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The synthesis of nucleoside 5'-O-(1,1-dithiotriphosphates).

Abstract：

:Appropriately protected nucleoside 5'-O-(2-thio-1,3,2-dithiaphospholanes) react with inorganic pyrophosphate in the presence of a strong base catalyst (DBU) to give nucleoside 5'-O-(1,1-dithiotriphosphates) 1a-g. The latter compounds, including an AZT analogue, show modest antivirial activity against HIV-1 and HIV-2 replication in CEM cells. The AZT and deoxyadenosine derivatives were found to be inhibitors of HIV reverse transcriptase.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Okruszek A,Olesiak M,Balzarini J

doi

10.1021/jm00048a021

subject

Has Abstract

pub_date

1994-10-28 00:00:00

pages

3850-4

issue

22

eissn

0022-2623

issn

1520-4804

journal_volume

37

pub_type

杂志文章

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