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Synthesis and antitumor activity of cis-dichloroplatinum (II)-N-aminated nucleoside complexes.

Abstract：

:N-Aminated nucleoside complexes of cis-dichloroplatinum(II) were synthesized, and their antitumor activities against L1210 cells in mice and in vitro were studied. While the native nucleosides failed to show any antitumor activity, the complexes exhibited high antitumor activity and had no nephrotoxicity in mice. Studies on their mode of action in vitro indicated that the ligands played characteristic roles in the appearance of antitumor activity; ribonucleoside complexes caused the inhibition of RNA synthesis, and deoxyribo- or arabinonucleoside complexes caused the inhibition of DNA synthesis.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Maeda M,Abiko N,Uchida H,Sasaki T

doi

10.1021/jm00370a006

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

444-9

issue

4

eissn

0022-2623

issn

1520-4804

journal_volume

27

pub_type

杂志文章

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