A new polymorphic marker very closely linked to DXS52 in the q28 region of the human X chromosome.

Abstract:

:We have isolated an X chromosome probe, St35.691 (DXS305), which detects two RFLPs with TaqI and PstI, whose combined heterozygosity is about 60%. This probe has been assigned to Xq28 by physical and genetic mapping and is very closely linked to DXS52, DXS15, and the coagulation factor VIII gene (F8C). The best estimate of the recombination fraction for the DXS52-DXS305 interval is 0.014, with a lod score of 50.1. Multipoint analysis places DXS305 on the same side of F8C as DXS52, but complete ordering of the three loci was not possible with our present data. This highly informative marker should be useful in the precise mapping of the many disease genes that have been assigned to the Xq28 band.

journal_name

Hum Genet

journal_title

Human genetics

authors

Vincent A,Kretz C,Oberlé I,Mandel JL

doi

10.1007/BF00288280

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

85-6

issue

1

eissn

0340-6717

issn

1432-1203

journal_volume

82

pub_type

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