Abstract:
:A 300 base pair deletion near the 3'-end of the gene encoding Type II (cartilage) collagen has been implicated in the pathogenesis of perinatal lethal osteogenesis imperfecta. We have found similar deletions occurring at a high frequency in normal Asian Indian and West Indian populations generated by a length polymorphism just beyond the 3'-end of the gene. We suggest that this polymorphism provides an alternative explanation of the original results.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Sykes BC,Ogilvie DJ,Wordsworth BPdoi
10.1007/BF00389455subject
Has Abstractpub_date
1985-01-01 00:00:00pages
35-7issue
1eissn
0340-6717issn
1432-1203journal_volume
70pub_type
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