Abstract:
:We have investigated the origin of rapidly adhering (RA) cells in three cases of neural tube defects (two anencephali, one encephalocele). We were able to demonstrate the presence of glial fibrillary acidic (GFA) protein in variable percentages (4--80%) of RA cells cultured for 4--6 days by use of indirect immunofluorescence with GFA antiserum. Cells cultured from amniotic fluids of normal pregnancies and fetal fibroblasts were completely GFA protein negative. GFA protein is well established as a highly specific marker for astrocytes. Demonstration of astrocytes may prove to be a criterion of high diagnostic value for neural tube defects. The percentage of astrocytes decreased with increasing culture time, while the percentage of fibronectin positive cells increased both in amniotic fluid cell cultures from neural tube defects and normal pregnancies.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Cremer M,Schachner M,Cremer T,Schmidt W,Voigtländer Tdoi
10.1007/BF00274694subject
Has Abstractpub_date
1981-01-01 00:00:00pages
365-70issue
3eissn
0340-6717issn
1432-1203journal_volume
56pub_type
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