Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay.

Abstract:

:The effects in the chicken embryo assay of four Alternaria metabolites (alternariol [AOH], alternariol methyl ether [AME], altenuene [ALT], and tenuazonic acid [TA]) were investigated. Administered to 7-day-old chicken embryos by yolk sac injection, AOH, AME, and ALT caused no mortality or teratogenic effect at doses up to 1,000, 500, and 1,000 micrograms per egg, respectively. TA exhibited a calculated 50% lethal dose of 548 micrograms per egg, with no teratogenic effect observed at either lethal or sublethal doses.

journal_name

Appl Environ Microbiol

authors

Griffin GF,Chu FS

doi

10.1128/AEM.46.6.1420-1422.1983

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

1420-2

issue

6

eissn

0099-2240

issn

1098-5336

journal_volume

46

pub_type

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