Abstract:
:We have isolated an X chromosome probe, St35.691 (DXS305), which detects two RFLPs with TaqI and PstI, whose combined heterozygosity is about 60%. This probe has been assigned to Xq28 by physical and genetic mapping and is very closely linked to DXS52, DXS15, and the coagulation factor VIII gene (F8C). The best estimate of the recombination fraction for the DXS52-DXS305 interval is 0.014, with a lod score of 50.1. Multipoint analysis places DXS305 on the same side of F8C as DXS52, but complete ordering of the three loci was not possible with our present data. This highly informative marker should be useful in the precise mapping of the many disease genes that have been assigned to the Xq28 band.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Vincent A,Kretz C,Oberlé I,Mandel JLdoi
10.1007/BF00288280subject
Has Abstractpub_date
1989-04-01 00:00:00pages
85-6issue
1eissn
0340-6717issn
1432-1203journal_volume
82pub_type
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