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Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.

Abstract：

:Using a combination of iterative structure-based design and an analysis of oral pharmacokinetics and antiviral activity, AG1343 (Viracept, nelfinavir mesylate), a nonpeptidic inhibitor of HIV-1 protease, was identified. AG1343 is a potent enzyme inhibitor (Ki = 2 nM) and antiviral agent (HIV-1 ED50 = 14 nM). An X-ray cocrystal structure of the enzyme-AG1343 complex reveals how the novel thiophenyl ether and phenol-amide substituents of the inhibitor interact with the S1 and S2 subsites of HIV-1 protease, respectively. In vivo studies indicate that AG1343 is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. AG1343 (Viracept) has recently been approved for marketing for the treatment of AIDS.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Kaldor SW,Kalish VJ,Davies JF 2nd,Shetty BV,Fritz JE,Appelt K,Burgess JA,Campanale KM,Chirgadze NY,Clawson DK,Dressman BA,Hatch SD,Khalil DA,Kosa MB,Lubbehusen PP,Muesing MA,Patick AK,Reich SH,Su KS,Tatlock JH

doi

10.1021/jm9704098

subject

Has Abstract

pub_date

1997-11-21 00:00:00

pages

3979-85

issue

24

eissn

0022-2623

issn

1520-4804

pii

jm9704098

journal_volume

40

pub_type

杂志文章

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