Abstract:
:We have used the polymerase chain reaction (PCR) technique for the diagnosis of hydatidiform mole, a trophoblastic disease. For this, we targeted the hypervariable 3' flanking region of the APOB gene (APOB/VNTR) because of its high heterozygosity index (0.61) in the Japanese population. We examined seven clinical cases which were tentatively diagnosed as hydatidiform moles. Five of these revealed DNA segments unique to the paternal APOB allele, allowing us to diagnose a complete mole. The PCR technique for targeting the APOB/VNTR appears useful for early diagnosis of hydatidiform mole.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Fukuyama R,Takata M,Kudoh J,Sakai K,Tamura S,Shimizu Ndoi
10.1007/BF00204186subject
Has Abstractpub_date
1991-06-01 00:00:00pages
216-8issue
2eissn
0340-6717issn
1432-1203journal_volume
87pub_type
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