximation testing could detect favorable cephalosporin-clavulanate interactions among a group of 101 previously characterized members of the Enterobacteriaceae with CTX-M, SHV, or TEM ESBLs.

journal_name

J Clin Microbiol

authors

Campbell JD,Lewis JS 2nd,McElmeel ML,Fulcher LC,Jorgensen JH

doi

10.1128/JCM.06248-11

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

1023-6

issue

3

eissn

0095-1137

issn

1098-660X

pii

JCM.06248-11

journal_volume

50

pub_type

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