Artifactual hypercalcemia in multiple myeloma.

Abstract:

:A calcium-binding IgG K monoclonal protein in a patient with multiple myeloma and asymptomatic hypercalcemia was recognized, isolated, and characterized. In addition to binding by the whole IgG molecules, calcium was bound by purified Fab fragments and recombined heavy and light chains. In a competitive binding study, the isolated myeloma protein did not bind magnesium. Recognition of calcium-binding myeloma proteins is important in order to avoid therapy for hypercalcemia.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Annesley TM,Burritt MF,Kyle RA

subject

Has Abstract

pub_date

1982-09-01 00:00:00

pages

572-5

issue

9

eissn

0025-6196

issn

1942-5546

journal_volume

57

pub_type

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