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48- to 96-hour preservation of canine kidneys by initial perfusion and hypothermic storage using the Euro-Collins solution.

Abstract：

:In 1976 a standardised hypertonic 'intracellular' perfusate (Euro-Collins solution) was recommended for renal preservation in all donor centres collaborating with the Eurotransplant Organisation. In order to investigate the effectiveness of this perfusate canine kidneys were initially flushed with Euro-Collins solution and subjected to 48, 72 and 96 h of cold storage and autotransplantated. Immediate contralateral nephrectomy was performed after autotransplantation. The serum creatinine served as a parameter of postoperative renal function. Under laboratory conditions successful preservation was achieved after minimal (less than 5 min) warm ischaemia for up to 96 h of cold ischaemia and after 15 min of warm ischaemia for up to 48 h of cold ischaemia. Our results suggest that initial flushing and hypothermic storage of kidneys using Euro-Collins solution is a satisfactory preservation method when human cadaver kidneys can be harvested under adequate conditions.

journal_name

Eur Urol

journal_title

European urology

authors

Dreikorn K,Horsch R,Röhl L

doi

10.1159/000473336

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

221-4

issue

4

eissn

0302-2838

issn

1873-7560

journal_volume

6

pub_type

杂志文章

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