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8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells.

Abstract：

:A variety of 8-substituted guanosine and 2'-deoxyguanosine derivatives were synthesized and tested as inducers of the differentiation of Friend murine erythroleukemia cells in culture. The most active agents in the guanosine series were 8-substituted-N(CH3)2, -NHCH3, -NH2, -OH, and -SO2CH3, which caused 68, 42, 34, 33, and 30% of erythroleukemia cells to attain benzidine positivity, a functional measure of maturation, at concentrations of 5, 1, 0.4, 5, and 5 mM, respectively. The 8-OH derivative of the 2'-deoxyguanosine series produced comparable activity, causing 62% benzidine-positive cells at a level of 0.2 mM. These findings indicate that 8-substituted analogues of guanosine and 2'-deoxyguanosine have the potential to terminate leukemia cell proliferation through conversion to end-stage differentiated cells.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Lin TS,Cheng JC,Ishiguro K,Sartorelli AC

doi

10.1021/jm00147a012

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

1194-8

issue

9

eissn

0022-2623

issn

1520-4804

journal_volume

28

pub_type

杂志文章

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