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A novel series of 2,5-substituted tryptamine derivatives as vascular 5HT1B/1D receptor antagonists.

Abstract：

:The design, synthesis, and activity of a novel series of 2,5-substituted tryptamine derivatives at vascular 5HT1B-like receptors is described. Several important auxiliary binding sites of the 5HT1B-like receptor have been proposed following various modifications to the 2-substituent and especially to the methylene- or ethylene-linked 5-side chain. Careful design of new molecules based on a proposed pharmacophoric model of the 5HT1B-like receptor has resulted in the discovery of ethyl 3-[2-(dimethylamino)ethyl]-5-[2-(2, 5-dioxo-1-imidazolidinyl)ethyl]-1H-indole-2-carboxylate (40), a highly potent, silent, competitive, and selective antagonist which shows affinity at the vascular 5HT1B-like receptors only. Changes to the size of the 2-ester substituent have a significant effect on affinity at the 5HT1B-like receptor and other receptors. Prudent placement of the carbonyl substituent in the heterocycle of the 5-side chain is crucial for good affinity and selectivity over the 5HT2A and other receptors. Several key structural and electronic features were identified which are crucial for producing antagonism within a tryptamine-based series. An electron deficient indole ring system appears essential in order to achieve antagonism, and this is achieved by the inclusion of electron-withdrawing groups at the 2-position of the indole ring. The molecule displacement within the receptor resulting from the inclusion of the bulky 2-substituents also enhances antagonism as this results in the removal of the pi electron density of the indole ring from the region of the receptor normally occupied by the indole ring of 5HT. There also appears to be a structural requirement on the side chain incorporating the protonatable nitrogen, and this is achieved by the inclusion of the bulky 2-ester group which neighbors the 3-ethylamine side chain.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Moloney GP,Robertson AD,Martin GR,MacLennan S,Mathews N,Dodsworth S,Sang PY,Knight C,Glen R

doi

10.1021/jm9605849

subject

Has Abstract

pub_date

1997-07-18 00:00:00

pages

2347-62

issue

eissn

0022-2623

issn

1520-4804

pii

jm9605849

journal_volume

pub_type

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A novel series of 2,5-substituted tryptamine derivatives as vascular 5HT1B/1D receptor antagonists.