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1,2-Dihydropyrido[3,4-b]pyrazines: structure-activity relationships.

Abstract：

:Certain derivatives containing the 1,2-dihydropyrido[3,4-b]pyrazine (1-deaza-7,8-dihydropteridine) ring system are active against experimental neoplasms in mice. The mechanism of action of these agents has been attributed to the accumulation of cells at mitosis. Identification of the structural features that are necessary for activity was accomplished by evaluation of modified 1-deazapteridines and ring and ring-opened analogues. Relative to ethyl 4-amino-1-deaza-7,8-dihydro-6-[(N-methylanilino)methyl]pteridine-2-carbamate (11) and the corresponding 6-phenyl compound (12), no antitumor activity was observed with 7,8-dihydropteridines, 3-deaza-7,8-dihydropteridines, and the corresponding heteroaromatic compounds. Also, activity was diminished or destroyed when 1-deaza-7,8-dihydropteridines were oxidized to 1-deazapteridines or reduced to 1-deaza-5,6,7,8-tetrahydropteridines. In addition, replacement of the 4-amino group with other substituents destroyed activity. The presence of a 6-substituent containing an aryl group appeared to be necessary for activity, which was increased when a methyl group was substituted at the 7-position.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Temple C Jr,Wheeler GP,Elliott RD,Rose JD,Comber RN,Montgomery JA

doi

10.1021/jm00355a018

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

91-5

issue

1

eissn

0022-2623

issn

1520-4804

journal_volume

26

pub_type

杂志文章

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