Abstract:
:The karyotype of leukemic cells was studied in 88 acute nonlymphocytic leukemia (ANLL) patients. Chromosome abnormalities were discovered in 78.4% of all patients and in 72.5% of the 69 patients studied before treatment. Characteristic abnormalities: translocations 8;21, 15;17, 9;22 or 6;9, rearrangements of 11q, gain of chromosomes 8 or 21, and loss or deletion of chromosomes 5 or 7 were detected in 56 of 69 patients with abnormal karyotypes. Translocation 8;21 was revealed in 27 patients; 20 of them had M2 FAB-form, four had M1, and three had M4. In patients with t(8;21) the incidence of complete remission was higher and the duration of first remission and survival longer than in patients with other abnormalities or with a normal karyotype.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Prigogina EL,Fleischman EW,Puchkova GP,Mayakova SA,Volkova MA,Protasova AK,Frenkel MAdoi
10.1007/BF00291604subject
Has Abstractpub_date
1986-06-01 00:00:00pages
137-46issue
2eissn
0340-6717issn
1432-1203journal_volume
73pub_type
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